Bisphenol A (BPA)-Induced Changes in the Number of Serotonin-Positive Cells in the Mucosal Layer of Porcine Small Intestine—the Preliminary Studies

Gonkowski, Sławomir

doi:10.3390/ijms21031079

Cited by 17 publications

(15 citation statements)

References 25 publications

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“…BPA caused the decrease in the number of cholinergic neurons and intramural nerves. This observation is in line with the previous studies concerning fluctuations of neurotransmitters and/or neuromodulators in the autonomic nervous system supplying the uterus and small intestine in response to the impact of BPA [ 6 , 12 , 13 , 40 ]. Moreover, the recent investigations have reported that the number of cholinergic enteric nervous structures is also reduced during various pathological and toxic stimuli [ 13 , 42 , 43 ].…”

Section: Discussionsupporting

confidence: 92%

“…Contrary to the intestine, where BPA may affect the motility, secretion, intestinal barrier, and neurochemical coding of neuronal cells and nerves in the ENS [ 12 , 13 , 40 ], knowledge about the influence of BPA on the stomach is extremely scarce. It is only acknowledged that BPA causes changes in the number of nitrergic enteric nerve cells in both types of gastric intramural plexuses [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

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Bisphenol A (BPA) Affects the Enteric Nervous System in the Porcine Stomach

Makowska

Gonkowski

2020

Animals

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Bisphenol A (BPA) is widely utilized in plastic production process all over the world. Previous studies have shown that BPA, with its similarity to estrogen, may negatively affect living organisms. It is acknowledged that BPA distorts the activity of multiple internal systems, including the nervous, reproductive, urinary, and endocrine systems. BPA also affects the gastrointestinal tract and enteric nervous system (ENS), which is placed throughout the wall from the esophagus to the rectum. Contrary to the intestine, the influence of BPA on the ENS in the stomach is still little known. This study, performed using the double immunofluorescence method, has revealed that BPA affects the number of nervous structures in the porcine gastric wall immunoreactive to vesicular acetylcholine transporter (VAChT, a marker of cholinergic neurons), substance P (SP), vasoactive intestinal polypeptide (VIP), galanin (GAL) and cocaine- and amphetamine-regulated transcript peptide (CART). The character and severity of noted alterations depended on the part of the ENS, the BPA dose, and the type of neuronal substance. Administration of BPA resulted in an increase in the number of nervous structures containing SP, GAL, and/or CART, and a decrease in the number of cholinergic neurons in all parts of the gastric wall. The number of VIP-positive nervous structures increased in the enteric myenteric ganglia, along with the muscular and mucosal layers, whilst it decreased in the submucous ganglia. The exact mechanism of noted changes was not absolutely obvious, but they were probably related to the neuroprotective and adaptive processes constituting the response to the impact of BPA.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Bisphenol A (BPA) Affects the Enteric Nervous System in the Porcine Stomach

Makowska

Gonkowski

2020

Animals

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“…Therefore, 60 observation fields were evaluated for each sample from each animal. The obtained data were pooled and analysed as comparison of mean value [ 31 ]. Statistical analysis was performed using Student’s t-test (GraphPad Prism v. 3.0, GraphPad Software Inc., San Diego, CA, USA).…”

Section: Methodsmentioning

confidence: 99%

Distinct Pattern of NPY in Gastro–Entero–Pancreatic System of Goat Kids Fed with a New Standardized Red Orange and Lemon Extract (RLE)

Felice

Giaquinto

Damiano

et al. 2021

Animals

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The use of natural compounds as feed additive is also increasing in farm animals, thanks to the beneficial effect on both animals and consumers health. Here, we questioned whether natural extracts, such as red orange and lemon extract (RLE) rich in flavanones, anthocyanins, and other polyphenols, used as feed additives could display an effect on the neuropeptide Y (NPY) in the gastro–entero–pancreatic tract of goat kids. NPY is one of the most abundant neuropeptides in mammals, known for its orexigenic role although it is involved in many central and peripheral functions. We carried out immunohistochemical analyses on samples of abomasum, duodenum and pancreas collected from two experimental groups: one fed with standard diet and one with standard diet + RLE. For the first time we document NPY distribution in the abomasum, duodenum and pancreas of goats and observe the highest number of NPY positive cells in neuroendocrine cells of duodenum. Remarkably, upon RLE feed supplementation, NPY immunoreactive cells increased significantly in abomasal epithelium and pancreatic islets but not in duodenum, likely due to pH variation of abomasum and duodenum. Our observations represent a baseline for future studies on the interaction between neuropeptides and polyphenols, used as feed additive.

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“…It recalls that 5-HT can be seen as an orchestrator of metabolism and cell interaction. Modification of 5-HT function should draw specific attention as indicated by Slawomir Gonkowski [4]. In his study performed in the porcine intestine, he found that the exposition of pigs to Bisphenol A, a substance used in the production of plastics, enhances the number of 5-HT cells along with the mucosal layer of the duodenum, jejunum, and ileum.…”

Section: Introductionmentioning

confidence: 99%

Serotonin in Health and Disease

Deurwaerdère

Giovanni

2020

IJMS

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The International Journal of Molecular Sciences Special Issue “Serotonin in health and diseases” covers several aspects of the multiple and still mysterious functions of serotonin (5-hydroxytryptamine; 5-HT). 5-HT is neurotransmitter acting in the central nervous system (CNS), blood factor, and neurohormone controlling the function of several peripheral organs. Beyond its widespread implication in physiology, the 5-HT system is involved in numerous diseases of the CNS (e.g., depression, anxiety, schizophrenia, obsessive-compulsive disorders, addiction, Parkinson’s disease) and peripheral organs (e.g., gastrointestinal disorders, cardiac arrhythmia, hypertension). The Special Issue includes 14 articles dealing with molecular and cellular effects of 5-HT in periphery and CNS, from functional aspects in lower animals to clinical practices. Beyond physiology, the Special Issue also covers the influence of 5-HT and its receptors in the mechanism of action of psychoactive molecules including antipsychotics, antidepressants, and drug of abuse. The recent progress made on the function and dysfunction of the 5-HT system will certainly increase the understanding of the widespread role of 5-HT ultimately leading to better apprehend its targeting in human diseases.

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Bisphenol A (BPA)-Induced Changes in the Number of Serotonin-Positive Cells in the Mucosal Layer of Porcine Small Intestine—the Preliminary Studies

Cited by 17 publications

References 25 publications

Bisphenol A (BPA) Affects the Enteric Nervous System in the Porcine Stomach

Bisphenol A (BPA) Affects the Enteric Nervous System in the Porcine Stomach

Distinct Pattern of NPY in Gastro–Entero–Pancreatic System of Goat Kids Fed with a New Standardized Red Orange and Lemon Extract (RLE)

Serotonin in Health and Disease

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