Birth Weight, Head Circumference, and Prenatal Exposure to Acrylamide from Maternal Diet: The European Prospective Mother–Child Study (NewGeneris)

Pedersen, Marie; Stedingk, Hans von; Botsivali, Maria; Agramunt, Sílvia; Alexander, Jan; Brunborg, Gunnar; Chatzi, Leda; Fleming, Sarah; Fthenou, Eleni; Granum, Berit; Gützkow, Kristine B.; Hardie, Laura J.; Knudsen, Lisbeth E.; Kyrtopoulos, Soterios A.; Mendez, Michelle A.; Merlo, Domenico Franco; Nielsen, Jeanette K.; Rydberg, Per; Segerbäck, Dan; Sunyer, Jordi; Wright, John; Törnqvist, Margareta; Kleinjans, Jos; Kogevinas, Manolis

doi:10.1289/ehp.1205327

Cited by 101 publications

(86 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Again, a highly significant correlation was observed between cord and maternal blood with regard to the Hb adducts of AA and also GA, for which the adduct ratio of cord to maternal blood was around 0.38. Similarly, in a study which included 1 101 cord blood samples and 172 maternal blood samples from Greece, Spain, England, Denmark and Norway (Pedersen et al, 2012), the median AA-Hb adduct levels in cord blood were approximately half of the levels in paired maternal blood. Hb adduct levels in cord blood were positively correlated with both maternal AA-Hb adduct (r = 0.95) and GA-Hb adducts (r = 0.94).…”

Section: Placental Transfermentioning

confidence: 93%

“…Huang et al (2012) studied 51 AA-exposed workers and 34 controls to explore the effect of genetic polymorphisms of CYP2E1, mEH3, mEH4, GSTT1 and GSTM1 on AA and GA-Hb adduct levels. The results suggest that mEH4 and the combined genotypes of CYP2E1, GSTM1 and mEH4 may be associated with the formation of AAVal and GAVal (Huang et al, 2012) The effects of prenatal exposure to AA measured by determinations of AA-and GA-Hb adducts on birth weight and head circumference (Pedersen et al, 2012) is described in Section 7.4.2. In this study, which used cord blood samples from Greece, Spain, England, Denmark and Norway, it was observed that the median AA-Hb and GA-Hb adduct levels were higher in cord blood from children of mothers who smoked (n = 129) than in children of non-smokers (n = 972).…”

Section: Human Studiesmentioning

confidence: 99%

“…In a prospective mother child study with 1 101 singleton pregnant women from Denmark, England, Greece, Norway and Spain it was investigated whether AA and GA exposures are associated with the development of the child during pregnancy (Pedersen et al, 2012). AA and GA adduct levels were measured in cord blood.…”

Section: Developmental Consequencesmentioning

confidence: 99%

See 2 more Smart Citations

Scientific Opinion on acrylamide in food

Publication¹

2015

EFS2

341

170

View full text Add to dashboard Cite

EFSA was asked to deliver a scientific opinion on acrylamide (AA) in food. AA has widespread uses as an industrial chemical. It is also formed when certain foods are prepared at temperatures above 120 °C and low moisture, especially in foods containing asparagine and reducing sugars. The CONTAM Panel evaluated 43 419 analytical results from food commodities. AA was found at the highest levels in solid coffee substitutes and coffee, and in potato fried products. Mean and 95th percentile dietary AA exposures across surveys and age groups were estimated at 0.4 to 1.9 µg/kg body weight (b.w.) per day and 0.6 to 3.4 µg/kg b.w. per day, respectively. The main contributor to total dietary exposure was generally the category 'Potato fried products (except potato crisps and snacks)'. Preferences in home-cooking can have a substantial impact on human dietary AA exposure. Upon oral intake, AA is absorbed from the gastrointestinal tract and distributed to all organs. AA is extensively metabolised, mostly by conjugation with glutathione but also by epoxidation to glycidamide (GA). Formation of GA is considered to represent the route underlying the genotoxicity and carcinogenicity of AA. Neurotoxicity, adverse effects on male reproduction, developmental toxicity and carcinogenicity were identified as possible critical endpoints for AA toxicity from experimental animal studies. The data from human studies were inadequate for dose-response assessment. The CONTAM Panel selected BMDL 10 values of 0.43 mg/kg b.w. per day for peripheral neuropathy in rats and of 0.17 mg/kg b.w. per day for neoplastic effects in mice. The Panel concluded that the current levels of dietary exposure to AA are not of concern with respect to non-neoplastic effects. However, although the epidemiological associations have not demonstrated AA to be a human carcinogen, the margins of exposure (MOEs) indicate a concern for neoplastic effects based on animal evidence. © European Food SUMMARYFollowing a request from the European Commission, the Panel on Contaminants in the Food Chain (CONTAM Panel) was asked to deliver a scientific opinion on acrylamide (AA) in food. The Panel developed the draft scientific opinion which underwent a public consultation from 1 July 2014 to 15 September 2014. The comments received and how they were taken into account when finalising the scientific opinion were published in an EFSA Technical Report (EFSA, 2015).AA is a low molecular weight, highly water soluble, organic compound. It is used inter alia as an industrial chemical and in the production of polyacrylamides. Heightened concerns about exposure to AA arose in 2002 when it was discovered that it forms when certain foods are prepared at temperatures usually above 120 °C and low moisture. It forms, at least in part, due to a Maillard reaction between certain amino acids, such as asparagine, and reducing sugars. However, several other pathways and precursors have also been proposed to contribute to AA formation. AA forms in numerous baked or fried carbohydrate-rich f...

