Biomimetic Lung-Targeting Nanoparticles with Antioxidative and Nrf2 Activating Properties for Treating Ischemia/Reperfusion-Induced Acute Lung Injury

Abstract

Ischemia/reperfusion (IR)-induced acute lung injury (ALI) has a high mortality rate. Reactive oxygen species (ROS) play a crucial role in causing cellular damage and death in IR-induced ALI. In this work, we developed a biomimetic lung-targeting nanoparticle (PC@MB) as an antioxidative lung protector for treating IR-induced ALI. PC@MBs showed excellent ROS scavenging and Nrf2 activation properties, along with a lungtargeting function through autologous cell membrane coating. The PC@MBs exhibited an impressive antioxidative and pulmonary protective role via redox homeostasis recovery through Nrf2 and heme oxygenase-1 activation. PC@ MBs could maintain cell viability by effectively scavenging the intracellular ROS and restoring the redox equilibrium in the lesion. In the IR mouse model, the PC@MBs preferentially accumulated in the lung and distinctly repaired the pneumonic damage. Our strategy has the potential to offer a promising therapeutic paradigm for treating IR-induced ALI through the incorporation of different therapeutic mechanisms.

Integrative analysis of transcriptomics and metabolomics reveals the protective effect and mechanism of salidroside on testicular ischemia-reperfusion injury

“…High levels of oxygen free radicals are produced during I/R of testicular tissue, seriously damaging the sperm membrane and affecting sperm quality ( Zhong et al, 2020 ; Ning et al, 2021 ). Nrf2 is a key transcription factor for regulating ROS and is also an important regulator for maintaining intracellular redox balance ( Chen et al, 2024 ; Wang et al, 2024 ). Nrf2 can also induce and regulate the composition and expression of antioxidant proteins (including CAT, SOD, and GSH), reduce the production of ROS, and maintain the redox stability of the body ( Sang et al, 2024 ; Zhang et al, 2024 ).…”