Biopolymeric composite hydrogel loaded with silver NPs and epigallocatechin gallate (EGCG) effectively manages ROS for rapid wound healing in type II diabetic wounds

Kar, Aditya K.; Singh, Amrita; Singh, Divya; Shraogi, Nikita; Verma, Rajendra Kumar; Saji, Joel; Jagdale, Pankaj; Ghosh, Debabrata; Patnaik, Satyakam

doi:10.1016/j.ijbiomac.2022.06.196

Cited by 26 publications

(10 citation statements)

References 61 publications

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“…[ 61,63 ] Kar et al developed Guar Gum‐based macroporous hydrogel (HG) by integrating silver NPs and epigallocatechin gallate (EGCG) to treat diabetic wounds. [ 64 ] This hydrogel exhibited exceptional antibacterial and antioxidant properties. In vivo experiments showed its effectiveness in accelerating wound healing through the promotion of cell proliferation rapid re‐epithelialization.…”

Section: Strategies For Chronic Wounds Healingmentioning

confidence: 99%

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Signaling Pathways Triggering Therapeutic Hydrogels in Promoting Chronic Wound Healing

Chen,

Wu,

Zhang

et al. 2023

Macromolecular Bioscience

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In recent years, there has been a significant increase in the prevalence of chronic wounds, such as pressure ulcers, diabetic foot ulcers, and venous ulcers of the lower extremities. The main contributors to chronic wound formation are bacterial infection, prolonged inflammation, and peripheral vascular disease. However, effectively treating these chronic wounds remains a global challenge. Hydrogels have extensively explored as wound healing dressing because of their excellent biocompatibility and structural similarity to extracellular matrix (ECM). Nonetheless, much is still unknown how the hydrogels promote wound repair and regeneration. Signaling pathways play critical roles in wound healing process by controlling and coordinating cells and biomolecules. Hydrogels, along with their therapeutic ingredients that impact signaling pathways, have the potential to significantly enhance the wound healing process and its ultimate outcomes. Understanding this interaction will undoubtedly provide new insights into developing advanced hydrogels for wound repair and regeneration. This paper reviews the latest studies on classical signaling pathways and potential targets influenced by hydrogel scaffolds in chronic wound healing. This work hopes that it will offer a different perspective in developing more efficient hydrogels for treating chronic wounds.

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Section: Strategies For Chronic Wounds Healingmentioning

confidence: 99%

Section: Strategies For Chronic Wounds Healingmentioning

confidence: 99%

Signaling Pathways Triggering Therapeutic Hydrogels in Promoting Chronic Wound Healing

Chen,

Wu,

Zhang

et al. 2023

Macromolecular Bioscience

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“…25 Kar et al found that a biopolymeric composite hydrogel loaded with AgNPs and epigallocatechin gallate (EGCG) effectively engaged ROS for rapid wound healing in type II diabetic wounds. 26 Haidari et al found that a dual pH-and temperature-responsive silvercontaining hydrogel could precisely eliminate infection and improve wound healing. 27 Also, silver-based biomaterials have many applications in the field of dentistry, such as applications in orthodontic brackets and implant coatings.…”

Section: ■ Introductionmentioning

confidence: 99%

“…A study by Liu et al found that a DNA-Ag hydrogel applied as an antimicrobial dressing exerted its antiseptic effect on wounds and promoted the wound healing . Kar et al found that a biopolymeric composite hydrogel loaded with AgNPs and epigallocatechin gallate (EGCG) effectively engaged ROS for rapid wound healing in type II diabetic wounds . Haidari et al found that a dual pH- and temperature-responsive silver-containing hydrogel could precisely eliminate infection and improve wound healing .…”

Section: Introductionmentioning

confidence: 99%

Super-Rapid In Situ Formation of a Silver Ion-Induced Supramolecular Hydrogel with Efficient Antibacterial Activity for Root Canal Disinfection

Li,

Luo,

et al. 2023

ACS Appl. Mater. Interfaces

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Supramolecular hydrogels prepared using low-molecular-weight gelators have attracted considerable attention for biomedical applications. However, in situ supramolecular hydrogels are limited in terms of their prolonged gelation time and/or unstable nature at high temperatures. In this study, we constructed a stable supramolecular Ag-isoG hydrogel through super-rapid in situ formation, wherein hydrogelation process occurred instantaneously upon mixing isoG and Ag+ within 1 s under ambient conditions. Interestingly, unlike most nucleoside-based supramolecular hydrogels, this Ag-isoG hydrogel remains stable even at a high temperature (100 °C). Moreover, the as-designed hydrogel demonstrated significant antibacterial activity against Staphylococcus aureus and the oral bacterium Streptococcus mutans owing to the strong chelating ability of Ag ions, and the hydrogel exhibited relatively low cytotoxicity in root canal and an easy removal feature by saline. The hydrogel was then applied to a root canal infection model, which demonstrated strong antibacterial activity against Enterococcus faecalis, with performance even better than that of the regular calcium hydroxide paste. This feature makes the Ag-isoG hydrogel a prospective alternative material as intracanal medicaments for root canal treatment.

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“…Moreover, this hydrogel can respond to the elevated levels of reactive oxygen species (ROS) in the wound microenvironment and undergo spontaneous degradation, thereby releasing the loaded drugs. [30][31][32] Therefore, it is an ideal material for encapsulating tEVs and GSNO in this project.…”

Section: Introductionmentioning

confidence: 99%

Synergistic wound repair effects of a composite hydrogel for delivering tumor-derived vesicles and S-nitrosoglutathione

Nan,

Wang,

Wang

et al. 2023

J. Mater. Chem. B

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Biopolymeric composite hydrogel loaded with silver NPs and epigallocatechin gallate (EGCG) effectively manages ROS for rapid wound healing in type II diabetic wounds

Cited by 26 publications

References 61 publications

Signaling Pathways Triggering Therapeutic Hydrogels in Promoting Chronic Wound Healing

Signaling Pathways Triggering Therapeutic Hydrogels in Promoting Chronic Wound Healing

Super-Rapid In Situ Formation of a Silver Ion-Induced Supramolecular Hydrogel with Efficient Antibacterial Activity for Root Canal Disinfection

Synergistic wound repair effects of a composite hydrogel for delivering tumor-derived vesicles and S-nitrosoglutathione

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