Biomimetic particles as therapeutics

Meyer, Randall A.; Sunshine, Joel C.; Green, Jordan J.

doi:10.1016/j.tibtech.2015.07.001

Cited by 108 publications

(61 citation statements)

References 101 publications

(106 reference statements)

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“…[164][165][166][167][168][169] This strategy is becoming a common tool in immunology, especially used in CAR-T cell clinical studies. [164][165][166][167][168][169] This strategy is becoming a common tool in immunology, especially used in CAR-T cell clinical studies.…”

Section: Engineering Dcsmentioning

confidence: 99%

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

et al. 2017

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Cancer immunotherapy, as a paradigm shift in cancer treatment, has recently received tremendous attention. The active cancer vaccination, immune checkpoint blockage (ICB) and chimeric antigen receptor (CAR) for T-cell-based adoptive cell transfer are among these developments that have achieved a significant increase in patient survival in clinical trials. Despite these advancements, emerging research at the interdisciplinary interface of cancer biology, immunology, bioengineering, and materials science is important to further enhance the therapeutic benefits and reduce side effects. Here, an overview of the latest studies on engineering biomaterials for the enhancement of anticancer immunity is given, including the perspectives of delivery of immunomodulatory therapeutics, engineering immune cells, and constructing immune-modulating scaffolds. The opportunities and challenges in this field are also discussed.

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Section: Engineering Dcsmentioning

confidence: 99%

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

et al. 2017

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“…To fabricate nanovesicles with good biodegradability and novel biological functions, scientists increasingly draw lessons from nature for inspiration[1–3]. In recent years, nanovesicles based on bio-inspired synthesis have been developed, aiming at simulating unique properties of natural organism/structures/biosynthesis pathways [4].…”

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confidence: 99%

Nanobiotechnology: Cell membrane-based delivery systems

2017

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Summary The increasingly rapid pace of research in the field of bioinspired drug delivery systems is revealing the promise of cell membrane-based nanovesicles for biomedical applications. Those cell membrane-based nanoparticles combine the natural functionalities of cell plasma membranes and the bioengineering flexibility of synthetic nanomaterials, and such versatility provides a means of designing exciting new drug formulations for personalized treatment in future nanomedicine.

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“…[ 5 ] Biomimetic particles are now considered the REVIEW next generation of particles due to their specifi c design capable to mimic features from biological systems and surfaces. [ 6,7 ] Another example of the complexity of human body can be seen when a tissue is damaged. Many natural biomolecules diffuse into the required sites to trigger the adequate cell response in an attempt to restore the tissue homeostasis.…”

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confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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Particulate systems have been widely used as containers of drugs or cells with the purpose of releasing them in a particularThe search for more effi cient therapeutic strategies and diagnosis tools is a continuous challenge. Advances in understanding the biological mechanisms behind diseases and tissues regeneration have widened the fi eld of applications of particulate systems. Particles are no more just protective systems for the encapsulated drugs, but they play an active role in the success of the therapy. Moreover, particles have been explored for innovative purposes as templates for cells growth and as diagnostic tools. Until few years ago the most relevant parameters in particles formulation were the chemistry and the size. Currently, it is known that other physical characteristics can remarkably affect the performance of particulate systems. Particles with non-conventional shapes exhibit advantages due to the increasing circulation time in blood stream, less clearance by the immune system and more effi cient cell internalization and traffi cking. Creation of compartments has been found useful to control drug release, to tune the transport of substances across biological barriers, to supply the target with more than one bioactive agent or even to act as theranostic systems. It is expected that such complex shaped and compartmentalized systems improve the therapeutic outcomes and also the patient's compliance, acting as advanced devices that serve for simultaneous diagnosis and treatment of the disease, combining agents of very different features, at the same time. In this review, we overview and analyse the most recent advances in particle shape and compartmentalization and applications of newly designed particulate systems in the biomedical fi eld.

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Biomimetic particles as therapeutics

Cited by 108 publications

References 101 publications

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

Nanobiotechnology: Cell membrane-based delivery systems

Design Advances in Particulate Systems for Biomedical Applications

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