Biomimetic dense lamellar scaffold based on a colloidal complex of the polyaniline (PANi) and biopolymers for electroactive and physiomechanical stimulation of the myocardial

Alves, Thaís Francine Ribeiro; Souza, Juliana Ferreira de; Amaral, Venâncio Alves; Almeida, Danilo Araujo; Grotto, Denise; Lima, Renata de; Aranha, Norberto; Filho, Lindemberg da Mota Silveira; Júnior, José M. Oliveira; Barros, Cecília Torqueti de; Severino, Patrícia; Souza, Alexandro; Chaud, Marco V.

doi:10.1016/j.colsurfa.2019.123650

Cited by 19 publications

(29 citation statements)

References 29 publications

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“…NOISHIKI et al [35] studied films composed of FB and cellulose fibers and the results showed improved mechanical resistance. In our study, we observed the same material behaviour when FB was added to BC as the authors above [19,24,32,34,35], which means the mechanical properties were improved.…”

Section: Resultssupporting

confidence: 80%

“…The main spectra associated with BC are 3346 cm -1 (stretch O-H); 2888 cm -1 (C-H stretch), 1653 cm -1 (OH-deformation) and 1044 cm -1 (CO-deformation) [19,[24][25][26][27]. However, a peak correspondent the βglucoside linkages between the glucose units at ∼890 cm −1 and C O symmetric bridge stretching of primary alcohol (1040 cm −1 ) and C O C antisymmetric bridge stretching ( cm −1 ).…”

Section: Resultsmentioning

confidence: 99%

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Bacterial nanocellulose and fibroin: natural products to produce a structure membranes

et al. 2021

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Fibroin (FB) and bacterial nanocellulose (BC) are natural products, being used in biomedicine, electronics, food industries and other areas. Both show biocompatibility, able to be used for many different purposes. The blending of fibroin and bacterial nanocellulose was design to produce a biocompatible material to be applied with a medical device. For this reason, the objective of this work was to evaluate the structure properties of the blending of BC and FB. Thus, FB was extracted from Bombyx mori and BC was produced by fermentation process utilizing Gluconacetobacter xylinus. The membranes composed of BC-FB were produced by immersion contact for 24 hours, at 25°C, in 100rpm; without crosslinking agent. After the production the membrane samples were dried and characterized by Fourier transform infrared spectroscopy (FTIR spectroscopy), mechanical proprieties, swelling efficiency, scanning electron microscopy (SEM) and computerized microtomography (µCt). Results indicate that the hydrogen-bonded porous membranes obtained displayed anisiotropic, closed and interconnected porous morphology. The morphometric characteristics, which resemble a honeycomb and consist of a long structure with high connectivity and high total porosity, amplify the areas of BC-FB blend applications, with potential utilization with optoelectronic devices, in areas ranging from environmental to tissue engineering. Furthermore, the production by immersion contact will allow the upscale process and the development of green label material.

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Section: Resultssupporting

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Bacterial nanocellulose and fibroin: natural products to produce a structure membranes

et al. 2021

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“…Gelatin–PANi fiber mats have been analyzed in vitro in regard to H9c2 and C2C12 myoblast cell behavior, indicating enhanced cell migration, proliferation, and/or differentiation (myotube formation) . Recently, the combination of collagen, fibroin, HA, and PANi has been used to generate hydrogel scaffolds, which supported the proliferation of H9C2 cells . While a few reports examined the effect of PANi in fibrous scaffolds, to the best of our knowledge, a combination of collagen, HA, and PANi has so far not been investigated regarding electrospun fiber mats for an application in cardiac tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Nanofibrous Composite with Tailorable Electrical and Mechanical Properties for Cardiac Tissue Engineering

