Biosensing chips for cancer diagnosis and treatment: a new wave towards clinical innovation

Abstract

Recent technological advances in nanoscience and material designing have led to the development of point-of-care devices for biomolecule sensing and cancer diagnosis. In situ and portable sensing devices for bedside, diagnosis can effectively improve the patient’s clinical outcomes and reduce the mortality rate. Detection of exosomal RNAs by immuno-biochip with increased sensitivity and specificity to diagnose cancer has raised the understanding of the tumor microenvironment and many other technology-based biosensing devices hold great promise for clinical innovations to conquer the unbeatable fort of cancer metastasis. Electrochemical biosensors are the most sensitive category of biomolecule detection sensors with significantly low concentrations down to the atomic level. In this sense, this review addresses the recent advances in cancer detection and diagnosis by developing significant biological sensing devices that are believed to have better sensing potential than existing facilities.

An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms

“…Chronic inflammation can induce tumorigenesis by initiating and perpetuating local inflammatory processes that promote the proliferation and dissemination of tumor cells. Therefore, inflammatory pathways may be targeted by alternariol in an attempt to control cancer ( Ali et al, 2022a ; Hossain et al, 2022 ; Iqbal et al, 2022 ).…”

Paper-Based Analytical Devices for Cancer Liquid Biopsy

“…They use paper-based substrates with bioreceptors to capture cancer biomarkers in liquid biopsies for electrochemical detection. − Cost-effective, portable, paper-based electrochemical biosensors are convenient for applications in LMICs. These sensors employ electrodes developed from conductive inks, carbon components, or metal nanoparticles to detect and quantify cancer biomarkers. − Smartphone integration improves the functionality of paper-based electrochemical sensors for real-world use …”

Anticancer properties of bromelain: State-of-the-art and recent trends

“…In the case of cancer, this process has a dual activity, since it is capable of promoting the survival of cancer cells, through protective autophagy, or participating in the death of these cells, inducing cytotoxic autophagy ( 116 , 117 ). In normal tissues, autophagy at the basal level is necessary as it provides housekeeping functions as well as increased apoptosis ( 118 , 119 ). Even in periods of stress and hunger, the autophagy process is necessary ( 120 ).…”