Birch pollen‐specific subcutaneous immunotherapy reduces <scp>ILC</scp>2 frequency but does not suppress <scp>IL</scp>‐33 in mice

Rijt, Leonie S. van; Logiantara, A.; Canbaz, Derya; Ree, Ronald van

doi:10.1111/cea.13254

Cited by 15 publications

(5 citation statements)

References 38 publications

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“…GM-CSF is known as a cytokine that induces differentiation of pluripotent hematopoietic stem cells into granulocyte-monocyte cells [23,24]. In relation to pollen allergy and GM-SCF, this cytokine has been reported to increase with IL-33 and IL-25 in animal models, and following the activation of neutrophils and antigen-specific T cells [25]. Additionally, one report has shown that IL-33 is activated by GM-CSF and IL-8 in the nasal mucosal epithelium of allergic rhinitis [26].…”

Section: Discussionmentioning

confidence: 99%

Effects of a Cloth Panel Containing a Specific Ore Powder on Patients with Japanese Cedar Pollen Allergy During the Pollen Dispersal Season

Lee

Yamamoto

Hamana³

et al. 2019

JCM

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Pollen allergy remains a big problem in contemporary societies. We have shown in previous studies that a cloth containing a special natural ore powder (CCSNOP) is effective in relieving symptoms in patients with pollen allergies. However, in that study, subjects were exposed to CCSNOP for only one hour. In the present study, CCSNOP or control (non-woven cloth; NWC) panels were placed in the bedrooms of pollen allergy patients for two weeks during the pollen dispersal season in 2018, and the effects were investigated. Twenty-one subjects were exposed to CCSNOP panels and 10 subjects were exposed to NWC panels. Our investigations showed that use of CCSNOP resulted in relief of symptoms and reduced use of therapeutics. Moreover, the ratio of eosinophil count decrease during exposure was higher in the CCSNOP group. Furthermore, a formula for measuring various cytokines and other parameters was established and clearly showed a distinction between the CCSNOP and NWC groups. In this formula, Granulocyte Macrophage colony-stimulating Factor (GM-SCF), Interleukin (IL)-12p40, Immunoglobulin (Ig) G4 and eosinophil count were extracted. These results indicated that CCNSNOP has a beneficial effect on pollen allergy patients. Future studies shall engage in long-term monitoring of pollen allergy patients who will utilize this mineral powder for at least one year.

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Section: Discussionmentioning

confidence: 99%

Effects of a Cloth Panel Containing a Specific Ore Powder on Patients with Japanese Cedar Pollen Allergy During the Pollen Dispersal Season

Lee

Yamamoto

Hamana³

et al. 2019

JCM

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“…A murine airway inflammation model demonstrated a reduced proportion of IL5 + ILC2s in the circulation without affecting innate ILC-activating cytokines IL-33 and IL-25 after a 2month birch pollen-SCIT [107]. In contrast, a 4-month GP-SCIT in humans failed to induce alterations of ILC2 frequencies in the periphery [80].…”

