Biosensing methods for determination of creatinine: A review

Pundir, C.S.; Kumar, Parveen; Jaiwal, Ranjana

doi:10.1016/j.bios.2018.11.031

Cited by 117 publications

(45 citation statements)

References 128 publications

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“…As with dehydration, changes in blood volume could affect the present results; this was solved by ensuring participants had a systolic blood pressure below 150 mmHg and above 80 mmHg before entering the COVID-19 zone. The measurement of creatinine using POCT is reliable, fast, and performed with a simple venous analysis or capillary blood sample [33,34]. In addition to our results, this may be helpful in anticipating and knowing which workers are more likely to develop a headache while wearing PPEs.…”

Section: Discussionmentioning

confidence: 57%

Blood Biomarkers for Assessing Headaches in Healthcare Workers after Wearing Biological Personal Protective Equipment in a COVID-19 Field Hospital

Martin-Rodríguez

López-Izquierdo

Rubiales

et al. 2021

JPM

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The coronavirus disease 2019 (COVID-19) has led to a pandemic, which among other things, has highlighted biosafety as a key cornerstone in the management of disease transmission. The aim of this work was to analyze the role played by different blood biomarkers in predicting the appearance of headaches in healthcare workers wearing personal protective equipment (PPE) in a COVID-19 treatment unit. A prospective cohort study of 38 healthcare workers was performed during April 2020. Blood analysis, performed just before the start of a 4 hour shift, was carried out on all volunteers equipped with PPE. At the end of their shifts and after decontamination, they were asked if they had suffered from headache in order to obtain a binary outcome. The baseline creatinine value reflected a specific odds ratio of 241.36 (95% CI: 2.50–23,295.43; p = 0.019) and an area under the curve (AUC) value of 0.737 (95%CI: 0.57–0.90; p < 0.01). Blood creatinine is a good candidate for predicting the appearance of a de novo headache in healthcare workers after wearing PPE for four hours in a COVID-19 unit.

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Section: Discussionmentioning

confidence: 57%

Blood Biomarkers for Assessing Headaches in Healthcare Workers after Wearing Biological Personal Protective Equipment in a COVID-19 Field Hospital

Martin-Rodríguez

López-Izquierdo

Rubiales

et al. 2021

JPM

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“…Various studies, such as those by Gozubatik-Celik G et al (27), in patients during dialysis, or by Poyrazoğlu HG et al (28) in an infant population, have already described this correlation between creatinine and the appearance of headaches. It should be noted that the assessment of creatinine levels using POCT is a reliable and fast method and it is performed with a simple venous analysis or capillary blood sample (29) (30). In this sense, dehydration has been related to a headache increase (31) and also to creatinine levels increase (32).…”

Section: Discussionmentioning

confidence: 99%

Blood biomarkers for assessing headaches in healthcare workers after wearing biological personal protective equipment in a COVID-19 field-hospital

Martin-Rodríguez¹,

Rubiales²,

Millán³

et al. 2020

Preprint

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The consequences of wearing biosafety equipment by healthcare professionals during their work and the prediction of such consequences need to be assessed. To analyze the role played by different blood biomarkers in predicting the appearance of headaches in healthcare workers wearing personal protective equipment (PPE) in a COVID-19 treatment unit, a Prospective cohort study of 38 healthcare workers from a convalescence unit of patients with COVID-19 in a field hospital was performed during April 2020. Blood analysis was carried out before the start of the 4 hours shift of the volunteers equipped with PPE. After decontamination, there were asked if they had suffered from headache, obtaining the binary outcome. This study included 38 participants with a median age of 29 years (25th-75th percentile: 26-44 years old), 73.7% female (28 cases). 44.7% (17 cases) had a headache after wearing PPE for 4 hours. The baseline creatinine value reflected a specific odds ratio in the regression model of 241.36 (95% CI: 2.50-23,295.43; p=0.019), and an AUC of 0.737 (95%CI: 0.57-0.90; p<0.01). Blood creatinine is a good candidate for predicting the appearance of a de novo headache in healthcare workers after wearing PPE for 4 hours in a COVID – 19 unit.

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“…Although the two indicators eGFR CysC and eGFR Creat were both applied in the Chinese group, our findings showed that eGFR CysC had a higher performance in the diagnosis of kidney impairment in LNA. Moreover, the evidence is available that the measurement of Creat to determine the eGFR is limited by the influence of age and sex, as well as the variability in the clinical methodology for Creat determination [34, 35]. As known, the enzyme method is widely used in the majority of laboratories.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic performance of serum cystatin C and complement component 1q in lupus nephritis

Zhang

Yang

et al. 2019

Arthritis Res Ther

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BackgroundThe information concerning non-invasive, easily obtainable, and accurate biomarkers for diagnosis of lupus nephritis (LN) is extremely limited. The aim of this study was to evaluate the diagnostic performance of cystatin C (CysC) and complement component 1q (C1q) for LN.MethodsA case-control study that included 905 patients with systemic lupus erythematosus (SLE) without LN (group SLE), 334 patients with active lupus nephritis (group LNA), 255 patients with inactive lupus nephritis (group LNI), and 497 healthy individuals (group HC) was performed in Mianyang Central Hospital from March 2017 to December 2018. The serum levels of CysC, C1q, urea (Urea), and creatinine (Creat) were measured, and 2 estimated glomerular filtration rates (eGFRCysC and eGFRCreat) were calculated by equations which were based on serum CysC established by our group and the modification of diet in renal disease (MDRD), respectively. ANOVA analysis or Kruskal-Wallis test was used for comparing the differences among the groups, and receiver operating characteristic (ROC) curve was applied to identify the diagnostic efficiencies of individual or combined multiple indicators.ResultsSignificantly elevated CysC and decreased C1q were observed in the LNA and LNI groups, which was in contrast to their levels in the SLE and HC groups. CysC (AUC = 0.906) or eGFRCysC (AUC = 0.907) assessed the highest diagnostic performance on LNA when detected individually, followed by C1q (AUC = 0.753). Joint utilization of C1q and CysC achieved very good performance (AUC = 0.933) which approximated to the best one observed in the combinations of C1q, Urea, CysC, eGFRCreat, and Creat (AUC = 0.975).ConclusionThe separately detected CysC (eGFRCysC) and C1q were superior to the conventional biomarkers Urea, Creat, and eGFRCreat in the diagnosis of LNA. Moreover, although the combined detection of Urea, Creat, C1q, CysC, and eGFRCreat had the greatest diagnostic performance, the joint utilization of CysC and C1q could be prioritized for rapid discrimination of LNA if the economic burden is taken into consideration.

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Biosensing methods for determination of creatinine: A review

Cited by 117 publications

References 128 publications

Blood Biomarkers for Assessing Headaches in Healthcare Workers after Wearing Biological Personal Protective Equipment in a COVID-19 Field Hospital

Blood Biomarkers for Assessing Headaches in Healthcare Workers after Wearing Biological Personal Protective Equipment in a COVID-19 Field Hospital

Blood biomarkers for assessing headaches in healthcare workers after wearing biological personal protective equipment in a COVID-19 field-hospital

Diagnostic performance of serum cystatin C and complement component 1q in lupus nephritis

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