Biplane transrectal ultrasonography plus ultrasonic elastosonography and contrast-enhanced ultrasonography in T staging of rectal cancer

Feng, Yanru; Peng, Chanjuan; Zhu, Yuan; Liu, Lu-ying

doi:10.1186/s12885-020-07369-0

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…If necessary, contrast-enhanced ultrasonography can be performed to facilitate T staging. 13 In addition, there may be inflammatory reactions at the edge of the tumor, and the ultrasound image often is not clear enough to distinguish a tumor from surrounding tissue with inflammation, so the boundary of the lesion displayed on the ultrasound image may be beyond the actual boundary of the tumor or the depth of invasion. At this time, the ultrasonography results are overestimated compared with the pathological results.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, conventional transabdominal or transvaginal ultrasonography has a low T-staging accuracy for upper RC. If necessary, contrast-enhanced ultrasonography can be performed to facilitate T staging 13 . In addition, there may be inflammatory reactions at the edge of the tumor, and the ultrasound image often is not clear enough to distinguish a tumor from surrounding tissue with inflammation, so the boundary of the lesion displayed on the ultrasound image may be beyond the actual boundary of the tumor or the depth of invasion.…”

Section: Discussionmentioning

confidence: 99%

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The Value of Transanal Normal Saline Infusion–Assisted Multipath Ultrasonography in the Diagnosis of T1/T2 Rectal Cancer

Wu,

Wei,

Chen

et al. 2023

Ultrasound Quarterly

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This study aims to assess the application value of transanal normal saline infusion–assisted multipath ultrasonography (TNSI-MU) in the diagnosis of T1/T2 rectal cancer (RC). All patients first received single-path 360-degree transrectal ultrasonography and then received 360-degree transrectal ultrasonography, transabdominal ultrasonography, or transvaginal ultrasonography after TNSI to determine the T stage. With surgical pathology as the criterion standard, the detection rates of T1/T2 RC lesions and the T-staging results of single-path 360-degree transrectal ultrasonography, TNSI-MU, and contrast-enhanced magnetic resonance imaging (MRI) were compared and analyzed. T1/T2 RC was surgically and pathologically confirmed in 52 patients. Single-path 360-degree transrectal ultrasonography had a lesion detection rate of 57.69% (30/52) and a T-staging accuracy of 80.0% (24/30), the sensitivity was 57.69%, and the specificity was 88.46%. Transanal normal saline infusion–assisted multipath ultrasonography had a lesion detection rate of 100%, and its T-staging accuracy was 84.62% (44/52), the sensitivity was 100%, and the specificity was 88.61%. Transanal normal saline infusion–assisted multipath ultrasonography had a significantly higher detection rate of T1/T2 RC lesions than single-path 360-degree transrectal ultrasonography (P < 0.001), but the 2 methods had similar T-staging accuracy for T1/T2 RC (χ2 = 0.286, P = 0.593). Contrast-enhanced MRI had a lesion detection rate of 100% and a T-staging accuracy of 40.38% (21/52), the sensitivity was 98.07%, and the specificity was 61.54%. Transanal normal saline infusion–assisted multipath ultrasonography had significantly higher diagnostic accuracy than contrast-enhanced MRI for T staging of T1/T2 RC (P < 0.001), and the diagnostic results of the 2 methods were not consistent (κ = 0.151). Transanal normal saline infusion–assisted multipath ultrasonography outperformed single-path 360-degree transrectal ultrasonography in the detection rate of T1/T2 RC lesions and contrast-enhanced MRI in the staging accuracy for T1/T2 RC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Value of Transanal Normal Saline Infusion–Assisted Multipath Ultrasonography in the Diagnosis of T1/T2 Rectal Cancer

Wu,

Wei,

Chen

et al. 2023

Ultrasound Quarterly

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“…With advances in imaging technology, ultrasonography can be used to accurately diagnose diseases. Transrectal ultrasonography (TRUS) is widely used to diagnose rectal lesions ( 4 - 7 ) and is applied in the T staging of rectal cancer for accurate identification ( 8 ). Both TRUS and magnetic resonance imaging (MRI) are the common and preferred imaging examination methods in the diagnosis of rectal cancer ( 9 - 11 ).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic advantages of transrectal ultrasound with gastrointestinal agent instillation for rectal adenoma and early-stage rectal cancer: comparison of conventional transrectal ultrasound techniques

