Biomimetic approaches in bone tissue engineering: Integrating biological and physicomechanical strategies

Fernández‐Yagüe, Marc A.; Abbah, Sunny Akogwu; McNamara, Laoise M.; Zeugolis, Dimitrios I.; Pandit, Abhay; Biggs, Manus

doi:10.1016/j.addr.2014.09.005

Cited by 435 publications

(349 citation statements)

References 425 publications

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“…As already mentioned, sHAs and especially nano-structured HAs are excellent drug carriers, and may not only be used to carry osteogenic or angiogenic growth factors, but also drugs, e.g. with antibacterial effects [11,14,82,[117][118][119][120]. For discussion on antibiotic release from CaP materials see also the article of Prados-Frutos et al in this issue.…”

Section: Discussionmentioning

confidence: 99%

“…The use of MSCs or induced pluripotent stem cells seeded on suitable scaffolds appears to be a potential approach in bone defect therapies. The proliferation and differentiation of these cells into an osteoblastic phenotype has been shown [120,125]. When bone substitutes will be seeded with cells, different problems like seeding efficiency, density or predifferentiation of the cells have to overcome.…”

Section: Discussionmentioning

confidence: 99%

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Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Götz¹,

Papageorgiou²

2017

CPB

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Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad range of bone substitutes, synthetic hydroxyapatite has drawn much attention, as they are considered to be biocompatible, non-immunogenic, osteoconductive and osteoinductive. Scope of this review is to summarize existing knowledge concerning the molecular, cellular and pharmaceutical aspects of synthetic bone substitutes for oral and maxillofacial grafting.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Götz¹,

Papageorgiou²

2017

CPB

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“…These soluble molecules are able to regulate signaling cascades that specifically influence cellular responses such as differentiation and proliferation [28].…”

Section: Biological Factors In Bone Regenerationmentioning

confidence: 99%

“…Most common growth factors related to bone healing, osteoinduction and osteoconduction are: PDGF, BMPs [15,28,29], IGFs [28,30], TGF-β [15,28], FGF [24,29] and VEGF [15,24,29].…”

Section: Physiological Process Of Bone Regenerationmentioning

confidence: 99%

Regenerative Medicine: A New Paradigm in Bone Regeneration

Chaparro¹,

Linero²

2016

Advanced Techniques in Bone Regeneration

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Bone defects are the cause of functional disability and the restoration of skeletal function remains an important challenge on orthopedics, neurosurgery and oral and maxillofacial surgery. Because of the limitations of the currently used techniques for the reconstruction of bone defects and the difficulties for the implementation of new therapeutic strategies, a new paradigm in the field of reconstructive surgery has arisen, leading to tissue engineering and regenerative medicine. Mesenchymal stem cells (MSC) have emerged as a promising alternative for the treatment of bone lesions. It was postulated that the therapeutic action was the result of proliferation and differentiation of MSCs, replacing injured tissue. However, recent studies have shown that MSCs secrete a number of trophic factors that have a strong effect during repair and tissue regeneration. This represents a shift from a paradigm centered on MSC proliferation and differentiation to a new paradigm in which the MSCs exert their beneficial effect by the secretion of paracrine factors that induce endogenous repair mechanisms. This chapter will bring together basic and clinical aspects, focused on novel findings on MSC paracrine effect and the development of new therapeutic strategies based on growth factors, cytokines and signaling molecules involved in bone regeneration.

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“…47,48 In this study, we investigated the biocompatibility of Cu-CSG coatings using BMSCs, which is an important cell source in bone tissue engineering. Cell proliferation tests revealed that all Cu-doped coatings were favorable for the cell proliferation except Cu IV group ( Figure 10B).…”

mentioning

confidence: 99%

Evaluation of antibacterial, angiogenic, and osteogenic activities of green synthesized gap-bridging copper-doped nanocomposite coatings

Huang

Cai

et al. 2017

IJN

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Titanium (Ti) and its alloys have been widely used in clinics for years. However, their bio-inert surface challenges application in patients with compromised surgical conditions. Numerous studies were conducted to modify the surface topography and chemical composition of Ti substrates, for the purpose of obtaining antibacterial, angiogenic, and osteogenic activities. In this study, using green electrophoretic deposition method, we fabricated gap-bridging chitosan-gelatin (CSG) nanocomposite coatings incorporated with different amounts of copper (Cu; 0.01, 0.1, 1, and 10 mM for Cu I, II, III, and IV groups, respectively) on the Ti substrates. Physicochemical characterization of these coatings confirmed that Cu ions were successfully deposited into the coatings in a metallic status. After rehydration, the coatings swelled by 850% in weight. Mechanical tests verified the excellent tensile bond strength between Ti substrates and deposited coatings. All Cu-containing CSG coatings showed antibacterial property against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus . The antibacterial property was positively correlated with the Cu concentration. In vitro cytocompatibility evaluation demonstrated that activities of bone marrow stromal cells were not impaired on Cu-doped coatings except for the Cu IV group. Moreover, enhanced angiogenic and osteogenic activities were observed on Cu II and Cu III groups. Overall, our results suggested that Cu-doped CSG nanocomposite coating is a promising candidate to functionalize Ti materials with antibacterial, angiogenic, and osteogenic properties.

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Biomimetic approaches in bone tissue engineering: Integrating biological and physicomechanical strategies

Cited by 435 publications

References 425 publications

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Regenerative Medicine: A New Paradigm in Bone Regeneration

Evaluation of antibacterial, angiogenic, and osteogenic activities of green synthesized gap-bridging copper-doped nanocomposite coatings

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