Bipolar Spectrum Disorder May Be Associated With Family History of Diseases

Kesebir, Sermin; Koc, Merve Iris; Yosmaoglu, Ahmet

doi:10.14740/jocmr4143

Cited by 6 publications

(13 citation statements)

References 14 publications

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“…Previous studies evaluating associations between bipolar disorder and prostate cancer focused on co‐occurrence of categorical entities. Increased incidence of bipolar disorder has been identified among patients with prostate cancer, 11 as well as this neoplasm is more common among bipolar disorder individuals 9 . Our study shows that prostate cancer patients present higher rates of bipolar spectrum symptoms, which may constitute subclinical manifestation of overlapping genetic underpinnings of both diseases.…”

Section: Discussionmentioning

confidence: 53%

“…Increased incidence of bipolar disorder has been identified among patients with prostate cancer, 11 as well as this neoplasm is more common among bipolar disorder individuals. 9 Our study shows that prostate cancer patients present higher rates of bipolar spectrum symptoms, which may constitute subclinical manifestation of overlapping genetic underpinnings of both diseases. Bipolarity traits in this clinical group may have an impact on the course and the treatment of depression among prostate cancer patients.…”

Section: Discussionmentioning

confidence: 70%

“…Studies point out that patients with bipolar disorder have a higher risk of developing cancer. It has been shown that prostate cancer, acute and chronic leukaemias, breast, pancreas, and other tumors of the digestive system, such as proliferative and carcinoid neoplasms, are more common in bipolar disorder (BD) than in healthy individuals 8,9 . Also, diagnosis of cancer may be associated with a higher probability of coexisting bipolar disorder.…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that prostate cancer, acute and chronic leukaemias, breast, pancreas, and other tumors of the digestive system, such as proliferative and carcinoid neoplasms, are more common in bipolar disorder (BD) than in healthy individuals. 8,9 Also, diagnosis of cancer may be associated with a higher probability of coexisting bipolar disorder. Among these neoplasms, prostate cancer, the most common cancer in men, is of particular interest.…”

Section: Introductionmentioning

confidence: 99%

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Bipolar spectrum in prostate cancer patients and its role in stress related symptoms

et al. 2023

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Background: Studies show significant co-occurrence of bipolar disorder and prostate cancer, as well as the presence of shared genes associated with both diseases.Our aim was to evaluate whether prostate cancer patients present bipolar spectrum symptoms and to establish their possible associations with stress related symptoms during diagnosis and the course of the cancer therapy.Methods: 200 participants were enrolled to this study: 100 prostate cancer patients and 100 healthy males. Bipolar spectrum symptoms were measured with the use of Mood Disorder Questionnaire and Hypomania Checklist-32 (HCL-32). Stress related symptoms were rated with The Impact of Events Scale-Revised (IES-R), Perceived Stress Scale-10 (PSS-10) and Generalised Self-Efficacy Scale (GSES). Results:In comparison to healthy controls group, prostate cancer patients have shown higher HCL-32 scores. Mood Disorder Questionnaire measures were associated with more severe stress related to prostate cancer diagnosis and treatment reflected by higher scores of IES-R and its subscales (Avoidance, Intrusions and Hyperarousal). Mood Disorder Questionnaire, HCL-32, PSS-10, IES-R and GSES measures were not associated with clinical characteristics of prostate cancer severity.Limitations: Cross-sectional study model precluded identification of causal relationship among variables. Bipolar spectrum symptoms and stress related measures were based on auto-questionnaires. Conclusions:To our best knowledge, this is the first study evaluating bipolar spectrum symptoms in prostate cancer patients. We have shown that this clinical group presents increased bipolarity traits compared to healthy individuals. Moreover, bipolar spectrum symptoms were associated with more severe stress related to the prostate cancer diagnosis and its treatment, reflected in avoidance, hyperarousal, and intrusions.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bipolar spectrum in prostate cancer patients and its role in stress related symptoms

et al. 2023

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“…Because the mind uses the brain as an interface. For this reason, psychiatric disorders and physical diseases occur through similar mechanisms and processes 13,14 .…”

Section: Dıscussıonmentioning

confidence: 99%

The Two new biomarkers: Bipolar Self, Bipolar EEG

Kesebir

2024

MRAJ

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Background: Although self theory was initially interested in narcissism, it began to explain depression over time. In our previous study, we showed that there was a relationship between self-inventory and mood disorder questionnaire scores in healthy individuals. Self-inventory defensive subscale scores of cases diagnosed with bipolar disorder were higher than healthy individuals. The aim of this study is to investigate whether there is a relationship between self-inventory scores and EEG spectral power densities in bipolar patients. Methods: For this purpose, 50 cases diagnosed with bipolar disorder according to DSM-V were evaluated consecutively during their regular check-ups in our outpatient clinic. Subjects who gave voluntary consent to participate in the study were required to be in remission period for at least 8 weeks. Self Inventory and EEG applied. Results: A relationship was found between compensatory grandiose self and FP1 alpha activity, and between defensive grandiose self and F3, Pz, T4, T5 beta activity (Table-1). There is a relationship between compensatory idealized parent image and FP1 delta ve theta, F7 theta, and between defensive idealized parent image and O1, O2 theta T6 beta activity. Conclusion: According to our results, self-pathology and bipolar disorder overlap electrophysiologically. This suggests that more investigation should be done on the structural origin of mood disorders, in other words, whether the predisposition is a trait or not.

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Reclassification of Mood Disorders with Comorbid Medical Diseases based on Sinai-Ruelle-Bowen/ SRB Entropy Measures

Kesebir,

Demirer

2023

MRAJ

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Background: Current classification systems ignore the family histories of patients and psychiatric and medical comorbidity. Methods: We study a new approach of applying spectral clustering to determine distinct bipolar disorder subtypes, which is data whose clusters are of various sizes and densities. We discovered clusters by processing a SRB (Sinai-Ruelle-Bowen) similarity matrix that reflects the proximity of Von Bertalanffy’s functions fitted to phase growth dynamics of EEG (electroencephalography) within a new pipeline architecture. For this purpose, 109 patients diagnosed with bipolar disorder according to DSM-V (Diagnostic and Statistical Manual of Mental Disorders, fifth edition) were evaluated in remission period cross-sectionally. Results: We found three distinct bipolar disorder subtypes with the p-values < 0.001. We exhibit mixing sub-shifts of EEG phase gradients such that there are chaotic phase transitions but higher order phase gradients in a cone basin is always strictly convex. More surprisingly, we show that the SRB entropy measures on some time interval although there exist several equilibrium states each corresponds to equilibrium state. Conclusion: It seems subtypes of the bipolar spectrum were shaped according to seasonality, comorbidity for anxiety disorder and presence of psychotic symptom.

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Bipolar Spectrum Disorder May Be Associated With Family History of Diseases

Cited by 6 publications

References 14 publications

Bipolar spectrum in prostate cancer patients and its role in stress related symptoms

Bipolar spectrum in prostate cancer patients and its role in stress related symptoms

The Two new biomarkers: Bipolar Self, Bipolar EEG

Reclassification of Mood Disorders with Comorbid Medical Diseases based on Sinai-Ruelle-Bowen/ SRB Entropy Measures

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