show abstract

Section: Placental Transfermentioning

confidence: 93%

Section: Human Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Scientific Opinion on acrylamide in food

Publication¹

2015

EFS2

341

170

View full text Add to dashboard Cite

show abstract

“…There are also indications that the food-borne non-proteinogenic amino acid BMAA affects neurodevelopment (Karlsson et al, 2015). The same is true for acrylamide, a chemical generated from amino acid precursors during food processing (Duarte-Salles et al, 2013;Pedersen et al, 2012). However, more information regarding specificity is required; for example, acrylamide's effects on head circumference and brain weight may also be indirect consequences of toxicity.…”

Section: Examples Of Other Compounds Not Considered Herementioning

confidence: 99%

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: Example lists and criteria for their selection and use_suppl

Aschner

2017

ALTEX

View full text Add to dashboard Cite

SummaryThere is a paucity of information concerning the developmental neurotoxicity (DNT) hazard posed by industrial and environmental chemicals. New testing approaches will most likely be based on batteries of alternative and complementary (non-animal) tests. As DNT is assumed to result from the modulation of fundamental neurodevelopmental processes (such as neuronal differentiation, precursor cell migration or neuronal network formation) by chemicals, the first generation of alternative DNT tests target these processes. The advantage of such types of assays is that they capture toxicants with multiple targets and modes-of-action. Moreover, the processes modelled by the assays can be linked to toxicity endophenotypes, i.e., alterations in neural connectivity that form the basis for neurofunctional deficits in man. The authors of this review convened in a workshop to define criteria for the selection of positive/negative controls, to prepare recommendations on their use, and to initiate the setup of a directory of reference chemicals. For initial technical optimization of tests, a set of > 50 endpoint-specific control compounds was identified. For further test development, an additional "test" set of 33 chemicals considered to act directly as bona fide DNT toxicants is proposed, and each chemical is annotated to the extent it fulfills these criteria. A tabular compilation of the original literature used to select the test set chemicals provides information on statistical procedures, and toxic/non-toxic doses (both for pups and dams). Suggestions are provided on how to use the > 100 compounds (including negative controls) compiled here to address specificity, adversity and use of alternative test systems.

show abstract

“…As a follow up of a study (54) that showed a negative association between a biological marker of acrylamide exposure and foetal growth (women from five European cohorts, including MoBa, total n=1,101), the association between calculated dietary acrylamide intake and foetal growth was examined in 50,561 women in MoBa. Calculated acrylamide intake showed strong correlation with haemoglobin-and glycidamide Hb-adducts in a subset of the participating women.…”

Section: Maternal Diet and Infant Size At Birthmentioning

confidence: 99%

Diet matters, particularly in pregnancy – Results from MoBa studies of maternal diet and pregnancy outcomes

Brantsæter¹,

Haugen²,

Myhre³

et al. 2014

Nor J Epidemiol

Self Cite

View full text Add to dashboard Cite

Awareness that maternal diet may influence the outcome of pregnancy as well as the long-term health of mother and child has increased in recent years. A new food frequency questionnaire (FFQ) was developed and validated specifically for the Norwegian Mother and Child Cohort Study (MoBa). The MoBa FFQ is a semi-quantitative tool which covers the average intake of food, beverages and dietary supplements during the first 4 to 5 months of pregnancy. It includes questions about intakes of 255 foods and dishes and was used from 2002 onwards. Data assessed by the MoBa FFQ is available for 87,700 pregnancies. Numerous sub-studies have examined associations between dietary factors and health outcomes in MoBa. The aim of this paper is to summarize the results from 19 studies of maternal diet and pregnancy outcomes, which is the complete collection of studies based on the MoBa FFQ and published before September 2014. The overall research question is whether maternal diet -from single substances to dietary patterns -matters for pregnancy outcome. The pregnancy outcomes studied till now include birth size measures, infants being small and large for gestational age, pregnancy duration, preterm delivery, preeclampsia, as well as maternal gestational weight gain and postpartum weight retention. As a whole, the results from these studies corroborate that the current dietary recommendations to pregnant women are sound and that maternal diet during pregnancy is likely to contribute to reduce the risk of pregnancy complications including preterm birth, preeclampsia, and reduced foetal growth. The results provide supporting evidence for recommending pregnant women to consume vegetables, fruit, whole grain, fish, dairy, and water regularly and lower the intake of sugar sweetened beverages, processed meat products and salty snacks. The results showing negative impact of even low levels of environmental contaminants support the precautionary advice on consumption of foods containing these. New findings are that particularly lean fish explained the positive association between seafood intake and foetal growth, and the indications of a protective effect of probiotic and antimicrobial foods on pregnancy outcomes. This points to the importance of diet composition for a healthy gut flora and the body's immune response. Although these studies are observational and cannot infer causality, the results identify diet as an important modifiable lifestyle factor, suggesting that healthy eating, defined as following the official recommendations, is particularly important in pregnancy.This is an open access article distributed under the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

Birth Weight, Head Circumference, and Prenatal Exposure to Acrylamide from Maternal Diet: The European Prospective Mother–Child Study (NewGeneris)

Cited by 101 publications

References 28 publications

Scientific Opinion on acrylamide in food

Scientific Opinion on acrylamide in food

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: Example lists and criteria for their selection and use_suppl

Diet matters, particularly in pregnancy – Results from MoBa studies of maternal diet and pregnancy outcomes

Contact Info

Product

Resources

About