Biopolymer-Based Transdermal Films of Donepezil as an Alternative Delivery Approach in Alzheimer’s Disease Treatment

Galipoğlu, Maviye; Erdal, Meryem Sedef; Güngör, Sevgi

doi:10.1208/s12249-014-0224-6

Cited by 26 publications

(10 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These components are responsible for the permeation of a drug. A similar result was reported by using linalool as a permeation enhancer using the drug curcumin [ 14 ]. Galipoğlu et al also showed that limonene, which is a component of coriander oil, increases the permeation of donepezil [ 15 ].…”

Section: Introductionsupporting

confidence: 84%

Fabrication of Tizanidine Loaded Patches Using Flaxseed Oil and Coriander Oil as a Penetration Enhancer for Transdermal Delivery

et al. 2021

View full text Add to dashboard Cite

Transdermal drug delivery is important to maintain plasma drug concentrations for therapeutic efficacy. The current study reports the design, formulation, and evaluation of tizanidine transdermal patches formulated using chitosan and thiolated chitosan, ethyl cellulose (EC), polyvinylpyrrolidone (PVP), and Eudragit RL100 in different ratios. The tizanidine patches were formulated using flaxseed oil and coriander oil in the concentrations of 1% v/w, 2% v/w, 3% v/w, 4% v/w, 5% v/w, and 10% v/w. The patches were subjected to characterization of physicochemical property (thickness, weight uniformity, drug content, efficiency, percentage moisture uptake/loss), in vitro drug release and drug permeation, skin irritation, in vivo application, pharmacokinetics analysis, and stability studies. The results indicate that the interaction of thiolated chitosan with the negative charges of the skin opens the tight junctions of the skin, whereas flaxseed and coriander oils change the conformational domain of the skin. The novelty of this study is in the use of flaxseed and coriander oils as skin permeation enhancers for the formulation of tizanidine transdermal patches. The formulations follow non-Fickian drug release kinetics. The FTZNE23, FTZNE36 and FTZNE54, with 5% v/w flaxseed oil loaded formulations, exhibited higher flux through rabbit skin compared with FTZNE30, FTZNE35, FTZNE42, and FTZNE47, formulations loaded with 10% v/w coriander oil. The study concludes that flaxseed oil is a better choice for formulating tizanidine patches, offering optimal plasma concentration and therapeutic efficacy, and recommends the use of flaxseed and coriander oil based patches as a novel transdermal delivery system for tizanidine and related classes of drugs.

show abstract

Section: Introductionsupporting

confidence: 84%

Fabrication of Tizanidine Loaded Patches Using Flaxseed Oil and Coriander Oil as a Penetration Enhancer for Transdermal Delivery

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Pharmaceutics 2020, 12, x FOR PEER REVIEW 2 of 16 orally; however, significant variations in DH plasma concentrations and gastrointestinal side-effects, including nausea, vomiting, anorexia, and abdominal pain, are associated with oral administration. In addition, owing to dementia and dysphagia, elderly patients have difficult in consuming medicines effectively [8,9]. Thus, transdermal drug delivery systems (TDDSs) can circumvent issues associated with oral administration and may be the best therapeutic platform for improving patient compliance.…”

Section: Molecular Structurementioning

confidence: 99%

Preparation, Characterization, and In Vivo Pharmacokinetic Evaluation of Polyvinyl Alcohol and Polyvinyl Pyrrolidone Blended Hydrogels for Transdermal Delivery of Donepezil HCl

et al. 2020

View full text Add to dashboard Cite

Transdermal delivery systems are emerging platforms for the delivery of donepezil hydrochloride (DH) for treating Alzheimer's disease. The primary aim of this study was to develop polyvinyl alcohol and polyvinyl pyrrolidone blended hydrogels and to evaluate their feasibility for delivering DH via a transdermal route. Physicochemical properties, such as gel fraction (%), swelling ratio (%), weight loss (%), mechanical strength, elongation at break, and Young's modulus of the prepared hydrogels were evaluated. Furthermore, in vitro skin permeation and in vivo pharmacokinetic studies were performed. With an increased concentration of propylene glycol (PG), the gel fraction (%), maximum strength, and elongation at break decreased. However, the swelling ratio (%) and weight loss (%) of hydrogels increased with increased PG content. The 26% PG-hydrogel was superior, with an enhancement ratio of 12.9 (*** p < 0.001). In addition, the 11% PG-hydrogel and 1% PG-hydrogel exhibited an enhancement ratio 6.30-fold (*** p < 0.001) and 2.85-fold (* p < 0.05) higher than that exhibited by control, respectively, indicating a promising effect of PG on skin permeation. In addition, in vivo pharmacokinetic studies on hairless rats assessed the expediency for transdermal delivery of DH. The transdermal delivery of optimized hydrogel-patches with two different doses of DH revealed that the maximum plasma concentration and area under the curve were dose dependent, and the time to reach the maximum concentration was 8 h. Thus, optimized hydrogels have the potential to enhance the transdermal delivery of DH and could be a novel clinical approach.

show abstract

“…Regarding to achieve therapeutic levels of DNP, it seems to be feasible deliver DNP with transdermal films for the management of Alzheimer disease. 29 …”

Section: Dl-limonenementioning

confidence: 99%

Plasticizers: A Vital Excipient in Novel Pharmaceutical Formulations

Mishra

Pathak

2017

Curr. Res. Pharm. Sci.

View full text Add to dashboard Cite

Plasticizers have got significant role in pharmaceutical formulations because of their vital importance in the formulations like gastro-retentive films, ocular films, transdermal films, buccal films, oro-dispersible films. Flexibility, Endurance, Resistibility and Stability which are suitable properties of formulation could be easily achieved by using plasticizers which ultimately imparted desired characteristic in the formulation by the radical use of this excipient. In this review an effort was made to disclose importance, theories and plasticizers mechanism in different novel pharmaceutical formulations to understand its versatility efficiency, utility and tendency to modified different novel pharmaceutical formulations.

show abstract

Biopolymer-Based Transdermal Films of Donepezil as an Alternative Delivery Approach in Alzheimer’s Disease Treatment

Cited by 26 publications

References 42 publications

Fabrication of Tizanidine Loaded Patches Using Flaxseed Oil and Coriander Oil as a Penetration Enhancer for Transdermal Delivery

Fabrication of Tizanidine Loaded Patches Using Flaxseed Oil and Coriander Oil as a Penetration Enhancer for Transdermal Delivery

Preparation, Characterization, and In Vivo Pharmacokinetic Evaluation of Polyvinyl Alcohol and Polyvinyl Pyrrolidone Blended Hydrogels for Transdermal Delivery of Donepezil HCl

Plasticizers: A Vital Excipient in Novel Pharmaceutical Formulations

Contact Info

Product

Resources

About