Biosynthesized Iron Oxide Nanoparticles from Petroselinum crispum Leaf Extract Mitigate Lead-Acetate-Induced Anemia in Male Albino Rats: Hematological, Biochemical and Histopathological Features

El-Bahr, Sabry M.; El-Bakery, Amal M.; El‐Gazzar, Nashwa; Amin, Alaa S.; Al-Sultan, Saad I.; Alfattah, Mohammed A.; Shousha, Saad; Alhojaily, Sameer M.; Shathele, M. S.; Sabeq, Islam; Hamouda, Ahlam F.

doi:10.3390/toxics9060123

Cited by 18 publications

(20 citation statements)

References 59 publications

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“…As they are stable officers, they have an enticing future. In the present analysis, the biological efficacy of certain secondary metabolites as antioxidant, antimicrobial and antitumor was suggested for the filamentous fungi; this finding is in accordance with the observations of Chen et al (2011);El-Gazzar et al, (2021);El-Bahr et al (2021). In addition, the present investigation found that A. flavus was the most activate fungus similar with that reported with the observations of Tenguria & Khan's (2011).…”

Section: Discussionsupporting

confidence: 92%

Antioxidant, antimicrobial and antiproliferative activities of fungal metabolite produced by Aspergillus flavus on in vitro study

et al. 2022

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Regarding to the defiance came upon scientists to output natural products with potent biological activity from cheap sources and in an attempt to recover the average of antiproliferative agents, the employment of fungal metabolite in creating a cordial proper process was a prerequisite. In the present results, fungal metabolites were detected by thin layer chromatography. One fungal isolate out of ten isolates bioassayed, was showed to have the most potent antioxidant, antiproliferative and antimicrobial activity; this fungal isolate was identified as belonging to Aspergillus flavus (A. flavus). Fungal extract of A. flavus showed a high free radical scavenging activity using Diphenyl-1-picrylhydrazyl (DPPH) scavenging % with low a concentration of IC 50 and potent flavonoid content. The result of instrumental analysis using GC.Mass illustrates the presence of different potent products of A. flavus extract. In addition, A. flavus extract showed a promising antiproliferative activity. Inhibitory activity against Hepatocellular carcinoma cells was detected under these experimental conditions. This strategy can be further used to elicit new age drugs.

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Section: Discussionsupporting

confidence: 92%

Antioxidant, antimicrobial and antiproliferative activities of fungal metabolite produced by Aspergillus flavus on in vitro study

et al. 2022

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“…Fresh fruits were washed with sterile distilled water. One hundred grams of each fruit sample were mixed with distilled water at the ratio of 1:1 ( w / v ) as described previously [ 69 , 70 ], then homogenized by using a mixer (Braun combimax 700 vital, Berlin, Germany). The obtained fresh juice was then centrifuged at 15,000 rpm for 30 min at room temperature.…”

Section: Methodsmentioning

confidence: 99%

Chemical Constitution and Antimicrobial Activity of Kombucha Fermented Beverage

Al-Mohammadi¹,

Ismaiel

Ibrahim

et al. 2021

Molecules

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Kombucha is a traditional beverage of sweetened black tea fermented with a symbiotic association of acetic acid bacteria and yeasts. In this study, kombucha fermented beverage (KFB) appeared to include nine chemical groups (alcohols, acids, lactones, condensed heterocyclic compounds, antibiotics, esters, aldehydes, fatty acids, and alkaloids) of many bioactive metabolites, as elucidated by gas chromatography–mass spectrometry (GC-MS) and IR spectra. The fermented metabolic components of KFB seem collectively to act in a synergistic action giving rise to the antimicrobial activity. Four types of kombucha preparations (fermented, neutralized, heat-treated and unfermented) were demonstrated with respect to their antimicrobial activity against some pathogenic bacterial and fungal strains using agar well diffusion assay. KFB exerted the strongest antimicrobial activities when compared with neutralized and heat-treated kombucha beverages (NKB and HKB). Staphylococcus aureus ATCC6538 (S. aureus) and Escherichia coli ATCC11229 (E. coli) were the organisms most susceptible to the antimicrobial activity of kombucha beverage preparations. Finally, the KFB preparation showed remarkable inhibitory activity against S. aureus and E. coli bacteria in a brain heart infusion broth and in some Egyptian fruit juices (apple, guava, strawberry, and tomato). These data reveal that kombucha is not only a prophylactic agent, but also appears to be promising as a safe alternative biopreservative, offering protection against pathogenic bacteria and fungi.

