Bis(acetylamido)oxovanadium(IV) complexes: solid state and solution studies

Crans, Debbie C.; Khan, Arfhan; Mahroof-Tahir, Mohammad; Mondal, Sujit; Miller, Susie M.; Cour, Agnete la; Anderson, Oren P.; Jakusch, Tamás; Kiss, TamÃ¡s

doi:10.1039/b101718g

Cited by 37 publications

(52 citation statements)

References 24 publications

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“…This is in agreement with previous studies on the stability of these complexes [9,32] which follows the order 1~2>>3~4.…”

Section: Effect Of the Stability Of The Complexsupporting

confidence: 93%

“…Based on stability constant data reported for complexes 1, 3 and 4 [32], the distribution shown in Fig. 12 is expected at milimolar and micromolar levels.…”

Section: Mechanism and Nature Of The Active Species For Dna Cleavagementioning

confidence: 72%

“…However, we observed that the vanadyl ion by itself does not promote DNA cleavage, while V IV O(acac) 2 , on the other hand, does it very efficiently, so if cleavage at the phosphodiester linkage is occurring, the nature of the ligand is also relevant in this process. [32] report two (V=O) bands for solid complexes 3 and 4, which should correspond to the two trans isomers of symmetry C s and C 2 . We also observed similar bands in the IR spectra of these compounds, but in our opinion the bands cannot be undoubtly assigned to (V=O) absorptions.…”

Section: Accepted Manuscriptmentioning

confidence: 94%

“…X-ray crystallography of 1 shows only the trans isomer in the solid state. Experimental evidence by ENDOR [28] and EPR [30] points to the formation of only the trans isomer of V IV O(acac) 2 in solution, but some authors argue the cis form may also exist [9,7,32].…”

Section: Mechanism and Nature Of The Active Species For Dna Cleavagementioning

confidence: 99%

“…For 3 and 4, this species is predominant at pH 6 when the ligand-to-metal ratio is 80 [32]. We tested the activity of 1, 3 and 4 in the presence of excess ligand with L/M ratios between 2 and 324 ( Fig.…”

Section: Mechanism and Nature Of The Active Species For Dna Cleavagementioning

confidence: 99%

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DNA cleavage activity of VIVO(acac)2 and derivatives

Butenko

Tomaz

Nouri

et al. 2009

Journal of Inorganic Biochemistry

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“…This is in agreement with previous studies on the stability of these complexes [9,32] which follows the order 1~2>>3~4.…”

Section: Effect Of the Stability Of The Complexsupporting

confidence: 93%

“…Based on stability constant data reported for complexes 1, 3 and 4 [32], the distribution shown in Fig. 12 is expected at milimolar and micromolar levels.…”

Section: Mechanism and Nature Of The Active Species For Dna Cleavagementioning

confidence: 72%

Section: Accepted Manuscriptmentioning

confidence: 94%

Section: Mechanism and Nature Of The Active Species For Dna Cleavagementioning

confidence: 99%

Section: Mechanism and Nature Of The Active Species For Dna Cleavagementioning

confidence: 99%

See 3 more Smart Citations

DNA cleavage activity of VIVO(acac)2 and derivatives

Butenko

Tomaz

Nouri

et al. 2009

Journal of Inorganic Biochemistry

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Effect of solvent coordination on the structure of β‐diketone‐based vanadyl complexes and assessment of in vitro antidiabetic activity and cytotoxicity

Chinthala

Sheela

2017

Applied Organom Chemis

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The physicochemical properties, thereby the biological efficacy, of metal complexes are affected based on their structure and geometry that vary in the presence of coordinating and non-coordinating solvents. To investigate this, in the present work, we synthesized three hitherto unreported β-diketone-based oxovanadium(IV) complexes, namely [VO(tfdmh) 2 ] (tfdmh =1,1,1-trifluro-5,5dimethyl-2,4-hexanedione), [VO(dmh) 2 ] (dmh = 2,2-dimethyl-3,5-hexanedione) and [VO(dbm) 2 ] (dbm = 1,3-diphenylpropane-1,3-dione), and characterized them using electron paramagnetic resonance, UV-visible, Fourier transform infrared and electrospray ionization mass spectroscopies and single-crystal X-ray diffraction. The structural changes in the presence of dichloromethane, dimethylsulfoxide and dimethylformamide were analysed using spectroscopic techniques. Further, in vitro glucose uptake efficacy and cytotoxicity were assessed using C2C12 (rat skeletal muscle) and HeLa (human cervical cancer) cell lines, respectively.

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Solvent‐free oxidation of straight‐chain aliphatic primary alcohols by polymer‐grafted vanadium complexes

Kachhap

Chaudhary

Haldar

2021

Applied Organom Chemis

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Oxidovanadium(IV) complexes [VO(tertacac)2] (1), [VO(dipd)2] (2), and [VO(phbd)2] (3) were synthesized by reacting [VO(acac)2] with 2,2,6,6‐tetramethyl‐3,5‐hepatanedione, 1,3‐diphenyl‐1,3‐propanedione, and 1‐phenyl‐1,3‐butanedione, respectively. Imidazole‐modified Merrifield resin was used for the heterogenization of complexes 1–3. During the process of heterogenization, the V4+ center in complex 2 converts into V5+, whereas the other two complexes 1 and 3 remain in the oxidovanadium(IV) state in the polymer matrix. Theoretically, calculated IPA values of 1–3 suggest that 2 is prone to oxidation compared with 1 and 3, which was also supported by the absence of EPR lines in 5. Polymer‐supported complexes Ps‐Im‐[VIVO(tertacac)2] (4), Ps‐Im‐[VVO2(dipd)2] (5), and Ps‐Im‐[VIVO(phbd)2] (6) were applied for the solvent‐free heterogenous oxidation of a series of straight‐chain aliphatic alcohols in the presence of H2O2 at 60°C and showed excellent substrate conversion specially for the alcohols with fewer carbon atoms. Higher reaction temperature improves the substrate conversion significantly for the alcohols containing more carbon atoms such as 1‐pentanol, 1‐hexanol, and 1‐heptanol while using optimized reaction conditions. However, alcohols with fewer carbon atoms seem less affected by reaction temperatures higher than the optimized temperature. A decreasing trend in the selectivity(%) of carboxylic acid was observed with increasing carbon atoms among the examined alcohols, whereas the selectivity towards aldehydes increased. The order of efficiency of the supported catalysts is 4 > 6 > 5 in terms of turnover frequency (TOF) values and substrate conversion, further supported by theoretical calculations.

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Bis(acetylamido)oxovanadium(IV) complexes: solid state and solution studies

Cited by 37 publications

References 24 publications

DNA cleavage activity of VIVO(acac)2 and derivatives

DNA cleavage activity of VIVO(acac)2 and derivatives

Effect of solvent coordination on the structure of β‐diketone‐based vanadyl complexes and assessment of in vitro antidiabetic activity and cytotoxicity

Solvent‐free oxidation of straight‐chain aliphatic primary alcohols by polymer‐grafted vanadium complexes

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