BIRC5 promoter SNPs do not affect nuclear survivin expression and survival of malignant pleural mesothelioma patients

Hmeljak, Julija; Erčulj, Nina; Dolžan, Vita; Kern, Izidor; Cör, Andrej

doi:10.1007/s00432-011-1030-0

Cited by 19 publications

(15 citation statements)

References 46 publications

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“…Gordon et al detected 76 % of survivin positive malignant pleural mesotheliomas (Gordon et al, 2007), which is in concordance with the 77 % of survivin positive malignant pleural mesotheliomas detected by (Klabatsa et al, 2005), whereas Kleinberg et al demonstrated survivin expression in 64 % of malignant pleural mesothelioma patients included in their study (Kleinberg et al, 2007). In comparison, in our recently published paper, all (100 %) of the malignant pleural mesothelioma specimens from 101 patients analysed were survivin positive, with a median level of 67 % of survivin positive tumour cell nuclei (Hmeljak et al, 2011 (Hmeljak et al, 2011) *Only patients with malignant pleural mesothelioma are included, although some of the studies comprised malignant peritoneal mesothelioma and reactive pleuritis patients. Table 2.…”

Section: Prognostic Rolesupporting

confidence: 82%

The Central Role of Survivin in Proliferation and Apoptosis of Malignant Pleural Mesothelioma

Hmeljak¹,

Cör²

2012

Mesotheliomas - Synonyms and Definition, Epidemiology, Etiology, Pathogenesis, Cyto-Histopathological Features, Clinic, Diagnos

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Section: Prognostic Rolesupporting

confidence: 82%

The Central Role of Survivin in Proliferation and Apoptosis of Malignant Pleural Mesothelioma

Hmeljak¹,

Cör²

2012

Mesotheliomas - Synonyms and Definition, Epidemiology, Etiology, Pathogenesis, Cyto-Histopathological Features, Clinic, Diagnos

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“…Several studies have now indicated that higher levels of XIAP may contribute to chemotherapy resistance in mesothelioma cells (32,33). Survivin was also found actively expressed in MPM (32,34) and it has an important role in maintaining apoptosis resistance. It can partially block activation of caspases due to its ability to bind to activated caspases (35,36).…”

Section: Discussionmentioning

confidence: 99%

Overexpression of Numb suppresses tumor cell growth and enhances sensitivity to cisplatin in epithelioid malignant pleural mesothelioma

Kang

Ding

Tian³

et al. 2013

Oncology Reports

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Abstract. Malignant pleural mesothelioma (MPM) is a highly aggressive and conventional treatment-resistant tumor with a dismal prognosis. Among the three histological subtypes of MPM, the epithelioid is the most common type. Numb is considered as a tumor suppressor playing a critical role in controlling asymmetric cell division, maintenance of stem cell compartments, ubiquitination of specific substrates and regulating Notch-, Hedgehog-and TP53-activated pathways. The present study was designed to analyze the role of Numb in epithelioid MPM. We investigated the expression of Numb in 39 epithelioid MPM and 22 normal pleural tissues by immunohistochemistry. Furthermore, we overexpressed Numb in NCI-H2452, an epithelioid human MPM cell line, and investigated the effect of Numb overexpression on the proliferation, apoptosis and sensitivity to cisplatin in cells. The expression of Numb was significantly lower in MPM compared to the control group and Numb had an inverse correlation with the Ki-67 labeling index. Loss of Numb expression was associated with poor prognosis in epithelioid MPM. Overexpression of Numb in NCI-H2452 cells significantly inhibited proliferation, promoted apoptosis and enhanced sensitivity to cisplatin. Moreover, Numb overexpression activated caspase-9 and caspase-3 through release of cytochrome c as well as downregulation of XIAP and survivin. We speculate that cytochrome c/caspase signaling is a possible mechanism through which Numb enhances the apoptosis of NCI-H2452 cells. These results suggest that Numb may be involved in epithelioid MPM development, and its upregulation may confer sensitivity to cisplatin, suggesting potential therapeutic options for MPM.

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“…One aspect of cancer is that apoptosis is uninhibited. Survivin, an inhibitor-of-apoptosis protein, is encoded by BIRC5, a gene that is linked to the regulation of apoptosis and cell division (Moore et al, 2014;Hmeljak et al, 2011). Studies have shown that BIRC5 is a biomarker for Oral Squamous Cell Carcinoma as well as breast, liver and prostate cancer.…”

Section: P53_signaling_pathwaymentioning

confidence: 99%

Identification of core genes associated with prostate cancer progression and outcome via bioinformatics analysis in multiple databases

Wang

Yan

et al. 2020

PeerJ

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The morbidity and mortality of prostate carcinoma has increased in recent years and has become the second most common ale malignant carcinoma worldwide. The interaction mechanisms between different genes and signaling pathways, however, are still unclear. Methods Variation analysis of GSE38241, GSE69223, GSE46602 and GSE104749 were realized by GEO2R in Gene Expression Omnibus database. Function enrichment was analyzed by DAVID.6.8. Furthermore, the PPI network and the significant module were analyzed by Cytoscape, STRING and MCODE.GO. Pathway analysis showed that the 20 candidate genes were closely related to mitosis, cell division, cell cycle phases and the p53 signaling pathway. A total of six independent prognostic factors were identified in GSE21032 and TCGA PRAD. Oncomine database and The Human Protein Atlas were applied to explicit that six core genes were over expression in prostate cancer compared to normal prostate tissue in the process of transcriptional and translational. Finally, gene set enrichment were performed to identified the related pathway of core genes involved in prostate cancer. Result Hierarchical clustering analysis revealed that these 20 core genes were mostly related to carcinogenesis and development. CKS2, TK1, MKI67, TOP2A, CCNB1 and RRM2 directly related to the recurrence and prognosis of prostate cancer. This result was verified by TCGA database and GSE21032. Conclusion These core genes play a crucial role in tumor carcinogenesis, development, recurrence, metastasis and progression. Identifying these genes could help us to understand the molecular mechanisms and provide potential biomarkers for the diagnosis and treatment of prostate cancer.

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BIRC5 promoter SNPs do not affect nuclear survivin expression and survival of malignant pleural mesothelioma patients

Abstract: Our findings indicate no relationship between BIRC5 genotypes and survivin expression or overall survival in mesothelioma patients. We observed that BIRC5 -241C > T polymorphism had a significant effect on patient age at diagnosis.

Cited by 19 publications

References 46 publications

The Central Role of Survivin in Proliferation and Apoptosis of Malignant Pleural Mesothelioma

The Central Role of Survivin in Proliferation and Apoptosis of Malignant Pleural Mesothelioma

Overexpression of Numb suppresses tumor cell growth and enhances sensitivity to cisplatin in epithelioid malignant pleural mesothelioma

Identification of core genes associated with prostate cancer progression and outcome via bioinformatics analysis in multiple databases

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