Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women

Yang, Yoon Jung; Hong, Yun Chul; Oh, Se Young; Park, Min Seon; Kim, Ho; Leem, Jong Han; Ha, Eun Hee

doi:10.1016/j.envres.2009.04.014

Cited by 199 publications

(150 citation statements)

References 29 publications

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“…Table 1 summarizes the studies and their findings. Thirteen studies were cross-sectional (62)(63)(64)67,68,(71)(72)(73)(75)(76)(77)(78) , two were case-control (65,70) and two were prospective cohort studies (66,74) , but all data analyses were crosssectional. One of the cohort studies did prospectively evaluate rate of weight change, but only evaluated the association between BMI and urinary BPA levels at baseline (74) .…”

Section: Resultsmentioning

confidence: 99%

“…For six of the articles, body composition (BMI, WC and/or weight) was the primary outcome of interest (62)(63)(64)67,71,74) . Seven studies included only women (65,67,69,73,74,77,78) , nine of the studies were in general adult populations (62)(63)(64)66,67,70,71,75,76) , one study included men and women ≥60 years (72) and another included only 70-year-old men and women (79) .…”

Section: Resultsmentioning

confidence: 99%

“…Six studies measured serum BPA levels; four using a competitive ELISA (65,68,73,78) , one using HPLC paired with an electrochemical detector (77) and one using LC and tandem MS (LC-MS/MS) (79) . Ten studies measured total BPA in spot urine samples (62)(63)(64)67,(70)(71)(72)(74)(75)(76) , one study used the geometric mean for two spot samples collected during the same in vitro fertilization cycle (69) and one study measured total BPA in a 24 h urine sample (66) . Urinary BPA levels were measured using GC-MS (63) and/or HPLC and tandem MS (HPLC-MS/MS) (62)(63)(64)66,67,71,72,74) .…”

Section: Resultsmentioning

confidence: 99%

“…Urinary BPA levels are much higher and consist largely of conjugated BPA, which can only be formed in vivo, thus acting as a marker for ruling out contamination by extraneous sources (88) . In fourteen of the studies (64,(66)(67)(68)(69)(70)(71)(72)(73)(75)(76)(77)(78)(79) , including five of six studies that measured serum BPA levels, the manuscripts lacked sufficiently detailed information to determine whether BPA-free materials were used to collect, process and store biospecimens. Failure to use BPA-free laboratory materials could lead to sample contamination and inaccurate BPA measurements, particularly with serum measurements (64,65,67,68,73,88) .…”

Section: Discussionmentioning

confidence: 99%

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Bisphenol A exposure and associations with obesity among adults: a critical review

Oppeneer

Robien

2014

Public Health Nutr.

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Objective: To review the literature on bisphenol A (BPA) exposure and obesity in human populations. Design: Systematic review of the literature via searches of PubMed, EMBASE, Web of Science and reference lists for articles published to 1 August 2014. Setting: China, Italy, Japan, Republic of Korea, Sweden, UK, USA. Subjects: Adults (≥18 years). Results: Eighteen articles were identified and included in the review. Twelve studies included secondary evaluations of BPA exposure and BMI, and six studies evaluated body composition as the primary outcome. All analyses were crosssectional and no study included in the review received a positive quality rating (twelve negative, six neutral). Eight studies observed a statistically significant positive association between urinary or serum BPA levels and BMI, and ten studies observed no association. Studies where BMI was a primary outcome and studies of neutral quality were more likely to observe an association. Conclusions: Study results are conflicting and significant methodological issues limit the ability to draw conclusions from these studies. Prospective studies that measure BPA exposure and changes in body weight and composition are needed to establish temporality, causality and the direction of any observed associations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Bisphenol A exposure and associations with obesity among adults: a critical review

Oppeneer

Robien

2014

Public Health Nutr.

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“…To our knowledge, this is the only published study that completely failed to detect or measure any form of BPA in urine samples from environmentally exposed individuals. Volkel et al (2005) used HPLC-MS/MS; this is the same technique that was used in several other studies in which unconjugated and conjugated BPA were detected in urine Hong et al 2009;Mahalingaiah et al 2008;Nepomnaschy et al 2009;Teitelbaum et al 2008;Wolff et al 2007;Yang YJ et al 2009;Ye et al 2009a). Why did Volkel et al (2005) not detect any form of BPA?…”

