Biopolymer-supported iron oxide nanocomposite: Preparation and catalytic application in the synthesis of benzodiazepine derivatives

Abstract

Abstract:In this work, cellulose-based nanocomposite containing high contents of Fe 3 O 4 nanoparticles used as a catalyst in the condensation reaction between o-phenylenediamines and ketones for synthesis of benzodiazepines in good to excellent yields under mild conditions. A good correlation between the amount of surface acid sites as well as the surface morphology of the catalysts and the catalytic activity has been observed. This method has been found to be ecofriendly, simple and economical. The solid supported nanocatalyst could be recycled and reused without significant loss of its catalytic activity.