Bismuth compounds in medicine

Udalova, T. A.; Logutenko, O. A.; Timakova, Evgeniya V.; Afonina, L. I.; Naydenko, E. S.; Yukhin, Yu. M.

doi:10.1109/ifost.2008.4602849

Cited by 15 publications

(13 citation statements)

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“…In addition, investigation of metal cations cytotoxicity used in dental cast alloys showed that the TC 50 (toxic concentration by which 50% of the cells in a culture are killed) of In 3+ and Ga 3+ for L929 cells was 2310 μM (263.23 mg/L) and 1530 μM (106.67 mg/L), respectively, which were much higher than that of other toxic metal ions such as Zn 2+ , Hg 2+ and Cd 2+ 33. Bi is also recognized as a less toxic heavy metal element and has minimum threat to the environment, and the medicinal application of Bi compounds has a history of over 250 years3435. In our previous study22, it was also proved that the Ti‒Bi alloys produced no significant deleterious effect to L929 cells and MG63 cells.…”

Section: Discussionmentioning

confidence: 97%

Screening on binary Ti alloy with excellent mechanical property and castability for dental prosthesis application

Qiu

Yuan

et al. 2016

Sci Rep

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In the present study, the microstructure, mechanical property, castability, corrosion behavior and in vitro cytocompatibility of binary Ti–2X alloys with various alloying elements, including Ag, Bi, Ga, Ge, Hf, In, Mo, Nb, Sn and Zr, were systematically investigated, in order to assess their potential applications in dental field. The experimental results showed that all binary Ti‒2X alloys consisted entirely α–Ti phase. The tensile strength and microhardness of Ti were improved by adding alloying elements. The castability of Ti was significantly improved by separately adding 2 wt.% Bi, Ga, Hf, Mo, Nb, Sn and Zr. The corrosion resistance of Ti in both normal artificial saliva solution (AS) and extreme artificial saliva solution (ASFL, AS with 0.2 wt.% NaF and 0.3 wt.% lactic acid) has been improved by separately adding alloying elements. In addition, the extracts of studied Ti‒2X alloys produced no significant deleterious effect to both fibroblasts L929 cells and osteoblast-like MG63 cells, indicating a good in vitro cytocompatibility, at the same level as pure Ti. The combination of enhanced mechanical properties, castability, corrosion behavior, and in vitro cytocompatibility make the developed Ti‒2X alloys have great potential for future stomatological applications.

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Section: Discussionmentioning

confidence: 97%

Screening on binary Ti alloy with excellent mechanical property and castability for dental prosthesis application

Qiu

Yuan

et al. 2016

Sci Rep

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“…Meanwhile, the oxide itself shows low solubility and good biocompatibility. The alloying element Bi is also recognized as a less toxic heavy metal element and has minimum threat to the environment [37]. In this study, the cytotoxicity test results showed that both L929 and MG63 cells exhibited a good cell proliferation and attachment on the surface of Ti-Bi alloys.…”

Section: In Vitro Biocompatibility and Hemocompatibilitymentioning

confidence: 98%

“…With respect to the effect of Bi on alloys' castability, a few previous studies demonstrated that a minor amount (1 wt.%) of Bi could improve the castability of Ti and Ti alloys significantly in a copper mold with a needle-shaped cavity [33][34][35]. Moreover, Bi is one of the low toxic heavy metals and has minimum threat to the environment, and the medicinal application of Bi compounds has a history of over 250 years [36,37]. Bi compounds were primarily used clinically for the treatment of ulcers, and they were also considered to have anti-cancer activity [38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Microstructure, mechanical properties, castability and in vitro biocompatibility of Ti–Bi alloys developed for dental applications

et al. 2015

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“…Bismuth compounds have been used in cosmetic and pharmaceutical industry for over than 250 years [9][10][11]. This metal is widely used like antimicrobial agent for the eradication of individual strains as D DAVID PUBLISHING Helicobacteri pylori and reduction of biofilm formation by Pseudomonas aeruginosa and Staphylococcus [12][13][14][15][16], in the treatment of general gastrointestinal disorders, syphilis and tumors, which has been discussed in several reviews [17,18].…”

Section: Introduction mentioning

confidence: 99%

Bismuth and Silver Nanoparticles as Antimicrobial Agent over Subgingival Bacterial and Nosocomial Strains

Campos¹,

Almaguer‐Flores²,

Velasco-Aria³

et al. 2018

JMSE-A

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Bismuth compounds are used in the treatment of gastrointestinal infections due to its effectiveness against Helicobacter pylori as Gram-negative bacteria. Moreover, the nanometric materials show better biological properties that the materials in block. The aim of this study was to determine the MICs (minimal inhibitory concentrations) of three colloidal dispersions of bismuth nanoparticles compared with silver nanoparticles against oral and nosocomial bacteria. The nanoparticles were synthesized by chemical reduction in DMSO. The MICs of each colloidal dispersion were obtained on eight species representative of the subgingival biofilm, as well as in three species of medical importance: Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. All bismuth compounds showed antimicrobial effect on the tested bacterial species, with MICs between 37 to 329 µg/mL. On the other hand, AgNPs showed MICs from 16 to 32 µg/mL for the bacteria of subgingival biofilm and from 32 to 65 µg/mL for the species of medical importance. In accordance with this study, the different BiNPs had an antimicrobial effect in all the bacterial species, although with a potency lower than AgNPs. to the dental surface by means of specific molecules [5,6], such as Streptococcus spp and Actinomyces spp. Then, the bridge settlers or secondary bacteria, which include species like Fusobacterium nucleatum,

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Bismuth compounds in medicine

Cited by 15 publications

References 1 publication

Screening on binary Ti alloy with excellent mechanical property and castability for dental prosthesis application

Screening on binary Ti alloy with excellent mechanical property and castability for dental prosthesis application

Microstructure, mechanical properties, castability and in vitro biocompatibility of Ti–Bi alloys developed for dental applications

Bismuth and Silver Nanoparticles as Antimicrobial Agent over Subgingival Bacterial and Nosocomial Strains

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