Biosynthesized zinc oxide nanoparticles (ZnO NPs) using actinomycetes enhance the anti-bacterial efficacy against K. Pneumoniae

Rajivgandhi, Govindan; Gnanamangai, Balasubramanian Mythili; Prabha, Thirumoorthy Heela; Poornima, S.; Maruthupandy, Muthuchamy; Alharbi, Naiyf S.; Kadaikunnan, Shine; Li, Wenjun

doi:10.1016/j.jksus.2021.101731

Cited by 40 publications

(24 citation statements)

References 35 publications

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“…This white color is common for ZnO NPs, which are equivalent to earlier biosynthetic ZnO NPs generated from other bioactive materials and have a visible range of 300-400 nm 51 . The real highest absorption peak of synthetic ZnO NPs that verified the generation of ZnO NPs previously ranged from 275 to 365 nm, depending on the biosynthesis technique and reduction reaction (reductant and precursor) utilized 20,33,[52][53][54][55] . For our biosynthetic ZnO NPs, the maximum UV-visible absorption peak was found at 320 nm.…”

Section: Resultsmentioning

confidence: 97%

“…In recent years, this method has also proven to be useful for the production of nanomaterials with various morphologies. It has recently been demonstrated that processing parameters in the biosynthetic reaction, such as temperature, pH, mixing ratio, incubation period, and aeration, can enhance the biosynthesis of NPs with different morphologies 20,48 . Our study focuses on the optimization of the ZnO NPs biosynthetic reaction and the microbial growth culturing process using a safe microbial source, such as endophytic Streptomyces albus strain E56.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the availability of these functional chemical groups in cell-free extract, which regulate the reduction of Zn ions to ZnO NPs, could explain the generation of ZnO NPs. Based on the results of a recent study 20 , Eq. ( 1) provides a hypothesized biological synthesis pathway for ZnO NPs using mixed cell-free extract as a reductant/capping agent and NaOH to control the biosynthesis reaction pH that was mixed with ZnSO 4 .7H 2 O as a precursor.…”

Section: Resultsmentioning

confidence: 99%

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Scaling-up strategies for controllable biosynthetic ZnO NPs using cell free-extract of endophytic Streptomyces albus: characterization, statistical optimization, and biomedical activities evaluation

EL-Moslamy

Elnouby

Rezk

et al. 2023

Sci Rep

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In this study, we identified a suitable precursor and good cellular compartmentalization for enhancing bioactive metabolites to produce biosynthetic zinc oxide nanoparticles (ZnO NPs). An effective medium for cultivating endophytic Streptomycesalbus strain E56 was selected using several optimized approaches in order to maximize the yield of biosynthetic ZnO NPs. The highest biosynthetic ZnO NPs yield (4.63 g/L) was obtained when pipetting the mixed cell-free fractions with 100 mM of zinc sulfate as a precursor. The generation of biosynthetic ZnO NPs was quickly verified using a colored solution (white color) and UV–Visible spectroscopy (maximum peak, at 320 nm). On a small scale, the Taguchi method was applied to improve the culture medium for culturing the strain E56. As a result, its cell-dry weight was 3.85 times that of the control condition. And then the biosynthesis of ZnO NPs (7.59 g/L) was increased by 1.6 times. Furthermore, by using the Plackett–Burman design to improve the utilized biogenesis pathway, the biosynthesis of ZnO NPs (18.76 g/L) was increased by 4.3 times. To find the best growth production line, we used batch and fed batch fermentation modes to gradually scale up biomass output. All kinetics of studied cell growth were evaluated during fed-batch fermentation as follows: biomass yield was 271.45 g/L, yield coefficient was 94.25 g/g, and ZnO NPs yield was 345.32 g/L. In vitro, the effects of various dosages of the controllable biosynthetic ZnO NPs as antimicrobial and anticancer agents were also investigated. The treatments with controllable biosynthetic ZnO NPs had a significant impact on all the examined multidrug-resistant human pathogens as well as cancer cells.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Scaling-up strategies for controllable biosynthetic ZnO NPs using cell free-extract of endophytic Streptomyces albus: characterization, statistical optimization, and biomedical activities evaluation