Section: Exposure Assessment From Urinary Measures Of Bpamentioning

confidence: 99%

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

Vandenberg

Chahoud

Heindel³

et al. 2012

Ciênc. saúde coletiva

333

331

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Estudos de biomonitoração do sistema urinário, circulatório e tecidos indicam grande exposição ao Bisfenol A Resumo Bisfenol A (BPA) é um dos produtos quí-micos mais produzido em todo o mundo, e a exposição humana a ele é considerada onipresente. Assim, há preocupações de que a quantidade de BPA para o qual os seres humanos estão expostos podem causar efeitos adversos à saúde. Nós examinamos muitas possibilidades sobre o porquê estudos de biomonitorização e toxicocinética podem chegar a conclusões aparentemente conflitantes. Mais de 80 estudos publicados de biomonitorização humana que mediram a concentração de BPA em tecidos humanos, urina, sangue e outros fluidos, juntamente com dois estudos de toxicocinéti-ca do metabolismo humano BPA foram examinados. BPA não conjugado foi detectado no sangue (nonanogramas por mililitro gama), e BPA conjugado foi detectado na grande maioria das amostras de urina. Em contraste, estudos de toxico-cinética propuseram que os seres humanos não são internamente expostos ao BPA. Dados disponíveis de estudos de biomonitorização indicam que a população em geral está exposta ao BPA e em risco de exposição interna ao BPA não conjugado. Os dois estudos de toxicocinética, que sugeriram a exposição humana ao BPA é insignificante, têm deficiências significativas e estão diretamente refutados por outros estudos e, portanto não são confiáveis para fins de avaliação de risco. Palavras-chave Disruptor endócrino, Exposição humana, Modelo PBPK/PBTK, Gravidez, Avaliação de risco, Toxicocinética Abstract Bisphenol A (BPA) is one of the highest-volume chemicals produced worldwide, and human exposure to BPA is thought to be ubiquitous. Thus, there are concerns that the amount of BPA to which humans are exposed may cause adverse health effects. We examined many possibilities for why biomonitoring and toxicokinetic studies could come to seemingly conflicting conclusions. More than 80 published human biomonitoring studies that measured BPA concentrations in human tissues, urine, blood, and other fluids, along with two toxicokinetic studies of human BPA metabolism were examined. Unconjugated BPA was routinely detected in blood (in the nanograms per milliliter range), and conjugated BPA was routinely detected in the vast majority of urine samples (also in the nanograms per milliliter range). In stark contrast, toxicokinetic studies proposed that humans are not internally exposed to BPA. Available data from biomonitoring studies clearly indicate that the general population is exposed to BPA and is at risk from internal exposure to unconjugated BPA. The two toxicokinetic studies that suggested human BPA exposure is negligible have significant deficiencies, are directly contradicted by hypothesis-driven studies, and are therefore not reliable for risk assessment purposes.

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Association of Exposure to Phthalate Metabolites With Sex Hormones, Obesity, and Metabolic Syndrome in US Women

et al. 2022

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ImportanceObesity and metabolic syndrome are highly prevalent among the US population and are associated with the dysregulation of sex hormones. An increase in obesity and metabolic syndrome may also be associated with exposure to phthalates. The association of exposure to phthalate metabolites with sex hormones and metabolic health has been understudied in the female population.ObjectiveTo evaluate the association between exposure to common phthalate metabolites with total testosterone (TT) levels, sex hormone–binding globulin (SHBG) levels, obesity, and metabolic syndrome among women.Design, Setting, and ParticipantsThis cross-sectional study used data collected from the National Health and Nutrition Examination Survey during 2013 to 2016. Female participants aged 15 years or older with urinary profiles containing common phthalate metabolites were included in this study. Statistical analyses were performed from March 15, 2021, to April 30, 2022.ExposuresUrinary concentrations of phthalate metabolites were classified into tertiles, and the lowest tertile was used as a reference category. The concentrations of phthalate metabolites and their composite scores based on clustering were also used in the analysis.Main Outcomes and MeasuresSerum concentrations of TT and SHBG were dichotomized into high TT levels (&gt;46 ng/dL [to convert to nanomoles per liter, multiply by 0.0347] for age &lt;50 years and &gt;32 ng/dL for age ≥50 years) and low SHBG levels (&lt;2.85 μg/mL [to convert to nanomoles per liter, multiply by 10.53]) as established for the female population. Obesity was defined as a body mass index of 30 or more (calculated as weight in kilograms divided by height in meters squared), and metabolic syndrome was defined using the National Cholesterol Education Program criteria. The serum concentrations of TT and SHBG were also included in the validation analyses. Modified Poisson models were used to estimate the adjusted relative risk (RR) with 95% CIs for the associations.ResultsAmong the 2004 women included in this study, the mean (SD) age was 46.6 (18.5) years (14.7% Hispanic participants, 62.7% non-Hispanic White participants, and 13.2% non-Hispanic Black participants; 17.4% of participants were born outside the US [weighted percentages]; 230 (11.8%) had high TT levels, 210 (10.4%) had low SHBG levels, 825 (39.8%) had obesity, and 965 (45.5%) had metabolic syndrome (weighted percentages). Of the 13 phthalate metabolites, 8 had the highest tertile level greater than 6.2 ng/mL (range, 0.5-75.2 ng/mL). High levels of exposure to mono(2-ethyl-5-carboxypentyl) phthalate (RR, 1.84 [95% CI, 1.33-2.54]), mono(2-ethyl-5-oxohexyl) phthalate (RR, 1.77 [95% CI, 1.21-2.59]), mono(2-ethyl-5-hydroxyhexyl) phthalate (RR, 1.94 [95% CI, 1.34-2.81]), and monobenzyl phthalate (RR, 1.75 [95% CI, 1.21-2.54]) were associated with low SHBG levels but not with high TT levels. High levels of exposure to some of these metabolites were also associated with obesity and metabolic syndrome. Most associations were specific to premenopausal or postmenopausal women.Conclusions and RelevanceIn this cross-sectional study, exposure to certain phthalate metabolites could be associated with low SHBG levels, obesity, and metabolic syndrome depending on menopausal status.

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Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women

Cited by 199 publications

References 29 publications

Bisphenol A exposure and associations with obesity among adults: a critical review

Bisphenol A exposure and associations with obesity among adults: a critical review

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

Association of Exposure to Phthalate Metabolites With Sex Hormones, Obesity, and Metabolic Syndrome in US Women

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