Biophysics Modeling to Optimize Ion Beam Cancer Therapy

Beuve, Michaël

doi:10.1007/978-3-319-43030-0_13

Cited by 2 publications

(2 citation statements)

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“…To make use of the appearance of this highly localized energy deposit, ion beam cancer therapy (IBCT) was developed. To optimize the biological effectiveness of IBCT simulation and modelling techniques are frequently applied [74][75][76]. Details on related simulations with optimized parameter sets can be found in the work by Velten and Tomé [77].…”

Section: High-energy Particlesmentioning

confidence: 99%

Accessing radiation damage to biomolecules on the nanoscale by particle-scattering simulations

Hahn

2023

J. Phys. Commun.

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Radiation damage to DNA plays a central role in radiation therapy to cure cancer. The physico-chemical and biological processes involved encompass huge time and spatial scales. To obtain a comprehensive understanding on the nano and the macro scale is a very challenging tasks for experimental techniques alone. Therefore particle-scattering simulations are often applied to complement measurements and aide their interpretation, to help in the planning of experiments, to predict their outcome and to test damage models. In the last years, powerful multipurpose particle-scattering framework based on the Monte-Carlo simulation (MCS) method, such as Geant4 and Geant4-DNA, were extended by user friendly interfaces such as TOPAS and TOPAS-nBio. This shifts their applicability from the realm of dedicated specialists to a broader range of scientists. In the present review we aim to give an overview over MCS based approaches to understand radiation interaction on a broad scale, ranging from cancerous tissue, cells and their organelles including the nucleus, mitochondria and membranes, over radiosensitizer such as metallic nanoparticles, and water with additional radical scavenger, down to isolated biomolecules in the form of DNA, RNA, proteins and DNA-protein complexes. Hereby the degradation of biomolecules by direct damage from inelastic scattering processes during the physical stage, and the indirect damage caused by radicals during the chemical stage as well as some parts of the early biological response is covered. Due to their high abundance the action of hydroxyl radicals (•OH) and secondary low energy electrons (LEE) as well as prehydrated electrons are covered in additional detail. Applications in the prediction of DNA damage, DNA repair processes, cell survival and apoptosis, influence of radiosensitizer on the dose distribution within cells an their organelles, the study of linear-energy-transfer (LET), the relative-biological-effectiveness (RBE), ion-beam cancer-therapy, microbeam-radiation-therapy (MRT), the FLASH effect, and the radiation induced bystander effect are reviewed.

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Section: High-energy Particlesmentioning

confidence: 99%

Accessing radiation damage to biomolecules on the nanoscale by particle-scattering simulations

Hahn

2023

J. Phys. Commun.

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“…Survival curves for numerous cell lines exposed to x-rays have been studied for decades, while the studies of cells exposed to proton and heavier ion beams are more recent developments. Most of these studies are experimental even though the theoretical models have appeared in 1950s and have substantially developed since then [1,2,3,4]. The generic look of these curves in semilogarithmic scale (dose on abscissa and logarithm of sell survival probability on ordinate) is parabola-like with the vertex in the origin, corresponding to 100% survival at zero dose.…”

Section: Introductionmentioning

confidence: 99%