Birth characteristics in men with infertility

Liffner, Susanne; Nedstrand, Elizabeth; Bladh, Marie; Rodriguez‐Martinez, Heriberto; Hammar, Mats; Sydsjö, Gunilla

doi:10.1016/j.rbmo.2020.04.026

Cited by 2 publications

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Preterm birth is associated with a number of longterm health risks in both sexes such as infertility, accelerated ageing, insulin resistance and hypertension [6][7][8]. Thus, an understanding of the complex interactions between a mother's exposure, her and/or foetal lack of capacity to buffer environmental stressors which may lead to preterm birth with lifelong health consequences is of great importance.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Estradiol, Testostosterone, and CYP19 Methylation Levels between Full-Term and Preterm Newborns

et al. 2021

View full text Add to dashboard Cite

Estradiol (E), testosterone (T), and their ratio are crucial axis in life. Especially during intrauterine growth, they orchestrate the complex development of organs and their interaction, which have lifelong impact on health and an organism’s capacity to respond to environmental stressors. The aim of this study was to compare for the first time E, T, and their ratio levels with aromatase (CYP19) gene methylation levels between preterm newborns (PN) and full-term newborns (FN) with respect to their mother’s environmental exposure and diet. In this study, 56 FN of 37–42 weeks of gestation age (GA) and 46 PN at GA 27–36 weeks were analysed for E and T levels and CYP19A1 gene pI.3/II promoter region methylation. Results showed there was no difference in E levels between PN and FN, but there were significantly lower levels of T in PN than in FN (2.81 nmol vs. 3.76 nmol, respectively) and consequently a significantly higher E/T ratio in PN than in FN (5278.04 vs. 2891.23, respectively). CYP19A1 methylation was significantly lower in PN than in FN (86.04% vs. 90.04%, respectively). CYP19A1 methylation was significantly reduced in newborns whose mothers reported daily milk consumption. Our study is the first to provide referent values for CYP19A1 methylation levels in FN and PN and shows that PN and FN significantly differ in CYP19A1 methylation levels, T levels, and E/T ratio. Future research should further investigate the mechanisms involved in GA-dependent CYP19A1 methylation levels and mechanisms of sex hormone disturbances which may contribute to preterm birth.

show abstract

Section: Introductionmentioning

confidence: 99%

Comparison of Estradiol, Testostosterone, and CYP19 Methylation Levels between Full-Term and Preterm Newborns

et al. 2021

View full text Add to dashboard Cite

show abstract

The impact of impaired intrauterine growth on male fertility: A systematic review and meta‐analysis

Meng,

Yao,

et al. 2024

Andrology

View full text Add to dashboard Cite

BackgroundAdverse intrauterine environment was believed to have deleterious effects on the gonadal function. However, the association between impaired intrauterine growth and fertility in adult males has not been established.ObjectivesTo compare the reproductive rates of males born small for gestational age (SGA), with low birth weight (LBW) or very low birth weight (VLBW) with control groups.MethodsThe Preferred Reporting Items for Systematic reviews and Meta‐Analyses (PRISMA) statement was followed to search PubMed, Web of Science, Cochrane Library, and Embase databases from inception to June 16, 2023. Cohort studies investigating the reproductive rates of males born SGA, with LBW or VLBW were included. A random or fixed effects model was used for different exposures.ResultsA total of 10 studies out of 3,801 records were included. Males born SGA showed a higher risk of infertility than the control group (odds ratio, OR = 0.91, 95% confidence interval, 95% CI 0.89–0.93, p = 0.000). The reproductive rates of individuals born with LBW or VLBW were lower than the control group (OR = 0.86, 95% CI 0.78–0.94, p = 0.001; OR = 0.57, 95% CI 0.40–0.81, p = 0.002, respectively). Participants were further divided into two age groups of 18–35 and 35–45 years. In both subgroups, the reproductive rates were lower in males born SGA, with LBW or VLBW compared with controls. Sensitivity analysis showed the robustness of the pooled estimates among LBW and VLBW.ConclusionIn summary, SGA, LBW, and VLBW were associated with a higher risk of male infertility in both early and middle adulthood. Achieving optimal intrauterine growth would be helpful to prevent male infertility.

show abstract

Birth characteristics in men with infertility

Abstract: Her research focus is bio-psychosocial risks for women and children, reproduction, infertility, women's mental and somatic health, and short-and long-term outcomes for children.

Cited by 2 publications

References 44 publications

Comparison of Estradiol, Testostosterone, and CYP19 Methylation Levels between Full-Term and Preterm Newborns

Comparison of Estradiol, Testostosterone, and CYP19 Methylation Levels between Full-Term and Preterm Newborns

The impact of impaired intrauterine growth on male fertility: A systematic review and meta‐analysis

Contact Info

Product

Resources

About