Bipolar disorder associated with rheumatoid arthritis: A case-control study

Farhi, Adir; Cohen, Arnon D; Shovman, Ora; Comaneshter, Doron; Amital, Howard; Amital, Daniela

doi:10.1016/j.jad.2015.09.058

Cited by 35 publications

(31 citation statements)

References 14 publications

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“…Although the prevalence of anxiety disorders is reportedly increased in RA , we could not identify prior studies reporting the incidence of anxiety disorders. Our findings regarding the increased incidence of bipolar disorder in RA are consistent with 1 previous study which evaluated the association of RA and bipolar disorder . In that study of 2,570 individuals with RA from Taiwan and 2,570 individuals without RA, matched on age, sex, comorbidities, and date of enrollment in the national health insurance plan, RA was associated with a 2‐fold increased incidence of bipolar disorder .…”

Section: Discussionsupporting

confidence: 91%

Increased Burden of Psychiatric Disorders in Rheumatoid Arthritis

Marrie

Hitchon

Walld

et al. 2018

Arthritis Care & Research

121

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ObjectiveWe estimated the incidence and prevalence of depression, anxiety disorder, bipolar disorder, and schizophrenia in a population‐based cohort with rheumatoid arthritis (RA) as compared to an age‐, sex‐, and geographically matched cohort without RA.MethodsUsing population‐based administrative health data from Manitoba, Canada, we identified persons with incident RA between 1989 and 2012, and a cohort from the general population matched 5:1 on year of birth, sex, and region of residence. We applied validated algorithms for depression, anxiety disorder, bipolar disorder, and schizophrenia to determine the annual incidence of these conditions after the diagnosis of RA, and their lifetime and annual period prevalence. We compared findings between cohorts using negative binomial regression models.ResultsWe identified 10,206 incident cases of RA and 50,960 matched individuals. After adjustment for age, sex, socioeconomic status, region of residence, number of physician visits, and year, the incidence of depression was higher in the RA cohort over the study period (incidence rate ratio [IRR] 1.46 [95% confidence interval (95% CI) 1.35–1.58]), as was the incidence of anxiety disorder (IRR 1.24 [95% CI 1.15–1.34]) and bipolar disorder (IRR 1.21 [95% CI 1.00–1.47]). The incidence of schizophrenia did not differ between groups (IRR 0.96 [95% CI 0.61–1.50]). Incidence rates of psychiatric disorders declined minimally over time. The lifetime and annual period prevalence of depression and anxiety disorder were also higher in the RA than in the matched cohort over the study period.ConclusionThe incidence and prevalence of depression, anxiety disorder, and bipolar disorder are elevated in the RA population as compared to a matched population.

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Section: Discussionsupporting

confidence: 91%

Increased Burden of Psychiatric Disorders in Rheumatoid Arthritis

Marrie

Hitchon

Walld

et al. 2018

Arthritis Care & Research

121

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“…However, a systematic review found that psychological factors were the most frequently reported cause for the association between SLE and depression . The association between an autoimmune disease and a neuropsychiatric disease is also found in other autoimmune diseases besides LE, for example in patients with rheumatoid arthritis …”

Section: Discussionmentioning

confidence: 99%

“…18 The association between an autoimmune disease and a neuropsychiatric disease is also found in other autoimmune diseases besides LE, for example in patients with rheumatoid arthritis. 21,22 In general, patients with dermatological diseases have a reduced quality of life and have an increased prevalence of psychiatric morbidity including depression. 2 This is shown in previous studies where an association between depression and atopic dermatitis, 23 rosacea 24 and psoriasis 25 is found, which is in line with our findings regarding CLE and the increased risk of depression and antidepressant use.…”

Section: Discussionmentioning

confidence: 99%

Increased risk of depression in patients with cutaneous lupus erythematosus and systemic lupus erythematosus: a Danish nationwide cohort study

et al. 2018

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“…The CHS perform the process of validation by logistic checks (such as comparing diagnoses from various sources) and by direct validation of the diagnoses by the treating physicians of each patient. The validity of the diagnoses in the registry was shown to be of high standard in previous studies we completed . We did not omit patients who developed different comorbidities from the analysis.…”

Section: Methodsmentioning

confidence: 99%

“…The validity of the diagnoses in the registry was shown to be of high standard in previous studies we completed. [16][17][18][19][20][21][22] We did not omit patients who developed different comorbidities from the analysis.…”

Section: Methodsmentioning

confidence: 99%