The paper considers respiratory support strategies in neonatal intensive care practice. The paper describes the impact of noninvasive mechanical ventilation (NIMV) on oxygenation in premature babies. In order to improve the differentiated choice of targeted two-phase NIMV as a starting respiratory support, the authors have made a follow-up assessment of respiratory tactics and perinatal outcomes in premature babies of small gestational age. The data of the follow-up of 90 extremely low-birth weight babies, which was performed at 6 months of adjusted age, were compared with the comprehensive perinatal assessment criteria and with clinical, laboratory, and instrumental data obtained in the early neonatal period.