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“…Then the sections were washed to grids made of copper or nickel. Post contrastation of the sections was determined 10 min 8% uranyl acetate and 5 min 0.7% lead citrate + 0.9% sodium citrate after drying for 15 min; sections were demonstrated in a TEM, by a JEOL 2100 TEM at 80 KV at EM Unit, Mansoura University, Egypt [61][62][63].…”

Section: Transmission Electron Microscope (Tem) Of Sec-f1mentioning

confidence: 99%

Antibacterial Peptides Produced by Alcalase from Cowpea Seed Proteins

et al. 2021

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Cowpea seed protein hydrolysates (CPH) were output from cowpea seeds applying alcalase® from Bacillus licheniformis. CPH with an elevated level of hydrolysis was fractionated by size exclusion chromatography (SEC). Both CPH and SEC-portions showed to contain antimicrobial peptides (AMPs) as they inhibited both Gram-positive bacteria, such as Listeria monocytogenes LMG10470 (L. monocytogenes), Listeria innocua. LMG11387 (L. innocua), Staphylococcus aureus ATCC25923 (S.aureus), and Streptococcus pyogenes ATCC19615 (St.pyogenes), and Gram-negative bacteria, such as Klebsiella pnemoniae ATCC43816 (K. pnemoniae), Pseudomonas aeroginosa ATCC26853 (P. aeroginosa), Escherichia coli ATCC25468) (E.coli) and Salmonella typhimurium ATCC14028 (S. typhimurium).The data exhibited that both CPH and size exclusion chromatography-fraction 1 (SEC-F1) showed high antibacterial efficiency versus almost all the assessed bacteria. The MIC of the AMPs within SEC-F1 and CPHs were (25 µg/mL) against P. aeruginosa, E.coli and St. pyogenes. However, higher MICsof approximately 100–150 µg/mL showed for both CPHs and SEC-F1 against both S. aureus and L. innocua; it was 50 µg/mL of CPH against S.aureus. The Electro-spray-ionization-mass-spectrometry (ESI-MS) of fraction (1) revealed 10 dipeptides with a molecular masses arranged from 184 Da to 364 Da and one Penta peptide with a molecular mass of approximately 659 Da inthe case of positive ions. While the negative ions showed 4 dipeptides with the molecular masses that arranged from 330 Da to 373 Da. Transmission electron microscope (TEM) demonstrated that the SEC-F1 induced changes in the bacterial cells affected. Thus, the results suggested that the hydrolysis of cowpea seed proteins by Alcalase is an uncomplicated appliance to intensify its antibacterial efficiency.

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Biosynthesized Iron Oxide Nanoparticles from Petroselinum crispum Leaf Extract Mitigate Lead-Acetate-Induced Anemia in Male Albino Rats: Hematological, Biochemical and Histopathological Features

Cited by 18 publications

References 59 publications

Antioxidant, antimicrobial and antiproliferative activities of fungal metabolite produced by Aspergillus flavus on in vitro study

Antioxidant, antimicrobial and antiproliferative activities of fungal metabolite produced by Aspergillus flavus on in vitro study

Chemical Constitution and Antimicrobial Activity of Kombucha Fermented Beverage

Antibacterial Peptides Produced by Alcalase from Cowpea Seed Proteins

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