Bisphenol A, bisphenol F and bisphenol S affect differently 5α-reductase expression and dopamine–serotonin systems in the prefrontal cortex of juvenile female rats

Castro, Beatriz; Sánchez, Pablo Tercedor; Torres, Juan Antonio Vera; Ortega, Esperanza

doi:10.1016/j.envres.2015.07.001

Cited by 103 publications

(50 citation statements)

References 61 publications

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“…Several rodent studies have shown that BPA exposure can reduce maternal and even paternal care [15; 22; 72; 76]. The current studies indicate that BPA-alternatives can alter gene involved in the dopamine-serotonin systems in the prefrontal cortex, which might account for some of the observed behavioral disruptions [65]. This study also showed similar findings with BPA.…”

Section: Neuroendocrine Disruption Due To Exposure Of Rodent Models Tsupporting

confidence: 81%

“…Wistar female rats were treated with vehicle or 10 μg/kg/day BPA, BPF, or BPS from GD 12 through parturition, and female pups were exposed to the respective chemicals from PND day 1 through 21; whereupon female offspring were euthanized and expression patterns in the prefrontal brain cortex analyzed [65]. BPA decreased 5α-reductase 3 ( Srd5a3 ) mRNA and protein levels; whereas, BPF and BPS reduced only the mRNA expression for this gene.…”

Section: Neuroendocrine Disruption Due To Exposure Of Rodent Models Tmentioning

confidence: 99%

“…Developmental or adult exposure of animal models to BPA-substitutes leads to several behavioral disruptions, including an increase in anxiogenic and hyperactive behaviors, compromised social interactions and parental care ability, and delayed habituation responses [62; 63; 64; 99; 107]. The collective data to date suggests that these chemicals can affect gene expression in the prefrontal cortex, hypothalamus, MPOA region, and likely other brain areas [28; 64; 65; 100; 103; 105]. These other bisphenols also induce hormonal imbalances in E2 synthesis and circulating concentrations, T levels, and thyroid hormone production [28; 66; 101; 102; 103; 104; 105].…”

Section: Overall Conclusionmentioning

confidence: 99%

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Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

Rosenfeld

2017

Frontiers in Neuroendocrinology

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Animal and human studies provide evidence that exposure to the endocrine disrupting chemical (EDC), bisphenol A (BPA), can lead to neurobehavioral disorders. Consequently, there is an impetus to identify safer alternatives to BPA. Three bisphenol compounds proposed as potential safer alternatives to BPA are bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF). However, it is not clear whether these other compounds are safer in terms of inducing less endocrine disrupting effects in animals and humans who are now increasingly coming into contact with these BPA-substitutes. In the past few years, several animal studies have shown exposure to these other bisphenols induce similar neurobehavioral disruption as BPA. We will explore in this review article the current studies suggesting these other bisphenols result in neuroendocrine disruptions that may be estrogen receptor-dependent. Current work may aide in designing future studies to test further whether these BPA-substitutes can act as neuroendocrine disruptors.

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Section: Neuroendocrine Disruption Due To Exposure Of Rodent Models Tsupporting

confidence: 81%

Section: Neuroendocrine Disruption Due To Exposure Of Rodent Models Tmentioning

confidence: 99%

Section: Overall Conclusionmentioning

confidence: 99%

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Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

Rosenfeld

2017

Frontiers in Neuroendocrinology

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“…Although BPS has not been examined extensively, several studies indicate that this compound displays estrogenic properties in both genomic and membrane-associated estrogen signaling similar to BPA (39)(40)(41). To date, studies of BPS in mammals are limited, and there are very few studies investigating the effects of exposure on behavior or brain (42,43). Furthermore, to our knowledge, there are no studies examining whether this compound disrupts maternal behavior or the maternal brain.…”

mentioning

confidence: 91%

Bisphenol S (BPS) alters maternal behavior and brain in mice exposed during pregnancy/lactation and their daughters

Catanese

Vandenberg

2016

Endocrinology

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Estrogenic endocrine disrupting chemicals have been shown to disrupt maternal behavior in rodents. We investigated the effects of an emerging xenoestrogen, bisphenol S (BPS), on maternal behavior and brain in CD-1 mice exposed during pregnancy and lactation (F0 generation) and in female offspring exposed during gestation and perinatal development (F1 generation). We observed different effects in F0 and F1 dams for a number of components of maternal behavior, including time on the nest, time spent on nest building, latency to retrieve pups, and latency to retrieve the entire litter. We also characterized expression of estrogen receptor a in the medial preoptic area (MPOA) and quantified tyrosine hydroxylase immunoreactive cells in the ventral tegmental area, 2 brain regions critical for maternal care. BPS-treated females in the F0 generation had a statistically significant increase in estrogen receptor a expression in the caudal subregion of the central MPOA in a dose-dependent manner. In contrast, there were no statistically significant effects of BPS on the MPOA in F1 dams or the ventral tegmental area in either generation. This work demonstrates that BPS affects maternal behavior and brain with outcomes depending on generation, dose, and postpartum period. Many studies examining effects of endocrine disrupting chemicals view the mother as a means by which offspring can be exposed during critical periods of development. Here, we demonstrate that pregnancy and lactation are vulnerable periods for the mother. We also show that developmental BPS exposure alters maternal behavior later in adulthood. Both findings have potential public health implications. (Endocrinology 158: 516-530, 2017)

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“…BPS exposure was found to alter behaviour in terms of increased anxiety and reduced interest in social interactions in rats [59,60]. Recently, BPS and BPF were also found to affect dopamine (DA) -and serotonin (5-HT)-related genes, and the neuro-steroidogenesis-related enzyme, 5α-reductase (5α-R), in the prefrontal cortex of juvenile female rats due to maternal exposure [61].…”

Section: Effect On Nervous System Development and Behaviourmentioning

confidence: 99%

The dark side of the breastfeeding: In the light of endocrine disruptors

Chemek

Nevoral

2019

Medical Journal of Cell Biology

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Breastfeeding plays an essential role in the healthy development of a newborn, but human milk is obviously compromised by pollutants from our environment. The main contaminants of human milk with endocrine-disrupting compound (EDCs) have raised concern for public and environmental health. Bisphenol A (BPA), which can leach from plastics, are among the most well-studied. Since EDs are known to cross the mammary gland barrier and BPA may accumulate in the neonate, “BPA-free” products have been introduced to the market. However, recent studies have shown that alternative bisphenols (e.g. BPS, BPF) can be detected in breast milk, have ED activities and may have developmental effects similar to BPA.

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Bisphenol A, bisphenol F and bisphenol S affect differently 5α-reductase expression and dopamine–serotonin systems in the prefrontal cortex of juvenile female rats

Cited by 103 publications

References 61 publications

Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

Bisphenol S (BPS) alters maternal behavior and brain in mice exposed during pregnancy/lactation and their daughters

The dark side of the breastfeeding: In the light of endocrine disruptors

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