Biosynthesis Copper Nanoparticles using Blumea balsamifera Leaf Extracts: Characterization of its Antioxidant and Cytotoxicity Activities

Ginting, Binawati; Maulana, Ilham; Karnila, Ida

doi:10.1016/j.surfin.2020.100799

Cited by 38 publications

(23 citation statements)

References 48 publications

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Section: Resultssupporting

confidence: 63%

“…The obtained SPR result was in good agreement with previous results on Cu plasmonic behavior. 1 Similar results for absorption peak obtained for CuNPs were repeated at 380 nm, 42 405nm, 43 540 nm, 44 and 560 nm. 45 The reaction also involves the reduction of copper metal ions (Cu 2+ ) into CuNPs (Cu 0 ) with the active substances present in the SP fruit extract, which acts as a reducing agent and also as a stabilizing agent for the reaction.…”

Section: Uv-vis Spectroscopic Analysissupporting

confidence: 67%

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Biosynthesis and Characterization of Gold and Copper Nanoparticles from Salvadora persica Fruit Extracts and Their Biological Properties

Elhabal¹,

Elwy²,

Hassanin³

et al. 2022

IJN

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Introduction Metal nanoparticle synthesis using plant has emerged as an eco-friendly, clean, and viable strategy alternative to chemical and physical approaches. Methods The fruit extract of Salvadora persica (SP) was utilized as a reducing and stabilizing agent in the synthesis of gold (AuNPs) and copper (CuNPs) nanoparticles. Results UV–Vis spectra of the AuNPs and CuNPs showed peaks at the wavelengths of 530 nm and 440 nm, respectively. Transmission electron microscopy showed that nanoparticles exhibited a mainly spherical form, with a distribution range of 100 to 113 nm in diameter for AuNPs and of 130 to 135 nm in diameter for CuNPs. While energy-dispersive X-ray spectroscopy was able to confirm the existence of AuNPs and CuNPs. The alcoholic extract of the fruit SP was analyzed by GC-MS in order to identify whether or not it contained any active phytochemicals. Fourier-transform infrared spectra confirmed the presence capping functional biomolecules of SP on the surface of nanoparticles that acts as stabilizers. Analysis of the zeta potential revealed that NPs with high degree of stability, as demonstrated by a strong negative potential value in the range of 25.2 to 28.7 mV. Results showed that both green AuNPs and CuNPs have potential antimicrobial activity against human pathogens such gram-negative bacteria and gram-positive bacteria, with CuNPs having antimicrobial activity higher than AuNPs. In addition, AuNPs and CuNPs have promising antioxidant and anticancer properties when applied to MCF-7 and MDA-MB-231 breast cancer cells. Studies of molecular docking of SP bioactive compounds were conducted against methenyl tetrahydrofolate synthetase. Among all of them, Beta – Sitosterol was the most prominent. Conclusion These AuNPs and CuNPs are particularly appealing in a variety of applications in the pharmaceutical and medicinal industries due to their economical and environmentally friendly production.

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Section: Resultssupporting

confidence: 63%

Section: Uv-vis Spectroscopic Analysissupporting

confidence: 67%

Biosynthesis and Characterization of Gold and Copper Nanoparticles from Salvadora persica Fruit Extracts and Their Biological Properties

Elhabal¹,

Elwy²,

Hassanin³

et al. 2022

IJN

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show abstract

“…For this reason, probably for the Cu70 powder (which has the largest particle size of all tested), the highest cell survival rate is observed for the highest concentration. On the other side, the possible cytotoxicity of copper nanoparticles was reported several times [ 68 , 72 , 73 , 74 , 75 ], even if it depends on the amount and size of particles. In the case of samples of cement without additives, and cement with nanoparticles of Ni and AgCu, adhering bacteria were observed on their surface after 6 months.…”

Section: Discussionmentioning

confidence: 99%

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

et al. 2022

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Cemented arthroplasty is a common process to fix prostheses when a patient becomes older and his/her bone quality deteriorates. The applied cements are biocompatible, can transfer loads, and dampen vibrations, but do not provide antibacterial protection. The present work is aimed at the development of cement with antibacterial effectivity achieved with the implementation of nanoparticles of different metals. The powders of Ag, Cu with particles size in a range of 10–30 nm (Cu10) and 70–100 nm (Cu70), AgCu, and Ni were added to PMMA cement. Their influence on compression strength, wettability, and antibacterial properties of cement was assessed. The surface topography of samples was examined with biological and scanning electron microscopy. The mechanical properties were determined by compression tests. A contact angle was observed with a goniometer. The biological tests included an assessment of cytotoxicity (XTT test on human cells Saos-2 line) and bacteria viability exposure (6 months). The cements with Ag and Cu nanopowders were free of bacteria. For AgCu and Ni nanoparticles, the bacterial solution became denser over time and, after 6 months, the bacteria clustered into conglomerates, creating a biofilm. All metal powders in their native form in direct contact reduce the number of eukaryotic cells. Cell viability is the least limited by Ag and Cu particles of smaller size. All samples demonstrated hydrophobic nature in the wettability test. The mechanical strength was not significantly affected by the additions of metal powders. The nanometal particles incorporated in PMMA-based bone cement can introduce long-term resistance against bacteria, not resulting in any serious deterioration of compression strength.

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“…It is, therefore, important to keep track of the availability of alternative medicinal plants and herbs to conquer this challenge [ 49 ]. The discovery of new drugs that can be mastered with the use of plant extracts is a hoard of a spectrum of secondary metabolites [ 50 , 51 , 52 , 53 , 54 , 55 , 56 ].…”

Section: Microorganismsmentioning

confidence: 99%

Extraction Methods, Quantitative and Qualitative Phytochemical Screening of Medicinal Plants for Antimicrobial Textiles: A Review

Nortjie

Basitere

Moyo³

et al. 2022

Plants

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Medicinal plants are the product of natural drug discoveries and have gained traction due to their pharmacological activities. Pathogens are everywhere, and they thrive in ideal conditions depending on the nutrients, moisture, temperature, and pH that increase the growth of harmful pathogens on surfaces and textiles. Thus, antimicrobial agents and finishes may be the solution to the destruction of pathogens. This review article presents an analysis of various aspects of producing antimicrobial finishings, the microorganisms, their mechanism of attachment to natural and synthetic fibre, the effect of microbial growth, and the principle and mechanism of the microbial activity of the medicinal plants. Furthermore, the extraction methods, qualitative and quantitative phytochemical evaluations of antimicrobial efficacy, and developments of antimicrobial treated textiles using various agents are covered in this review.

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Biosynthesis Copper Nanoparticles using Blumea balsamifera Leaf Extracts: Characterization of its Antioxidant and Cytotoxicity Activities

Cited by 38 publications

References 48 publications

Biosynthesis and Characterization of Gold and Copper Nanoparticles from Salvadora persica Fruit Extracts and Their Biological Properties

Biosynthesis and Characterization of Gold and Copper Nanoparticles from Salvadora persica Fruit Extracts and Their Biological Properties

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

Extraction Methods, Quantitative and Qualitative Phytochemical Screening of Medicinal Plants for Antimicrobial Textiles: A Review

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