Biomolecule−Mercury Interactions:  Modalities of DNA Base−Mercury Binding Mechanisms. Remediation Strategies

Onyido, Ikenna; Norris, and Albert R.; Buncel, Erwin

doi:10.1021/cr030443w

Cited by 414 publications

(200 citation statements)

References 191 publications

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“…In particular, the methylation of mercury enhances its lipid solubility, and methylated mercury is extremely detrimental to the central nervous system. [1][2][3][4][5][6][7] Therefore, the development of practical analytical methods for highly selective and sensitive detection of Hg 2+ and MeHg + ions in the environment, medicine, biology and food remains an urgent issue to be addressed. 8,9 Several detection techniques for Hg 2+ ions mainly rely on gas chromatography, atomic absorption spectroscopy, and cold vapour atomic fluorescence spectrometry, which are time-consuming, costly, and may not be easily accessible in most cases.…”

Section: Introductionmentioning

confidence: 99%

Highly selective detection of Hg²⁺ and MeHgI by di-pyridin-2-yl-[4-(2-pyridin-4-yl-vinyl)-phenyl]-amine and its zinc coordination polymer

Chen

et al. 2016

Inorg. Chem. Front.

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Section: Introductionmentioning

confidence: 99%

Highly selective detection of Hg²⁺ and MeHgI by di-pyridin-2-yl-[4-(2-pyridin-4-yl-vinyl)-phenyl]-amine and its zinc coordination polymer

Chen

et al. 2016

Inorg. Chem. Front.

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“…Consequently, the high toxicity of this element, and its organic derivatives, is the result of its strong interaction with thiol-containing biomolecules such as proteins and glutathione. [1,2] Although Hg II -thiolate bonds are thermodynamically very stable, their high lability and rapid ligand exchange causes the dispersion of Hg II to random thiol ligands throughout the cell causing alterations in essential biochemical processes. [1][2][3] Not surprisingly, biological systems have responded to this toxicity with different strategies that share the same basic chemical principle: the strong affinity of Hg II for thiol ligands.…”

Section: Introductionmentioning

confidence: 99%

The Application of ¹⁹⁹Hg NMR and ^199mHg Perturbed Angular Correlation (PAC) Spectroscopy to Define the Biological Chemistry of Hg^II: A Case Study with Designed Two‐ and Three‐Stranded Coiled Coils

Iranzo

Thulstrup

Ryu

et al. 2007

Chemistry A European J

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The use of de novo designed peptides is a powerful strategy to elucidate Hg(II)-protein interactions and to gain insight into the chemistry of Hg(II) in biological systems. Cysteine derivatives of the designed alpha-helical peptides of the TRI family [Ac-G-(L(a)K(b)A(c)L(d)E(e)E(f)K(g))(4)-G-NH(2)] bind Hg(II) at high pH values and at peptide/Hg(II) ratios of 3:1 with an unusual trigonal thiolate coordination mode. The resulting Hg(II) complexes are good water-soluble models for Hg(II) binding to the protein MerR. We have carried out a parallel study using (199)Hg NMR and (199m)Hg perturbed angular correlation (PAC) spectroscopy to characterize the distinct species that are generated under different pH conditions and peptide TRI L9C/Hg(II) ratios. These studies prove for the first time the formation of [Hg{(TRI L9C)(2)-(TRI L9C-H)}], a dithiolate-Hg(II) complex in the hydrophobic interior of the three-stranded coiled coil (TRI L9C)(3). (199)Hg NMR and (199m)Hg PAC data demonstrate that this dithiolate-Hg(II) complex is different from the dithiolate [Hg(TRI L9C)(2)], and that the presence of third alpha-helix, containing a protonated cysteine, breaks the symmetry of the coordination environment present in the complex [Hg(TRI L9C)(2)]. As the pH is raised, the deprotonation of this third cysteine generates the trigonal thiolate-Hg(II) complex Hg(TRI L9C)(3)(-) on a timescale that is slower than the NMR timescale (0.01-10 ms). The formation of the species [Hg{(TRI L9C)(2)(TRI L9C-H)}] is the result of a compromise between the high affinity of Hg(II) to form dithiolate complexes and the preference of the peptide to form a three-stranded coiled coil.

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“…124,125 Mercury can cause permanent brain and kidney damage with serious clinical symptoms such as deafness, visual impairment and cognitive disorders. 126 Lead can induce high blood pressure and kidney problems for adults; and it is particularly harmful to children, resulting in lower intelligence quotient, hyperactivity, slowed growth in physical or mental development, hearing problems, anemia, and kidney damage. 127 Human intake of heavy metal ions is mainly from drinking water and the contaminated food.…”

Section: Sers Sensor Design and Applicationsmentioning

confidence: 99%

Review—Surface-Enhanced Raman Scattering Sensors for Food Safety and Environmental Monitoring

