Biosensing of prostate specific antigen (PSA) in human plasma samples using biomacromolecule encapsulation into KCC-1-npr-NH2: A new platform for prostate cancer detection

Abbasy, Leila; Mohammadzadeh, Arezoo; Hasanzadeh, Mohammad; Ehsani, Maryam; Mokhtarzadeh, Ahad

doi:10.1016/j.ijbiomac.2020.03.093

Cited by 8 publications

(3 citation statements)

References 38 publications

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“…For example, Bayal et al [60] showed that changing the concentrations of urea, surfactant (CTAB instead of CPB), or solvent (1-pentanol), the reaction time, or temperature can result in various particle sizes, fiber densities, surface areas, and pore volumes for KCC-1. Such easy manipulation and controlled synthesis of this material make KCC-1 a good solution for versatile applications in the environment, energy, biology, medicine, and other fields [42,43,[61][62][63][64][65][66][67][68]. KCC-1 could be recommended for different small or large drug/therapeutic agents, possibly for any design and pathological disorder due to KCC-1 s unique physicochemical features.…”

Section: Discovery Synthesis and Properties Of Msnsmentioning

confidence: 99%

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

AbouAitah

Łojkowski

2021

Pharmaceutics

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Natural prodrugs derived from different natural origins (e.g., medicinal plants, microbes, animals) have a long history in traditional medicine. They exhibit a broad range of pharmacological activities, including anticancer effects in vitro and in vivo. They have potential as safe, cost-effective treatments with few side effects, but are lacking in solubility, bioavailability, specific targeting and have short half-lives. These are barriers to clinical application. Nanomedicine has the potential to offer solutions to circumvent these limitations and allow the use of natural pro-drugs in cancer therapy. Mesoporous silica nanoparticles (MSNs) of various morphology have attracted considerable attention in the search for targeted drug delivery systems. MSNs are characterized by chemical stability, easy synthesis and functionalization, large surface area, tunable pore sizes and volumes, good biocompatibility, controlled drug release under different conditions, and high drug-loading capacity, enabling multifunctional purposes. In vivo pre-clinical evaluations, a significant majority of results indicate the safety profile of MSNs if they are synthesized in an optimized way. Here, we present an overview of synthesis methods, possible surface functionalization, cellular uptake, biodistribution, toxicity, loading strategies, delivery designs with controlled release, and cancer targeting and discuss the future of anticancer nanotechnology-based natural prodrug delivery systems.

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Section: Discovery Synthesis and Properties Of Msnsmentioning

confidence: 99%

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

AbouAitah

Łojkowski

2021

Pharmaceutics

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“…KCC-1 and KCC-1-NH 2 were synthesized following the technique described in our prior research [ 18 ]. Dithiocarbamate functionalized KCC-1-NH 2 as follows: 100 mg of CS 2 was dissolved in 20 mL of acetonitrile containing 1 percent Et 3 N and 90 mg of KCC-1-NH 2 .…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, porous materials offer a broad range of applications in material science, serving as remarkable building blocks for the advancement of several technologies [ 18 ]. Silica’s usage as a porous material is widely established due to its advantageous qualities such as low density, low toxicity with high biocompatibility, ease of surface modification, stability, and low cost [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Efficient Entrapment of Alpha-Synuclein Biotinylated Antibody in KCC-1-NH-CS2 and Application for the Sensitive Diagnosis of Parkinson’s Using Recognition of Biomarker: An Innovative Electrochemical Label-Free Immunosensor for the Biomedical Analysis of Neurodegenerative Diseases

et al. 2022

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The early detection of Parkinson’s disease (PD) is a critical issue in terms of efficiency. Alpha-synuclein (α-Syn) is a biomarker in PD checks. Alpha-synuclein (α-syn) is the major constituent of Lewy bodies and a pathogenic hallmark of all synucleinopathies, including PDs, dementia with Lewy bodies, and multiple system atrophy. In this study, KCC-1-NH-CS2 was conjugated with biotinylated Ab and entrapped in P(β-CD) polymer cavities. Using this approach, a novel electrochemical label-free immunosensor was designed for the quantification of α-syn in real human samples. For this purpose, the glassy carbon electrode electropolymerized with P(β-CD) biopolymer provided an excellent matrix for entrapping of KCC-1-NH-CS2 loaded with the biotinylated antibody of α-syn. Using the chronoamperometric technique, the proposed immunosensor shows a suitable range of 0.02 to 64 ng/mL for the determination of α-syn. Additionally, a low limit of quantification of the engineered biosensor was obtained at 0.02 ng/mL. The developed immunosensor’s adequate stability, sensitivity, and selectivity, together with its ease of manufacture, make it a promising diagnostic technique for further research. This study also will pave the way for further applications of the synergetic effect of β-CD and KCC-1-NH-CS2 for biomedical analysis in the near future.

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A label-free photoelectrochemical immunosensor for prostate specific antigen detection based on Ag2S sensitized Ag/AgBr/BiOBr heterojunction by in-situ growth method

Zhu

Chang

et al. 2021

Bioelectrochemistry

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Biosensing of prostate specific antigen (PSA) in human plasma samples using biomacromolecule encapsulation into KCC-1-npr-NH2: A new platform for prostate cancer detection

Cited by 8 publications

References 38 publications

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

Efficient Entrapment of Alpha-Synuclein Biotinylated Antibody in KCC-1-NH-CS2 and Application for the Sensitive Diagnosis of Parkinson’s Using Recognition of Biomarker: An Innovative Electrochemical Label-Free Immunosensor for the Biomedical Analysis of Neurodegenerative Diseases

A label-free photoelectrochemical immunosensor for prostate specific antigen detection based on Ag2S sensitized Ag/AgBr/BiOBr heterojunction by in-situ growth method

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