“…Bisphenol A (BPA), which is made by Phenol and acetone [2], is an industrially important chemical that is used as a raw material in the manufacture of many products such as engineering plastics (e.g., epoxy resins/ polycarbonate plastics), food cans (i.e., lacquer coatings), and dental composites/sealants [3]. Extensive evidence indicates that BPA induces feminization during gonadal ontogeny of fishes [4], reptiles [5], birds [6], and human [7,8], and it is identified as an endocrine disruptor and leads to carcinogenesis [9]. Biology is exposed to ubiquitous BPA Though its hazardous effects, more than 5 million metric tons of BPA was produced in 2011 and was mainly used in East Asia (Korea, China and Japan), and kept increasing year by year [10,11].…”