Birth outcomes associated with maternal exposure to metals from informal electronic waste recycling in Guiyu, China

Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in placental trophoblasts

“…Increasing evidences showed that Cd was a main environmental stressor inducing FGR. Epidemiological studies found that maternal exposure to Cd during gestation markedly elevated the risk of intrauterine growth retardation [ [15] , [16] , [17] , [18] ]. Animal experiments further verified that gestational exposure to environmental Cd caused FGR [ [19] , [20] , [21] ].…”

Increased intestinal permeability with elevated peripheral blood endotoxin and inflammatory indices for e-waste lead exposure in children

“…Consistent with the result of this work, our previous investigations have found that Guiyu children experienced higher Pb exposure than children 0-6 years of age in China (geometric mean: 4.24 μg/dL, from 2012 to 2017), both exceed the blood Pb levels of U.S. children 1-5 years of age (geometric mean: 0.758 μg/dL, from 2015 to 2016) (CDC, 2019;Xu et al, 2020;Xu et al, 2015;Zhang et al, 2019). In addition to children, pregnant women in Guiyu also have higher blood Pb levels than referent groups, which may enhance the Pb levels in their infants' body (Kazi et al, 2014;Kim et al, 2020). Moreover, the proportion of children who had blood Pb levels over 5 μg/dL was elevated in the exposed group.…”

Metabolomics insights into the prenatal exposure effects of polybrominated diphenyl ethers on neonatal birth outcomes

“…Among them, 100 subjects were from an e-waste recycling town of Guiyu, and 100 from a reference district of Haojiang. The detailed information about both areas has been described before (Huang et al, 2020;Kim et al, 2020). The distributions of maternal age, height and pre-pregnancy weight and body mass index (BMI) in the two districts were matched (Mann-Whitney tests, p > 0.05).…”