Biopolymers in Medical Implants: A Brief Review

Rebelo, Rita; Fernandes, Margarida M.; Fangueiro, Raúl

doi:10.1016/j.proeng.2017.07.034

Cited by 216 publications

(106 citation statements)

References 27 publications

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“…Another source for preparing the medical implants is the synthetic material group. In order to reinforce the weakness in mechanical features of natural materials, synthetic biomaterials have been used in combination to provide scaffolds with ideal chemical and mechanical properties . On the other hand, hydrophobicity and lack of bioactivity of synthetic materials may result in unfavorable cellular responses and poor cell–matrix interactions .…”

Section: Effects Of Bulk Properties On Cellular Behaviormentioning

confidence: 99%

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Amani

Arzaghi

Bayandori

et al. 2019

Adv Materials Inter

321

200

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Surface interaction at the biomaterial–cell interface is essential for a variety of cellular functions, such as adhesion, proliferation, and differentiation. Nevertheless, changes in the biointerface enable to trigger specific cell signaling and result in different cellular responses. In order to manufacture biomaterials with higher functionality, biomaterials containing immobilized bioactive ligands have been widely introduced and employed for tissue engineering and regenerative medicine applications. Moreover, a number of physical and chemical strategies have been used to improve the functionality of biomaterials and specifically at the material interface. Here, the interactions between materials and cells at the interface levels are described. Then, the importance of surface properties in cell function is discussed and recent methods for surface modifications are systematically highlighted. Additionally, the impact of bulk material properties on the cellular responses is briefly reviewed.

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Section: Effects Of Bulk Properties On Cellular Behaviormentioning

confidence: 99%

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Amani

Arzaghi

Bayandori

et al. 2019

Adv Materials Inter

321

200

View full text Add to dashboard Cite

show abstract

“…Traditional materials for aerogel preparation like silica, carbon, metals, and synthetic polymers present some drawbacks that limit their use in biomedical applications. These drawbacks include immunological rejection by the body and their high cytotoxicity, which may cause undesirable immunogenic response [ 13 ]. The studies on biopolymers are motivated by the search for sustainable precursors instead of using traditional oil-based or synthetic materials [ 10 ].…”

Section: Biopolymer-based Aerogelsmentioning

confidence: 99%

A Review on Revolutionary Natural Biopolymer-Based Aerogels for Antibacterial Delivery

et al. 2020

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A biopolymer-based aerogel has been developed to become one of the most potentially utilized materials in different biomedical applications. The biopolymer-based aerogel has unique physical, chemical, and mechanical properties and these properties are used in tissue engineering, biosensing, diagnostic, medical implant and drug delivery applications. Biocompatible and non-toxic biopolymers such as chitosan, cellulose and alginates have been used to deliver antibiotics, plants extract, essential oils and metallic nanoparticles. Antibacterial aerogels have been used in superficial and chronic wound healing as dressing sheets. This review critically analyses the utilization of biopolymer-based aerogels in antibacterial delivery. The analysis shows the relationship between their properties and their applications in the wound healing process. Furthermore, highlights of the potentials, challenges and proposition of the application of biopolymer-based aerogels is explored.

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“…29,31,[33][34][35] Among all available sources of materials, capsule shells made of biopolymers have increasingly gained a lot of research interest because of their biodegradability, biocompatibility and environmental friendly character. [36][37][38][39][40][41] These polymers can be obtained from plants and living microorganisms. They are widely used in the biomedical, packaging, cosmetic, fabric and agricultural industries.…”

Section: Introductionmentioning

confidence: 99%

High performance biocompatible cellulose‐based microcapsules encapsulating gallic acid prepared by inverse microsuspension polymerization

Tangsongcharoen

Punyamoonwongsa

Chaiyasat

2019

Polymer International

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In this study, the preparation of biocompatible cellulose‐based microcapsules encapsulating gallic acid (GA), an important antioxidant of Bambara groundnut extracts, by water‐in‐oil inverse microsuspension polymerization was studied. GA and carboxymethyl cellulose (CMC) were selected as core and shell materials, respectively. For high encapsulation efficiency, CMC was firstly modified (modified‐CMC (m‐CMC)) with 3‐(trimethoxysilyl)propyl methacrylate (MPS) as a silane coupling agent. It was subsequently polymerized with methacrylic acid (MAA) monomer through a radical route, forming a PMAA grafted m‐CMC (m‐CMC‐g‐PMAA) biocompatible polymer shell. Using CMC:MPS in a ratio of 75:25 (w/w %), highly water‐soluble m‐CMC containing a C=C bond for further radical polymerization was obtained. After inverse microsuspension polymerization at various ratios of m‐CMC:MAA, highly stable spherical m‐CMC‐g‐PMAA microcapsules encapsulating GA were formed in all ratios. It was observed that the encapsulation efficiency increased with increase in MAA content. m‐CMC:MAA in a ratio of 33:67 (w/w%) presented the highest encapsulation efficiency which may due to the increase of hydrophilicity of the aqueous phase. It also presented rapid release and non‐cytotoxic characteristics, suited for use in cosmetic products. © 2018 Society of Chemical Industry

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Biopolymers in Medical Implants: A Brief Review

Cited by 216 publications

References 27 publications

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

A Review on Revolutionary Natural Biopolymer-Based Aerogels for Antibacterial Delivery

High performance biocompatible cellulose‐based microcapsules encapsulating gallic acid prepared by inverse microsuspension polymerization

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