Bioreactor-Based Tissue Models as an Alternative Approach in Cancer Research

Bişgin, Atıl; Mujde, Cem

doi:10.1007/978-981-19-1282-5_12-1

Cited by 1 publication

(1 citation statement)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Static methods for obtaining and maintaining in vitro 3D cell cultures such as spheroids (e.g., the liquid overlay method) have the disadvantage of offering transport based solely on diffusion. In order to mitigate the transport effect in 3D cell cultures, micro-channel systems [ 158 , 159 , 160 , 161 ] or stirring bioreactors can be used [ 161 , 162 , 163 , 164 ]. Stirred bioreactors promote uniform circulation of the culture medium around spheroids [ 164 ], while microchannel systems facilitate the controlled and precise transport of nutrients and oxygen to cells [ 165 ].…”

Section: Immunohistological Studies For Complex Biological Structuresmentioning

confidence: 99%

Unveiling Nanoparticles: Recent Approaches in Studying the Internalization Pattern of Iron Oxide Nanoparticles in Mono- and Multicellular Biological Structures

Petcov,

Straticiuc,

Iancu

et al. 2024

JFB

View full text Add to dashboard Cite

Nanoparticle (NP)-based solutions for oncotherapy promise an improved efficiency of the anticancer response, as well as higher comfort for the patient. The current advancements in cancer treatment based on nanotechnology exploit the ability of these systems to pass biological barriers to target the tumor cell, as well as tumor cell organelles. In particular, iron oxide NPs are being clinically employed in oncological management due to this ability. When designing an efficient anti-cancer therapy based on NPs, it is important to know and to modulate the phenomena which take place during the interaction of the NPs with the tumor cells, as well as the normal tissues. In this regard, our review is focused on highlighting different approaches to studying the internalization patterns of iron oxide NPs in simple and complex 2D and 3D in vitro cell models, as well as in living tissues, in order to investigate the functionality of an NP-based treatment.

show abstract