Section: Effect Of Ait On Innate Immune Responsesmentioning

confidence: 97%

Mechanisms of Allergen Immunotherapy in Allergic Rhinitis

Drazdauskaité

Layhadi

Shamji

2020

Curr Allergy Asthma Rep

109

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Purpose of Review Allergic rhinitis (AR) is a chronic inflammatory immunoglobulin (Ig) E-mediated disease of the nasal mucosa that can be triggered by the inhalation of seasonal or perennial allergens. Typical symptoms include sneezing, rhinorrhea, nasal itching, nasal congestion and symptoms of allergic conjunctivitis. AR affects a quarter of the population in the United States of America and Europe. Recent Findings AR has been shown to reduce work productivity in 36–59% of the patients with 20% reporting deteriorated job attendance. Moreover, 42% of children with AR report reduced at-school productivity and lower grades. Most importantly, AR impacts the patient’s quality of life, due to sleep deprivation. However, a proportion of patients fails to respond to conventional medication and opts for the allergen immunotherapy (AIT), which currently is the only disease-modifying therapeutic option. AIT can be administered by either subcutaneous (SCIT) or sublingual (SLIT) route. Both routes of administration are safe, effective, and can lead to tolerance lasting years after treatment cessation. Both innate and adaptive immune responses that contribute to allergic inflammation are suppressed by AIT. Innate responses are ameliorated by reducing local mast cell, basophil, eosinophil, and circulating group 2 innate lymphoid cell frequencies which is accompanied by decreased basophil sensitivity. Induction of allergen-specific blocking antibodies, immunosuppressive cytokines, and regulatory T and B cell phenotypes are key pro-tolerogenic adaptive immune responses. Conclusion A comprehensive understanding of these mechanisms is necessary for optimal selection of AIT-responsive patients and monitoring treatment efficacy. Moreover, it could inspire novel and more efficient AIT approaches.

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“… 21 , 22 Allergens such as ovalbumin and dust mites were used to sensitize and stimulate BALB/c mice to establish respiratory allergic inflammation mainly caused by Th2 mediated eosinophilic infiltration. 23 , 24 , 25 , 26 BALB/c mice immune responses tend to be Th2 response and are widely used for AR mice model. 27 However, C57BL/6 mice can be used as ILC2s mediated allergic inflammation, which reduce the influence of Th2 type adaptive immunity and better reflect the important role of innate immunity in respiratory allergic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Effect of parasympathetic inhibition on expression of ILC2 cells in a mouse model of allergic rhinitis

Wang

Zheng

et al. 2021

World Allergy Organization Journal

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Background We wanted to investigate whether parasympathetic inhibition affected the expression of type 2 innate lymphoid cells (ILC2s) in the nasal mucosa of a mouse model of allergic rhinitis (AR). Methods Thirty male C57BL/6 mice were randomly divided into 3 groups: control group, AR group, AR-treated group. AR nasal symptoms were assessed on a semi-quantitative scale according to the frequencies of nose rubbing and sneezing and the degree of rhinorrhea. The expression of cytokines protein in serum was detected by enzyme linked immunosorbent assay (ELISA). The number of ILC2s in nasal mucosa was detected by immunofluorescence double staining assay. Quantitative real-time Polymerase Chain Reaction (qPCR) was used to detect the expression of ILC2-associated factor in nasal mucosa. Results The symptom scores of the AR group were significantly higher than those of the control group and AR-treated group. The expression levels of mouse ovalbumin (OVA) specific IgE, IL4, IL5, and IL13 in the serum of AR group were significantly higher than those in the control group and AR-treated group. The number of ILC2s and the gene expression of ILC2s related factors GATA3, CD25 and CD90 (Thy1) in the nasal mucosa of the AR group were significantly higher than those of the control group and AR-treated group. Conclusions We found that parasympathetic inhibition relieved AR symptoms and inhibited immune response of AR mice. ILC2s play an important role in the occurrence and development of AR, and parasympathetic nerve inhibition reduced the number of ILC2s and inhibited the cytokines expression by ILC2s. Our data provide information on the mechanism of action of parasympathetic inhibition in AR.

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Birch pollen‐specific subcutaneous immunotherapy reduces ILC2 frequency but does not suppress IL‐33 in mice

Abstract: BP SCIT is able to suppress the adaptive and part of the innate immune response, but this is not sufficient to inhibit collagen deposition and the IL-33 expression in the airways in mice.

Cited by 15 publications

References 38 publications

Effects of a Cloth Panel Containing a Specific Ore Powder on Patients with Japanese Cedar Pollen Allergy During the Pollen Dispersal Season

Effects of a Cloth Panel Containing a Specific Ore Powder on Patients with Japanese Cedar Pollen Allergy During the Pollen Dispersal Season

Mechanisms of Allergen Immunotherapy in Allergic Rhinitis

Effect of parasympathetic inhibition on expression of ILC2 cells in a mouse model of allergic rhinitis

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