EL-Moslamy

Elnouby

Rezk

et al. 2023

Sci Rep

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“…In recent research, Streptomyces spp. were used for the synthesis of white-colored and hexagonal ZnO nanoparticles with biomedical applications [ 59 ]. This research showed that only three strains from five isolated samples were effective for the synthesis of ZnO nanoparticles.…”

Section: Green Synthesis Of Nanomaterialsmentioning

confidence: 99%

Plant and Microbial Approaches as Green Methods for the Synthesis of Nanomaterials: Synthesis, Applications, and Future Perspectives

et al. 2023

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The unique biological and physicochemical characteristics of biogenic (green-synthesized) nanomaterials (NMs) have attracted significant interest in different fields, with applications in the agrochemical, food, medication delivery, cosmetics, cellular imaging, and biomedical industries. To synthesize biogenic nanomaterials, green synthesis techniques use microorganisms, plant extracts, or proteins as bio-capping and bio-reducing agents and their role as bio-nanofactories for material synthesis at the nanoscale size. Green chemistry is environmentally benign, biocompatible, nontoxic, and economically effective. By taking into account the findings from recent investigations, we shed light on the most recent developments in the green synthesis of nanomaterials using different types of microbes and plants. Additionally, we cover different applications of green-synthesized nanomaterials in the food and textile industries, water treatment, and biomedical applications. Furthermore, we discuss the future perspectives of the green synthesis of nanomaterials to advance their production and applications.

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“…According to studies, incorporating TiO 2 and ZnO nanoparticles into natural polymer greatly improved wound healing characteristics [ 13 , 14 ]. ZnO nanoparticles also exhibit unique characteristics such as great biocompatibility, low toxicity [ 15 ], strong photocatalytic activity [ 16 ], and high antibacterial properties [ 17 ], attracting our interest for usage in wound healing. Aside from inorganic ZnO nanoparticles, organic materials based on carbon component embedded in polymer are well-known methods for improving the antimicrobial activity [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Properties and Antibacterial Activity of Gellan Gum Incorporating Zinc Oxide/Carbon Nanotubes Bionanocomposite Film for Wound Healing

Liu

Ismail

Yusoff

et al. 2022

Bioinorganic Chemistry and Applications

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Wound healing dressing based on a natural polymer of gellan gum incorporating zinc oxide nanoparticles and multiwall carbon nanotubes (GG/ZnONP + MWCNT) bionanocomposite film was fabricated via the solution casting method. The physicochemical properties of the film were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR), and scanning electron microscopy (SEM). Moreover, the antibacterial properties of the bionanocomposite film were investigated for wound healing applications. The characterization results confirmed the reinforcement of the gellan gum (GG) matrix with zinc oxide nanoparticles (ZnONP) and multiwall carbon nanotubes (MWCNT), as an amorphous GG/ZnONP + MWCNT bionanocomposite film was obtained. SEM morphological analysis shows that the addition of ZnONP and MWCNT nanofillers changed the film microstructure into a sponge-like structure that is more suitable for fluid uptake and thus more useful for wound healing. The GG/ZnONP + MWCNT bionanocomposite film demonstrated good antibacterial activity against all strains tested. Furthermore, macroscopic analysis shows that the wound treated with GG/ZnONP + MWCNT bionanocomposite film recovered completely (100%) in 14 days, compared to pure GG film (90.76%) and negative control (77.40%). As a result, the GG/ZnONP + MWCNT bionanocomposite film could be a promising wound dressing material.

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Biosynthesized zinc oxide nanoparticles (ZnO NPs) using actinomycetes enhance the anti-bacterial efficacy against K. Pneumoniae

Cited by 40 publications

References 35 publications

Scaling-up strategies for controllable biosynthetic ZnO NPs using cell free-extract of endophytic Streptomyces albus: characterization, statistical optimization, and biomedical activities evaluation

Scaling-up strategies for controllable biosynthetic ZnO NPs using cell free-extract of endophytic Streptomyces albus: characterization, statistical optimization, and biomedical activities evaluation

Plant and Microbial Approaches as Green Methods for the Synthesis of Nanomaterials: Synthesis, Applications, and Future Perspectives

Physicochemical Properties and Antibacterial Activity of Gellan Gum Incorporating Zinc Oxide/Carbon Nanotubes Bionanocomposite Film for Wound Healing

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