Bioreabsorbable polymers for tissue engineering: PLA, PGA, and their copolymers

Benatti, Ana Carolina Bueno; Pattaro, Ana Flávia; Rodrigues, Ana Amélia; Xavier, Michelle da Cunha Abreu; Kaasi, Andreas; Barbosa, María Emanuella Firmino; Jardini, André Luiz; Filho, Rubens Maciel; Kharmandayan, Paulo

doi:10.1016/b978-0-12-816901-8.00004-3

Cited by 18 publications

(13 citation statements)

References 85 publications

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“…The pellets of PLA (3D850) obtained from Nature-WorksÒ LLC and were used for filament fabrication. PCL was supplied by Sigma-Aldrich (product number 440744) and has a molecular weight of * 80000 g/mol and a density of 1.14 g/cm 3 . HNT used in this study was supplied by Sigma-Aldrich and has an average outer diameter of * 50 nm (see, TEM image shown in Fig.…”

Section: Experimental Materialsmentioning

confidence: 99%

“…Both PLA and PCL are regarded as biomedical materials by Food and Drug Administration USA, due to their biocompatibility [1,2]. The end-product obtained after biodegradation of PLA, such as water, carbon dioxide and hydroxyl acid, is well accepted by the human body [3,4]. Although PLA has adequate strength, it lacks mechanical compliance [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Architected poly(lactic acid)/poly(ε-caprolactone)/halloysite nanotube composite scaffolds enabled by 3D printing for biomedical applications

Alam

Verma

Mohammad³

et al. 2021

J Mater Sci

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Herein, we report the physicochemical, thermal, mechanical and biological characteristics, including bioactivity, biodegradation and cytocompatibility of additive manufacturing-enabled novel nanocomposite scaffolds. The scaffolds comprise a blend of polylactic acid (PLA) and poly-ε-caprolactone (PCL) reinforced with halloysite nanotubes (HNTs). The nanoengineered filaments were developed by melt blending, and the nanocomposite scaffolds were manufactured by fused filament fabrication. Uniform dispersion of HNTs in the PLA/PCL blend is revealed via scanning electron microscopy. Mechanical property loss due to the addition of PCL to realize a suitable biodegradation rate of PLA was fully recovered by the addition of HNTs. Bioactivity, as revealed by the fraction of apatite growth quantified from XRD analysis, was 5.4, 6.3, 6.8 and 7.1% for PLA, 3, 5 and 7 wt% HNT in PLA/PCL blend, respectively, evidencing enhancement in the bioactivity. The degradation rate, in terms of weight loss, was reduced from 4.6% (PLA) to 1.3% (PLA/PCL) upon addition of PCL, which gradually increased to 4.4% by the addition of HNTs (at 7 wt% HNT). The results suggest that the biodegradation rate, mechanical properties and biological characteristics, including cytocompatibility and cell adhesion, of the 3D printed, microarchitected PLA/PCL/HNT composite scaffolds can be tuned by an appropriate combination of HNT and PCL content in the PLA matrix, demonstrating their promise for bone replacement and regeneration applications. Graphical abstract

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Section: Experimental Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Architected poly(lactic acid)/poly(ε-caprolactone)/halloysite nanotube composite scaffolds enabled by 3D printing for biomedical applications

Alam

Verma

Mohammad³

et al. 2021

J Mater Sci

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“…Despite its characteristics, the synthesis of PGA remains extremely expensive compared to that of PLA [61]. For PGA, as for almost all polymers, the mechanical properties vary with crystallinity degree [49]. Compared to other polymers used for vascular stent manufacturing, such as PLLA and PLGA, PGA presents better tensile strength and stiffness, as demonstrated in Table 2.…”

Section: Poly(glycolic Acid)mentioning

confidence: 99%

“…PLA is acquired and synthesized from lactic acid or lactide. This compound is considered a renewable source since it is extracted from corn starch or sugar cane [ 48 , 49 ]. The biodegradable polymer can be synthesized using different routes: ring-opening polymerization (ROP) or polycondensation of lactide ( Figure 5 ) [ 50 , 51 ].…”

Section: Polymeric Materials For Bioresorbable Vascular Stentsmentioning

confidence: 99%

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3D Printing of Polymeric Bioresorbable Stents: A Strategy to Improve Both Cellular Compatibility and Mechanical Properties

2022

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One of the leading causes of death is cardiovascular disease, and the most common cardiovascular disease is coronary artery disease. Percutaneous coronary intervention and vascular stents have emerged as a solution to treat coronary artery disease. Nowadays, several types of vascular stents share the same purpose: to reduce the percentage of restenosis, thrombosis, and neointimal hyperplasia and supply mechanical support to the blood vessels. Despite the numerous efforts to create an ideal stent, there is no coronary stent that simultaneously presents the appropriate cellular compatibility and mechanical properties to avoid stent collapse and failure. One of the emerging approaches to solve these problems is improving the mechanical performance of polymeric bioresorbable stents produced through additive manufacturing. Although there have been numerous studies in this field, normalized control parameters for 3D-printed polymeric vascular stents fabrication are absent. The present paper aims to present an overview of the current types of stents and the main polymeric materials used to fabricate the bioresorbable vascular stents. Furthermore, a detailed description of the printing parameters’ influence on the mechanical performance and degradation profile of polymeric bioresorbable stents is presented.

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Bioactive Glasses in Orthopedics

Houaoui¹,

Massera²

2022

Biofabrication for Orthopedics

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Bioreabsorbable polymers for tissue engineering: PLA, PGA, and their copolymers

Cited by 18 publications

References 85 publications

Architected poly(lactic acid)/poly(ε-caprolactone)/halloysite nanotube composite scaffolds enabled by 3D printing for biomedical applications

Architected poly(lactic acid)/poly(ε-caprolactone)/halloysite nanotube composite scaffolds enabled by 3D printing for biomedical applications

3D Printing of Polymeric Bioresorbable Stents: A Strategy to Improve Both Cellular Compatibility and Mechanical Properties

Bioactive Glasses in Orthopedics

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