Biosensors Based on Nanoparticles and Electrochemical Detection

Polo, Ester; Puertas, Sara; Batalla, Pilar

doi:10.1016/b978-0-12-415769-9.00010-8

Cited by 3 publications

(2 citation statements)

References 110 publications

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“…In the Western countries, gold has been used to treat nervous disorder and epilepsy. No toxicity was reported for its use in both in vitro and in vivo studies [ 8 , 44 , 45 ]. Since then, oral and injectable gold compounds continued to be used as treatments for arthritis [ 9 , 46 ] and have also been shown to have anticancer effects [ 8 ].…”

Section: Biological Application Of Aunpsmentioning

confidence: 99%

Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review

et al. 2021

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The medical properties of metals have been explored for centuries in traditional medicine for the treatment of infections and diseases and still practiced to date. Platinum-based drugs are the first class of metal-based drugs to be clinically used as anticancer agents following the approval of cisplatin by the United States Food and Drug Administration (FDA) over 40 years ago. Since then, more metals with health benefits have been approved for clinical trials. Interestingly, when these metals are reduced to metallic nanoparticles, they displayed unique and novel properties that were superior to their bulk counterparts. Gold nanoparticles (AuNPs) are among the FDA-approved metallic nanoparticles and have shown great promise in a variety of roles in medicine. They were used as drug delivery, photothermal (PT), contrast, therapeutic, radiosensitizing, and gene transfection agents. Their biomedical applications are reviewed herein, covering their potential use in disease diagnosis and therapy. Some of the AuNP-based systems that are approved for clinical trials are also discussed, as well as the potential health threats of AuNPs and some strategies that can be used to improve their biocompatibility. The reviewed studies offer proof of principle that AuNP-based systems could potentially be used alone or in combination with the conventional systems to improve their efficacy.

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Section: Biological Application Of Aunpsmentioning

confidence: 99%

Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review

et al. 2021

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“…Although label-based electrochemical amplication strategies are extremely sensitive with detection of target down to femtogram level and able to detect more than one analyte simultaneously, their complicated fabrication, high assay cost and long analysis time hinder their practical application. 104…”

Section: Multi-step Enhancement Strategiesmentioning

confidence: 99%