Birmingham Vasculitis Activity Score und der Short Form 36-Item Health Survey als Prädiktoren aktueller depressiver Störungen bei Patienten mit antineutrophile-zytoplasmatische-Antikörper-assoziierter Vaskulitis während der SARS-CoV-2-Pandemie

Abstract

Introduction This study compared the frequency and severity of depressive disorders in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) before and during the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic using the Korean version of the Center for Epidemiologic Studies Depression Scale-Revised (K-CESD-R) and the Korean version of the Profile of Mood States (K-POMS) depression, and further determined predictors of current depressive disorders in the patients during the pandemic. Methods Of the 61 patients with AAV who participated before the pandemic, 8 patients were transferred to other hospitals, 3 patients died, and 2 patients refused to participate in this study. Finally, 48 patients participated in this study. Depression disorders were defined as K‑CESD-R ≥ 16. Results When comparing the patterns of mental health between patients with AAV before and during the pandemic, no change in K‑CESD‑R or K‑POMS subscale scores was observed. Among AAV-related indices, regardless of the pandemic, the short-form 36-item Health Survey (SF-36) mental component score (MCS) and physical component score (PCS) were significantly correlated with K‑CESD‑R and could predict current depressive disorders. When the cut-off of Birmingham vasculitis activity score (BVAS) for depressive disorders was obtained by the receiver operator characteristic curve, it significantly predicted current depressive disorders in patients with AAV during the pandemic, unlike those before the pandemic. Conclusion We verified that SF-36 MCS and PCS could predict current depressive disorders, regardless of the pandemic, and furthermore, we demonstrated for the first time that BVAS was a predictor of current depressive disorders in patients with AAV during the pandemic unlike those before the pandemic. Supplementary Information The online version of this article (10.1007/s00393-022-01233-1) includes Figure S1 and Table S1.

Patient-reported outcomes in ANCA-associated vasculitis: a cross-sectional study to explore the interactions between patients’ and physicians’ perspectives

“…It is important to contextualize that the present study was conducted during the SARS-CoV-2 pandemic, which severely impacted Mexico as the rest of the world, resulting in an increased frequency of depressive disorders, limitations in daily life, and socioeconomic difficulties. Recent data have shown that outcome measurements in AAV patients, such as the BVAS score, were predictors of current depressive disorders during the pandemic, unlike those before the pandemic [ 32 ]. Therefore, it would be interesting to assess the AAV-PRO questionnaire and disease activity in the future to assess the variability in illness perceptions over time.…”