Bioresponsive Chimaeric Polymersomes Mediate Sustained and Liver-Specific siRNA Transfection In Vivo
Ri Huang,
Feifei Wang,
He Fu
et al.
Abstract:The silencing of disease-causing
genes with small interfering RNA (siRNA) offers a
particularly effective therapeutic strategy for different disorders;
however, its clinical efficacy relies on the development of nontoxic
and tissue-specific delivery vehicles. Herein, we report that bioresponsive
chimaeric polymersomes (BCP) with short poly(ethylenimine) as inner
shell mediate highly efficacious, sustained, and liver-specific siRNA transfection in vivo. BCP exhibited
remarkable encapsulation efficiencies of si… Show more
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