Tang

Zhu

Meng

et al. 2018

J. Electrochem. Soc.

165

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This article gives a review of surface-enhanced Raman scattering (SERS) sensors for food safety and environmental pollution monitoring. It introduces the basic concepts of SERS substrates, SERS enhancement factors and mechanisms, SERS probes/labels, molecular recognition elements as well as optofluidic SERS devices (SERS sensors integrated with microfluidics). This article places an emphasis on the design strategies of various SERS sensors by utilizing fingerprinting SERS spectra or by using SERS probes. It highlights the applications of SERS sensors in detection of heavy metals (such as Hg 2+ , Pb 2+ , Cd 2+ and As 3+ ), inorganic anions (nitrite, nitrate, perchlorate and fluoride), toxic small molecules (polycyclic aromatic hydrocarbon, polychlorinated biphenyls, herbicides, pesticides, antibiotics and food additives), as well as pathogens (bacteria and viruses Food safety and environment pollution are among great challenges in the human society. There are some common pollutants in the environment and food, such as heavy metals, nitrites, phosphates, pesticides, herbicides, antibiotics, hormone, pathogens and other additives. Some pollutants initially are released into the environment, and then accumulate in the food chain, and enter human bodies. Uptake of pollutants by human poses a threat to human health to different extents. 1,2Hence it is essential to monitor pollutants in the environment and food. Currently pollutants are typically measured with various laboratorybased techniques, such as atomic absorption spectroscopy, atomic fluorescence spectrometry, X-ray fluorescence spectrum, inductively coupled plasma and ion-coupled plasma-mass spectroscopy, mass spectrometry, chromatography, capillary electrophoresis, analytical profile index (API), polymerase chain reaction (PCR), and enzymelinked immunosorbent assay (ELISA).3-7 Although these techniques have high sensitivity and accuracy, they rely on expensive instruments and require professional to treat samples and operate instruments in centralized laboratories. Additionally, analysis generally takes several hours to days. For example, 0.024 ppb of Hg 2+ and 0.023 ppb of As 3+ in drinking water can be detected using atomic absorption spectroscopy with a two-step electrothermal atomizer and hydride generation atomic fluorescence spectrometry, respectively. 8,9 However, they need multiple sample preconcentration processing and expensive instruments. PCR can improve the number of the target while ELISA can produce amplified recognition signal, which could both improve the detection sensitivity to pathogens. For example, oligonucleotide microarray with combination of CdSe/ZnS quantum dots as fluorescent labels shown high specificity and sensitivity of 10 colony forming units (CFU)/mL. 10 However, the complicated procedures are very time-consuming, and the method is also vulnerable to contamination. These laboratory-based techniques cannot meet the critical need of rapid on-site measurement of pollutants. Therefore, it is essential to develop portable sensors f...

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Biomolecule−Mercury Interactions: Modalities of DNA Base−Mercury Binding Mechanisms. Remediation Strategies

Cited by 414 publications

References 191 publications

Highly selective detection of Hg²⁺ and MeHgI by di-pyridin-2-yl-[4-(2-pyridin-4-yl-vinyl)-phenyl]-amine and its zinc coordination polymer

Highly selective detection of Hg²⁺ and MeHgI by di-pyridin-2-yl-[4-(2-pyridin-4-yl-vinyl)-phenyl]-amine and its zinc coordination polymer

The Application of ¹⁹⁹Hg NMR and ^199mHg Perturbed Angular Correlation (PAC) Spectroscopy to Define the Biological Chemistry of Hg^II: A Case Study with Designed Two‐ and Three‐Stranded Coiled Coils

Review—Surface-Enhanced Raman Scattering Sensors for Food Safety and Environmental Monitoring

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Biomolecule−Mercury Interactions: Modalities of DNA Base−Mercury Binding Mechanisms. Remediation Strategies

Cited by 414 publications

References 191 publications

Highly selective detection of Hg2+ and MeHgI by di-pyridin-2-yl-[4-(2-pyridin-4-yl-vinyl)-phenyl]-amine and its zinc coordination polymer

Highly selective detection of Hg2+ and MeHgI by di-pyridin-2-yl-[4-(2-pyridin-4-yl-vinyl)-phenyl]-amine and its zinc coordination polymer

The Application of 199Hg NMR and 199mHg Perturbed Angular Correlation (PAC) Spectroscopy to Define the Biological Chemistry of HgII: A Case Study with Designed Two‐ and Three‐Stranded Coiled Coils

Review—Surface-Enhanced Raman Scattering Sensors for Food Safety and Environmental Monitoring

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Resources

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Highly selective detection of Hg²⁺ and MeHgI by di-pyridin-2-yl-[4-(2-pyridin-4-yl-vinyl)-phenyl]-amine and its zinc coordination polymer

Highly selective detection of Hg²⁺ and MeHgI by di-pyridin-2-yl-[4-(2-pyridin-4-yl-vinyl)-phenyl]-amine and its zinc coordination polymer

The Application of ¹⁹⁹Hg NMR and ^199mHg Perturbed Angular Correlation (PAC) Spectroscopy to Define the Biological Chemistry of Hg^II: A Case Study with Designed Two‐ and Three‐Stranded Coiled Coils