Biseko® colloidal solution diminishes the vasoreactivity of human isolated radial arteries☆

Abstract

Our results suggest that storage of radial artery in Biseko colloidal solution before coronary artery bypass grafting decreases the sensitivity of the graft to vasoconstriction, thereby decreasing the risk of intra/perioperative graft failure.

Levosimendan has a prolonged antispasmodic effect in isolated human radial artery bypass grafts and inhibits thrombin-induced aggregation of human platelets in vitro

“…The explanation of this low endothelial function is that the diseases that determine the reactivity of the arterial wall (hypertension, hypercholesterolemia, diabetes) were found to be severe (see Table 3). This depressed endothelium was similar in the controls and in the levosimendan-treated grafts representing a poor cardiovascular status being comparable to our previous populations of patients undergoing CABG [30,31]. We suggest that the poor endothelial function was not due to a mechanical damage of the blood vessel (atraumatic ultrasound technique, no inflation of the artery) but rather represented a severely diseased population of our patients compared to other centers of cardiac surgery [70][71][72].…”

“…Papaverine has been widely used for the prevention of RA vasospasm, however, it was shown to impair endothelial function [29]. We have recently shown that a colloidal solution (Biseko® solution) without the addition of a vasodilator substance was able to diminish contractions to 5-HT while the RA graft retained its maximal vasoconstrictive and vasodilating capacities [30]. Vasodilators other than papaverine have also been used in pre-incubation solutions to minimize perioperative spasm of RA grafts.…”

“…RA from the non-dominant forearm of patients was used in this study. Modified Allen test using the standard Allen test [44] together with Doppler test [45] on the hand was used to determine the eligibility of the patients.…”

“…It is known that RA has a higher receptormediated contractility (endothelin-1, angiotensin II [25], 5-hydroxytryptamine [26]) but similar endothelial function compared to the IMA. In order to reduce the incidence of spasm, preparation of the RA is atraumatic, the RA grafts are usually pre-incubated in crystalloid or colloidal solutions for [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] minutes before the surgical implantation, and the patients are given a vasodilator infusion during the surgery. Pharmacological dilatation is used instead of mechanical dilatation.…”

Potent Vasodilatory Effect of Fasudil on Radial Artery Graft in Coronary Artery Bypass Operations

“…The concentrations of papaverine varied widely from 30 μmol/L to 2.6 mmol/L. In the present study, we used the middle concentration of 1.0 mmol/L, which is also used in internal thoracic artery grafts [9,[10][11][12][13][14]. In the VG group, 2 mL of VG solution was injected.…”