Biosynthesis of selenium nanoparticles and their effect on changes in urinary nanocrystallites in calcium oxalate stone formation

Abstract

Plant bio constituents have the ability to prepare nanoparticles, and usually, plant polyphenols are tested to reduce sodium selenite to selenium nanoparticles (SeNPs). In this work, we showed the biosynthesis of SeNPs using Ocimum tenuiflorum leaf extract. The as obtained SeNPs were in the size range of 15-20 nm and spherical in shape. Also, TEM microscopic images represented the aggregation of crystal structures as extracellular deposits. Moreover, scanning electron microscopy was performed to examine the chemical transition of calcium oxalate (CaC 2 O 4 ) crystal's shape and structure due to the influence of SeNPs. SeNPs inhibited the aggregation and growth of CaC 2 O 4 monohydrate crystals and hence the prepared SeNPs could have important prospects in medical and pharmaceutical applications as a potential inhibitor of CaC 2 O 4 urinary stones.

Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects

“…Similarly, many other studies have been described to explore the biosynthesis of SeNPs by using the leaf extracts of Dillenia indica, 42 Spermacoce hispida aqueous leaf extract, 19 Zingiber officinale fruit extract, 43 Carica papaya latex, 44 Citrus lemon fresh fruit extract, 45 Roselle plant extract, 46 Cinnamomum zeylanicum bark extract and Prunus amygdalus leaves extract. 47 Furthermore, the reference 48 reported spherical shaped SeNPs with a 15-20 nm size range by using Ocimum tenuiflorum leaf extract…”

Biosynthesis and antioxidation of nano-selenium using lemon juice as a reducing agent

“…Dhivya et al [33] used the water extract of cassia seeds and sodium selenite solution to synthesize amorphous spherical SeNPs with the particle sizes of 80-100 nm, which have not only inhibit bacteria and fungi but also inhibit the growth of human breast cancer cells. Liang et al [34] obtained 15-20 nm spherical SeNPs by reaction of Ocimum tenuiflorum leaf extract and sodium selenite solution. Under the influence of these small-sized nano-selenium particles, the crystal structure and shape of calcium oxalate changed, which provides a new method for the treatment of urinary calculi.…”

Green Synthesis of Selenium and Tellurium Nanoparticles: Current Trends, Biological Properties and Biomedical Applications

“…WL-Go in culture broth [182]. Liang et al used four fungal species: Aureobasidium pullulans, Mortierella humilis, Trichoderma harzianum, and Phoma glomerata, to produce SeNPs and TeNPs and provide nucleation sites with extracellular protein and polymeric substances [183]. Mosallam et al combined γ-rays and the supernatant of A. oryzae to produce SeNPs and found a strong correlation between the antioxidant capacity and both the phenolic content and SeNP yield [184].…”