Biotin Production by Bifidobacteria.

Noda, Hiroko; Akasaka, Noriko; Ohsugi, Masahiro

doi:10.3177/jnsv.40.181

Cited by 41 publications

(17 citation statements)

References 10 publications

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“…For instance, the gut commensals Bifidobacterium and Lactobacillus can synthesize the B9 vitamin folate (Noda et al 1994;Pompei et al 2007;Strozzi and Mogna 2008;Kleerebezem and Vaughan 2009), which was shown to have a critical role in the maintenance of Treg cells in the small intestine (Kunisawa et al 2012). Vitamin B12 deficiency results in a decreased number of lymphocytes and suppressed NK cell activity (Tamura et al 1999).…”

Section: Retinoic Acid (Ra)mentioning

confidence: 99%

Metabolites: messengers between the microbiota and the immune system

2016

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The mammalian intestine harbors one of the largest microbial densities on Earth, necessitating the implementation of control mechanisms by which the host evaluates the state of microbial colonization and reacts to deviations from homeostasis. While microbial recognition by the innate immune system has been firmly established as an efficient means by which the host evaluates microbial presence, recent work has uncovered a central role for bacterial metabolites in the orchestration of the host immune response. In this review, we highlight examples of how microbiota-modulated metabolites control the development, differentiation, and activity of the immune system and classify them into functional categories that illustrate the spectrum of ways by which microbial metabolites influence host physiology. A comprehensive understanding of how microbiota-derived metabolites shape the human immune system is critical for the rational design of therapies for microbiota-driven diseases.The mammalian intestine harbors a dense and complex microbial community, termed the microbiota. The commensal microbiome and, in particular, the dense and diverse microbial community inhabiting the gastrointestinal tract play a pivotal role in the maintenance of organismal homeostasis and stable physiology. Research over the last decade has highlighted the concept that the eukaryotic host and its microbiota, rather than existing in isolation, compose a complex meta-organism termed the "holobiont," jointly regulating multiple aspects of mammalian physiology, including immune system development, metabolism, and nervous system function (Sommer and Backhed 2013). The interaction between the microbiota and the host is most prominent at mucosal surfaces, which provide an interface between the mostly microbe-free host, the microbiota, and the environment. At the same time, the presence of the microbial community within the eukaryotic host necessitates the development of a sophisticated immune system that controls and maintains a beneficial symbiosis of the holobiont through the continuous communication between the microbiome and the host.

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Section: Retinoic Acid (Ra)mentioning

confidence: 99%

Metabolites: messengers between the microbiota and the immune system

2016

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“…Pollen is a rich source of Vitamin B but lactobacilli and bifidobacteria could produce at least Vitamin B7, B11 and B12 (Noda et al, 1994;Crittenden et al, 2003;Pompei et al, 2007;Santos et al, 2008) and…”

Section: Sequence Lengths (And % Similarity) **mentioning

confidence: 99%

The lactic acid bacteria involved in the production of bee pollen and bee bread

Vásquez

Olofsson

2009

Journal of Apicultural Research

236

179

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Recently a large flora of lactic acid bacteria (LAB) was identified in the honey stomach of the honey bee Apis mellifera. In this study, the presence of this flora in bee pollen and bee bread was investigated. Pollen was collected from the legs of honey bees, and both two week old and two month old bee bread were also obtained for the study. Bacterial isolates cultivated from these bee products were identified using 16S rRNA gene analyzes. The majority of the honey stomach LAB flora was recovered in a viable state from both the pollen and the two week old bee bread, but not from the two month old bee bread. It is demonstrated for the first time that bee bread is probably fermented by the honey stomach LAB flora that has been added to the pollen via regurgitated nectar from the honey stomach. This discovery helps to explain how honey bees standardize the production of bee bread and how it is stored. The presence of the honey stomach LAB and its antimicrobial substances in bee bread also suggests a possible role in the defence against honey bee diseases since the bee bread is consumed by both the larvae and the adult bees. Bacterias del ácido láctico implicadas en la producción polen de abeja y pan de abeja ResumenRecientemente una gran flora de bacterias del ácido láctico (BAL) fue identificada en el estómago de la abeja de la miel Apis mellifera. En este estudio se ha investigado la presencia de esta flora en el polen de las abejas y en el pan de abejas. El polen se obtuvo de las patas de las abejas, y el pan de abejas fue también recolectado a las dos semanas y a los dos meses de edad para el estudio. Cepas de bacterias cultivadas a partir de estos productos de la abeja se identificaron mediante análisis del gen ribosomal 16S. La mayoría de la flora estomacal BAL fue recuperada en un estado viable, tanto en el polen como en el pan de abejas a las dos semanas de edad, pero no en el pan de abejas a los dos meses de edad. Por primera vez se demuestra que el pan de abejas es probablemente fermentado por la flora BAL del estómago de la miel que se añade al polen a partir de néctar regurgitado del estómago. Este descubrimiento ayuda a explicar cómo las abejas regulan la producción de pan de abejas y la forma en que se almacena. La presencia en el estómago de BAL y de sustancias antimicrobianas en el pan de abejas también sugiere una posible función en la defensa contra las enfermedades de la abeja de la miel, ya que el pan de abejas es consumido por adultos y larvas de abejas.

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“…Their physiological activity is thought to exert a range of beneficial effects on host health, such as protection against potentially pathogenic bacteria (Bernet et al 1993;Gibson and Wang 1994;Fujiwara et al 1999), reduction of serum cholesterol levels (Tahri et al 1995), vitamin production (Noda et al 1994) and enhancement of immune response (Kado-Oka et al 1991).…”

Section: Introductionmentioning

confidence: 98%

Conditions affecting cell surface properties of human intestinal bifidobacteria

Canzi

Guglielmetti

Mora

et al. 2005

Antonie Van Leeuwenhoek

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The cell surface properties of human intestinal bifidobacteria have been characterized for 30 strains isolated from a fecal sample. Strain identification to the species level was obtained by restriction analysis of the amplified 16S rRNA gene and confirmed by DNA/DNA reassociation experiments. The isolates were grouped in four genetically homogeneous clusters whose members belonged to Bifidobacterium bifidum, Bifidobacterium adolescentis, Bifidobacterium longum and Bifidobacterium pseudocatenulatum species. Cell surface properties of Bifidobacterium strains were evaluated by determining the level of hydrophobicity, adhesion to hydrocarbons and contact angle measurements, and their autoaggregation ability. The results showed high and homogeneous level of hydrophobicity in all tested strains when contact angle measurements values were considered. On the contrary, autoaggregation assays and bacterial adhesion to hydrocarbons detected interesting differences in cell surface properties among the tested Bifidobacterium strains. The highest levels of autoaggregation, detected in B. bifidum and B. adolescentis strains, were strictly dependent on the pH of the medium. Moreover, protease treatment experiments suggested that proteins had a key role in the autoaggregating ability of B. bifidum and B. adolescentis strains.

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Biotin Production by Bifidobacteria.

Cited by 41 publications

References 10 publications

Metabolites: messengers between the microbiota and the immune system

Metabolites: messengers between the microbiota and the immune system

The lactic acid bacteria involved in the production of bee pollen and bee bread

Conditions affecting cell surface properties of human intestinal bifidobacteria

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