Bisphenol A Exposure Causes Meiotic Aneuploidy in the Female Mouse

Abstract

Both the initial inadvertent exposure and subsequent experimental studies suggest that BPA is a potent meiotic aneugen. Specifically, in the female mouse, short-term, low-dose exposure during the final stages of oocyte growth is sufficient to elicit detectable meiotic effects. These results provide the first unequivocal link between mammalian meiotic aneuploidy and an accidental environmental exposure and suggest that the oocyte and its meiotic spindle will provide a sensitive assay system for the study of reproductive toxins.

Aneuploid sperm formation in rainbow trout exposed to the environmental estrogen 17α-ethynylestradiol

“…This study indicates that sperm chromosome damage leads to a pattern of embryo death similar to that observed when male parents are exposed to EE2 (31,42). Additionally, evidence exists that exposure of female mice to low levels of BPA and of maturing oocytes to supraphysiological levels of 2-methoxyestradiol, causes increases in aneuploid oocyte formation (46,47), although the BPA studies could not be reproduced by another study (40). These observations led us to propose that exposure of sexually maturing male rainbow trout to EE2 results in aneuploid sperm formation, which causes a significant proportion of embryos to die shortly after fertilization.…”

Sirt2‐BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality

“…Chromosome spread was conducted as described previously (Hunt et al., 2003). Briefly, MII oocytes were exposed to Tyrode's buffer (pH 2.5) for about 30 s at 37°C to remove zona pellucida.…”

4-Nonylphenol, bisphenol-A and triclosan levels in human urine of children and students in China, and the effects of drinking these bottled materials on the levels

“…toothpaste, cosmetics, skin care creams and lotions, soaps and dental products) (Jones et al, 2000;McAvoy et al, 2002;Tsai et al, 2008). These chemicals are known as endocrine disrupting compounds that may cause adverse effects on wildlife as well as human beings (Crain et al, 2007;Hunt et al, 2003;Yang et al, 2008;Ying, 2006).…”