Biomimetic nanoparticles for DC vaccination: a versatile approach to boost cancer immunotherapy

Meng, Lingyang; Teng, Zhuang; Yang, Shuang; Wang, Na; Guan, Ying-hua; Chen, Xiguang; Liu, Ya

doi:10.1039/d2nr07071e

Cited by 16 publications

(3 citation statements)

References 181 publications

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“…Over the past decade, cancer immunotherapy has emerged as an effective strategy for harnessing the patient's immune system to fight cancer [11,[105][106][107]. In recent years, the use of nanomaterials has shown considerable promise in enhancing the effectiveness of cancer immunotherapy while mitigating undesired adverse effects [76,106,[108][109][110][111][112].…”

Section: Nanoparticles In Cancer Immunotherapymentioning

confidence: 99%

The quest for nanoparticle-powered vaccines in cancer immunotherapy

Sun,

Zhao,

et al. 2024

J Nanobiotechnol

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Despite recent advancements in cancer treatment, this disease still poses a serious threat to public health. Vaccines play an important role in preventing illness by preparing the body's adaptive and innate immune responses to combat diseases. As our understanding of malignancies and their connection to the immune system improves, there has been a growing interest in priming the immune system to fight malignancies more effectively and comprehensively. One promising approach involves utilizing nanoparticle systems for antigen delivery, which has been shown to potentiate immune responses as vaccines and/or adjuvants. In this review, we comprehensively summarized the immunological mechanisms of cancer vaccines while focusing specifically on the recent applications of various types of nanoparticles in the field of cancer immunotherapy. By exploring these recent breakthroughs, we hope to identify significant challenges and obstacles in making nanoparticle-based vaccines and adjuvants feasible for clinical application. This review serves to assess recent breakthroughs in nanoparticle-based cancer vaccinations and shed light on their prospects and potential barriers. By doing so, we aim to inspire future immunotherapies for cancer that harness the potential of nanotechnology to deliver more effective and targeted treatments. Graphical abstract

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Section: Nanoparticles In Cancer Immunotherapymentioning

confidence: 99%

The quest for nanoparticle-powered vaccines in cancer immunotherapy

Sun,

Zhao,

et al. 2024

J Nanobiotechnol

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“…The other form of response by our immune system is based on the involvement of B cells in another cell signaling process by communicating with a T cell that launches the cell signaling process and communicates with an antigen presenting cell, which, in turn, can communicate with another type of T cell that can kill other cells that were infected by the virus [ 92 ]. Then, in case there is any cell infected by the virus, it will be recognized by the cytotoxic T cells that will kill that infected cell.…”

Section: Nanotechnology In Vaccinesmentioning

confidence: 99%

“…Then, in case there is any cell infected by the virus, it will be recognized by the cytotoxic T cells that will kill that infected cell. Therefore, there are a couple of different responses, but the important thing is that the B cells will either produce antibodies to fight the virus or initiate cell signaling sequences to kill infected cells ( Figure 6 ) [ 91 , 92 , 93 ].…”

Section: Nanotechnology In Vaccinesmentioning

confidence: 99%

An Overview of the Use of Nanoparticles in Vaccine Development

et al. 2023

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Vaccines represent one of the most significant advancements in public health since they prevented morbidity and mortality in millions of people every year. Conventionally, vaccine technology focused on either live attenuated or inactivated vaccines. However, the application of nanotechnology to vaccine development revolutionized the field. Nanoparticles emerged in both academia and the pharmaceutical industry as promising vectors to develop future vaccines. Regardless of the striking development of nanoparticles vaccines research and the variety of conceptually and structurally different formulations proposed, only a few of them advanced to clinical investigation and usage in the clinic so far. This review covered some of the most important developments of nanotechnology applied to vaccine technologies in the last few years, focusing on the successful race for the preparation of lipid nanoparticles employed in the successful anti-SARS-CoV-2 vaccines.

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