Roshanbinfar

Vogt

Ruther

et al. 2019

Adv Funct Materials

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Cardiac tissue engineering is a promising strategy to prevent functional deterioration or even to enhance cardiac function upon myocardial infarction. Here, electrospun fiber mats containing different combinations of electrically conductive polyaniline, collagen, and/or hyaluronic acid are assessed regarding material properties and compatibility with cardiomyocyte attachment and function. Microstructure analysis reveals that collagen fiber mats contain a wide range of fiber diameters after crosslinking (from ≈300 nm to ≈5 µm); all other fiber mats contain fibers in the range of ≈120 to ≈300 nm. Fiber mats exhibit comparable electrical conductivity to and greater mechanical properties than the native human myocardium, which is considered beneficial. Cell–matrix interaction analysis utilizing postnatal rat cardiomyocytes reveals that the fiber mats are non‐cytotoxic and permit cell attachment and contraction. Fiber mats containing collagen (9.89%), hyaluronic acid (1.1%), and polyaniline (PANi, 1.34%) exhibit the most favorable properties with longer contraction time, higher contractile amplitude, and lower beating rates. Improved contraction is accompanied by increased connexin 43 expression. Importantly, this fiber mat is a suitable material for human‐induced pluripotent stem cell–derived cardiomyocytes regarding cytotoxicity, cell attachment, and function. Collectively, these data demonstrate that fiber mats made of collagen, hyaluronic acid, and polyaniline are promising materials for cardiac tissue engineering.

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“…If this process is associated with freeze‐drying, a dense lamellar scaffold is produced. Scaffolds fabricated from plastic compression and freeze‐drying may have potential in terms of their architecture, as they may have porosity and ideal interconnectivity to mimic the cardiac extracellular matrix 11,12 …”

Section: Introductionmentioning

confidence: 99%

Effects of a collagen hyaluronic acid silk‐fibroin patch with the electroconductive element polyaniline on left ventricular remodeling in an infarct heart model

et al. 2022

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Biodegradable cardiac patches have been able to induce improvement in left ventricular (LV) remodeling. A novel scaffold patch made with collagen and silk-fibroin (COL-SF) was further associated to polyaniline (PANi) to increase conductivity. Thus, this study investigated the safety of the association of PANi to a patch, and the improvement in LV remodeling in a myocardial infarct (MI) rat model. Wistar rats underwent MI induction. MI was confirmed with echocardiographic and after 2 weeks, animals (n = 10/group) were randomized into: (a) COL-SF hyaluronic acid patch, (b) PANi hyaluronic acid patch, (c) MI Control (just repeat thoracotomy). Healthy animals were also followed. Echocardiography was performed at pre-treatment, and at 2-, 4-, and 8-weeks post-treatment. Hearts underwent hemodynamic evaluation on Langendorff apparatus and histology for LV thickness and percent of infarct size. Liver, kidneys, and blood samples were evaluated for biochemical, hematological, oxidative stress, and histology. There was a tendency of lower %infarct size in patched animals. LV thickness was higher in the patched animals than controls.Functional echocardiographic indices %Fractional shortening and %LV ejection fraction decreased in the MI control group, but not in the patched animals. PANi presented higher %LVEF versus MI control. PANi presented higher liver transaminases; no morphological changes were observed in histology. Elevation of antioxidant markers was observed. COL-SF and PANi patches were able to induce better remodeling features compared to MI controls on %infarct size and LV thickness and have not presented echocardiographic worsening. Polyaniline may present a slight improvement on LV remodeling, despite associated to signs of hepatotoxicity and pro-oxidant effect.

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Biomimetic dense lamellar scaffold based on a colloidal complex of the polyaniline (PANi) and biopolymers for electroactive and physiomechanical stimulation of the myocardial

Cited by 19 publications

References 29 publications

Bacterial nanocellulose and fibroin: natural products to produce a structure membranes

Bacterial nanocellulose and fibroin: natural products to produce a structure membranes

Nanofibrous Composite with Tailorable Electrical and Mechanical Properties for Cardiac Tissue Engineering

Effects of a collagen hyaluronic acid silk‐fibroin patch with the electroconductive element polyaniline on left ventricular remodeling in an infarct heart model

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