Biostable electrospun microfibrous scaffolds mitigate hypertrophic scar contraction in an immune-competent murine model

Lorden, Elizabeth R.; Miller, Keith L.; Ibrahim, Mohamed M.; Bashirov, Latif; Hammett, Ellen; Chakraborty, Samarshi; Quiles-Torres, Carlos; Ma, Sisi; Leong, Kam W.; Levinson, Howard

doi:10.1016/j.actbio.2015.12.025

Cited by 31 publications

(25 citation statements)

References 56 publications

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“…Mast cells have been implicated in fibrosis and scarring [58,59,60], making them a potential target for therapies. Polyurethane scaffolds are also in consideration in the reduction of hypertrophic scars as implantation of a scaffold in debrided murine burn injuries reduced the rigidity of the formed scar tissue [542].…”

Section: Wound Complicationsmentioning

confidence: 99%

The Dynamics of the Skin’s Immune System

Nguyen

Soulika

2019

IJMS

468

339

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The skin is a complex organ that has devised numerous strategies, such as physical, chemical, and microbiological barriers, to protect the host from external insults. In addition, the skin contains an intricate network of immune cells resident to the tissue, crucial for host defense as well as tissue homeostasis. In the event of an insult, the skin-resident immune cells are crucial not only for prevention of infection but also for tissue reconstruction. Deregulation of immune responses often leads to impaired healing and poor tissue restoration and function. In this review, we will discuss the defensive components of the skin and focus on the function of skin-resident immune cells in homeostasis and their role in wound healing.

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Section: Wound Complicationsmentioning

confidence: 99%

The Dynamics of the Skin’s Immune System

Nguyen

Soulika

2019

IJMS

468

339

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“…The putative advantages of pressure treatment include its ability a. to occlude capillaries, resulting in a lack of oxygen, which accelerates the maturation of the scar [54]; b. to hasten the maturation process [34]; c. to reduce scar thickness; d. to increase scar elasticity; e. to reduce scar bleeding; f. to reduce edema [36]; g. to make collagen and rearrange epidermal tissue [36]; h. to reduce the rate of collagen synthesis [1]; i. to reduce pruritus associated with immature hypertrophic scars [36]; and j. to prevent the formation of contractures over flexor joints [63].…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of Fitting Pressure Garments for Minor and Moderate Burn Patients

Huang

2017

Proceedings of the 2017 4th International Conference on Biomedical and Bioinformatics Engineering

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Aim: Burn reconstruction and rehabilitation are difficult and timeconsuming processes; a burn patient must endure a long rehabilitation process to treat burn scars. The continued proliferation of scars and anxiety engender considerable difficulties for patients. A burn scar contracture is like a burned rubber band; the skin is never restored to its original flexibility. Wearing pressure garments (PGs) is uncomfortable and challenging for patients, but constant adherence is necessary. To improve adherence, precise knowledge about the advantages and disadvantages of PG therapy (PGT) is necessary. Methods: This review examined experimental studies that have applied PGT on patients with varicose veins and burns, as well as healthy human controls. The participants answered questionnaires to determine the best or "ideal" pressure. All scars were treated under a scar management program and followed up by the treating hospital and scanned by ultrasound. Scars were assessed using the Tissue Ultrasound Palpation System (TUPS), as well as the Vancouver Scar Scale (VSS) for rating scar thickness, pliability, pigmentation, and vascularity. Scar thickness and color were objectively measured using the Pliance X system and Laser Doppler Imaging (LDI). Results: In general, the application of 15-25 mmHg pressure is most commonly used in clinical practice. Minor and moderate burn patients could wear PGs in the very beginning of the recovery process. According to guidelines, closed scars should always be reevaluated 6 months after the burn to determine whether additional scar management interventions are required or whether preventive therapy can be terminated.

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“…It is shown that collagen coated electrospun PU (ccPU) results in less contraction and αSMA expression than a collagen scaffold. Also in a murine HSc model, the ccPU scaffold lead to significantly less HSc contraction than Integra . In summary, like other synthetic biomaterials, PU is a good option to improve degradation and weak mechanical properties of natural biopolymers.…”

Section: Synthetic Biomaterialsmentioning

confidence: 91%

Biomaterials for Skin Substitutes

Sheikholeslam

Wright

Jeschke

et al. 2017

Adv Healthcare Materials

165

126

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Patients with extensive burns rely on the use of tissue engineered skin due to a lack of sufficient donor tissue, but it is a challenge to identify reliable and economical scaffold materials and donor cell sources for the generation of a functional skin substitute. The current review attempts to evaluate the performance of the wide range of biomaterials available for generating skin substitutes, including both natural biopolymers and synthetic polymers, in terms of tissue response and potential for use in the operating room. Natural biopolymers display an improved cell response, while synthetic polymers provide better control over chemical composition and mechanical properties. It is suggested that not one material meets all the requirements for a skin substitute. Rather, a composite scaffold fabricated from both natural and synthetic biomaterials may allow for the generation of skin substitutes that meet all clinical requirements including a tailored wound size and type, the degree of burn, the patient age, and the available preparation technique. This review aims to be a valuable directory for researchers in the field to find the optimal material or combination of materials based on their specific application.

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Biostable electrospun microfibrous scaffolds mitigate hypertrophic scar contraction in an immune-competent murine model

Cited by 31 publications

References 56 publications

The Dynamics of the Skin’s Immune System

The Dynamics of the Skin’s Immune System

Effectiveness of Fitting Pressure Garments for Minor and Moderate Burn Patients

Biomaterials for Skin Substitutes

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