Biosensors for Odor Detection: A Review

Deng, Hongchao; Nakamoto, Takamichi

doi:10.3390/bios13121000

Cited by 4 publications

(1 citation statement)

References 181 publications

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“…2,3) In recent years, biosensors based on olfactory and taste receptors have been developed. [4][5][6][7] In addition, devices that present chemical sensations, such as olfactory [8][9][10] and taste displays, 11,12) have been produced, and the development of sensors that can detect smells and tastes to produce digital information 13) is an important element of these technologies.…”

Section: Introductionmentioning

confidence: 99%

A microfluidic sensor for continuously measuring membrane potential changes in interactions between taste substances and lipid polymer membranes

Tahara,

Kikuya,

Okada

et al. 2024

Jpn. J. Appl. Phys.

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To evaluate the taste changes experienced by humans over time, we developed a microfluidic sensor for continuously measuring membrane potential changes in interactions between taste substances and lipid polymer membranes. The performance of the proposed sensing device was evaluated by determining the dependence on concentration using tannic acid (astringency substance) solutions and measuring the selectivity using other taste quality samples. Furthermore, to demonstrate the practicality of the sensor, we measured three samples of red wine. The fabricated microfluidic sensor could measure changes in membrane potential over time. Moreover, the fabricated microfluidic sensor was shown to have high selectivity comparable to that of the commercialized sensor. In addition, measurements were performed on red wine as a real sample, and the membrane potential response over time was measured for several different wines. Thus, it was shown that a new sensor for objectively quantifying changes in taste perceived by humans over time could be realized.

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Section: Introductionmentioning

confidence: 99%

A microfluidic sensor for continuously measuring membrane potential changes in interactions between taste substances and lipid polymer membranes

Tahara,

Kikuya,

Okada

et al. 2024

Jpn. J. Appl. Phys.

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Odor Biosensors Based on Cell Expressing Olfactory Receptor: Recent Advances

Deng,

Nakamoto

2024

Analysis & Sensing

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Inspired by the powerful biological olfaction, scientists extracted numerous materials such as olfactory sensory neuron, olfactory receptor (OR) protein, and odorant binding protein from animal olfactory systems, then combined them with transducers to form multiple odor biosensors. These biosensors, despite well inheriting the sensing ability of creatures, have several drawbacks, such as complex preparation process, unstable sensing material characteristics, and high cost. Unlike the biological materials listed above, cell expressing heterologous OR maintains a stable sensing performance after passaging for multiple generations, also its experimental operation is simple, and cost is low. Therefore, odor biosensors based on cell expressing OR have been well developed in recent years. In this review, we first listed several odor biosensors based on cell expressing OR, mainly focusing on fluorescent and electrophysiological measurement methods. Furthermore, we illustrated the techniques to improve the biosensor performance, e.g., wider detection range, longer lifetime, more OR types, and higher quantification efficiency. In addition, we explained the possible prospects such as big sensor array and predicting odor response.

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