Li,

Huang,

Liu

et al. 2024

Quant Imaging Med Surg

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Background Despite being a major focus of medical research for decades, rectal cancer remains a major threat to human health. This study aimed to compare and analyze the diagnostic value of transrectal ultrasonography (TRUS) for rectal adenoma and early-stage rectal cancer before and after gastrointestinal agent instillation. Methods In this prospective study, patients diagnosed with rectal adenomas and early-stage rectal cancer by ultrasound were randomly selected for inclusion. All patients underwent ultrasound examination at the Outpatient Department of the First Affiliated Hospital of China Medical University and underwent surgical treatment at the First Affiliated Hospital of China Medical University. Patients with a lesion located 13 cm or more from the edge of the anus, or history of surgery, and a history of radiation and chemotherapy were excluded. A gastrointestinal agent was directly instilled into the rectal cavity during conventional TRUS to compare and analyze the display of rectal lesions before and after such instillation and to evaluate the infiltration depth of rectal lesions. These findings were compared to the pathological findings to determine the diagnostic efficacy. Results Both the conventional TRUS and TRUS with gastrointestinal agent instillation were able to show the rectal wall structure and rectal lesions; the detection rate of rectal lesions of the former was 75.0%, and that of the latter was 97.1% (P<0.001). Of the 27 rectal adenomas, conventional TRUS detected 10, and TRUS with gastrointestinal agent instillation detected 25 lesions. The accuracy [90.54%; 95% confidence interval (CI): 81.48–96.11%; P=1.05E−08], specificity (87.88%; 95% CI: 71.80–96.60%; P=1.09E−05), and sensitivity (92.68%; 95% CI: 80.08–98.47%; P=1.05E−08) of TRUS in diagnosing early-stage rectal cancer were consistent with the pathological findings (P<0.001). The accuracy (95.95%, 95% CI: 88.61–99.16%; P=3.82E−11), specificity (93.94%, 95% CI: 79.77–99.26%; P=1.31E−07), and sensitivity (97.56%, 95% CI: 87.15–99.94%; P=3.82E−11) of TRUS after gastrointestinal agent infusion in diagnosing early-stage rectal cancer were consistent with the pathological findings (P<0.001). The specificity (87.88%; 95% CI: 71.80–96.60%; P=1.09E−05) of TRUS in diagnosing rectal adenomas was consistent with the pathological finding (P<0.001), but the accuracy (65%; 95% CI: 51.60–76.87%; P=0.25) and sensitivity (37.04%, 95% CI: 19.40–57.63%; P=0.25) were not (P>0.05). Meanwhile, the accuracy (93.33%; 95% CI: 83.80–98.15%; P=5.65E−06), specificity (93.94; 95% CI: 79.77–99.26%; P=1.31E−07), and sensitivity (92.59%; 95% CI: 75.71–99.09%; P=5.65E−06) of TRUS after gastrointestinal agent infusion in diagnosing rectal adenomas were consistent with the pathological findings (P<0.001). Conclusions TRUS with gastrointestinal agent instillation had significantly improved accuracy in diagnosing early-stage rectal cancer and detecting intrarectal...

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“…Angiogenesis provides oxygen to the tumor, excretes metabolic waste, and supplies many branched blood vessels, which is essential for tumor invasion and metastasis [ 4 ]. In recent years, with the development of ultrasonic medicine, contrast-enhanced ultrasound (CEUS) has become a reliable method to quantitatively study the process of tumor angiogenesis [ 5 ] However, there is little information regarding the application of microbubble contrast agents in intestinal diseases, especially the time-intensity curve (TIC) of transrectal ultrasound (TRUS) in the quantitative assessment of rectal tumor angiogenesis [ 6 , 7 ]. Therefore, this proposed research quantitatively assessed the microcirculatory perfusion status by ultrasonography to predict rectal cancer lymph node metastasis.…”

Section: Introductionmentioning

confidence: 99%

Construction of machine learning models based on transrectal ultrasound combined with contrast-enhanced ultrasound to predict preoperative regional lymph node metastasis of rectal cancer

Huang,

Yang,

Qin

et al. 2024

Heliyon

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Biplane transrectal ultrasonography plus ultrasonic elastosonography and contrast-enhanced ultrasonography in T staging of rectal cancer

Cited by 6 publications

References 19 publications

The Value of Transanal Normal Saline Infusion–Assisted Multipath Ultrasonography in the Diagnosis of T1/T2 Rectal Cancer

The Value of Transanal Normal Saline Infusion–Assisted Multipath Ultrasonography in the Diagnosis of T1/T2 Rectal Cancer

Diagnostic advantages of transrectal ultrasound with gastrointestinal agent instillation for rectal adenoma and early-stage rectal cancer: comparison of conventional transrectal ultrasound techniques

Construction of machine learning models based on transrectal ultrasound combined with contrast-enhanced ultrasound to predict preoperative regional lymph node metastasis of rectal cancer

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