Bisphenol A exposure is involved in the development of Parkinson like disease in Drosophila melanogaster

Musachio, Elize Aparecida Santos; Araújo, Stífani Machado; Bortolotto, Vandreza Cardoso; Couto, Shanda de Freitas; Dahleh, Mustafa Munir Mustafa; Poetini, Márcia Rósula; Jardim, Eliana Fernandes; Meichtry, Luana Barreto; Ramborger, Bruna Piaia; Roehrs, Rafael; Guerra, Gustavo Petri; Prigol, Marina

doi:10.1016/j.fct.2020.111128

Cited by 42 publications

(16 citation statements)

References 46 publications

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“…Such changes were even observed in offspring whose mothers were subjected to one dose of BPA in perinatal period [15]. Some previous studies have reported that BPA administration raises the risk of occurrence of neurodegenerative diseases, in particular Parkinson's and Alzheimer's diseases [16,17].…”

Section: Introductionmentioning

confidence: 94%

Bisphenol A (BPA) Affects the Enteric Nervous System in the Porcine Stomach

Makowska

Gonkowski

2020

Animals

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Bisphenol A (BPA) is widely utilized in plastic production process all over the world. Previous studies have shown that BPA, with its similarity to estrogen, may negatively affect living organisms. It is acknowledged that BPA distorts the activity of multiple internal systems, including the nervous, reproductive, urinary, and endocrine systems. BPA also affects the gastrointestinal tract and enteric nervous system (ENS), which is placed throughout the wall from the esophagus to the rectum. Contrary to the intestine, the influence of BPA on the ENS in the stomach is still little known. This study, performed using the double immunofluorescence method, has revealed that BPA affects the number of nervous structures in the porcine gastric wall immunoreactive to vesicular acetylcholine transporter (VAChT, a marker of cholinergic neurons), substance P (SP), vasoactive intestinal polypeptide (VIP), galanin (GAL) and cocaine- and amphetamine-regulated transcript peptide (CART). The character and severity of noted alterations depended on the part of the ENS, the BPA dose, and the type of neuronal substance. Administration of BPA resulted in an increase in the number of nervous structures containing SP, GAL, and/or CART, and a decrease in the number of cholinergic neurons in all parts of the gastric wall. The number of VIP-positive nervous structures increased in the enteric myenteric ganglia, along with the muscular and mucosal layers, whilst it decreased in the submucous ganglia. The exact mechanism of noted changes was not absolutely obvious, but they were probably related to the neuroprotective and adaptive processes constituting the response to the impact of BPA.

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Section: Introductionmentioning

confidence: 94%

Bisphenol A (BPA) Affects the Enteric Nervous System in the Porcine Stomach

Makowska

Gonkowski

2020

Animals

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“…Behavioral tests are also extremely important tools for assessing the toxicological potential of compounds (Araujo et al 2015, Musachio et al 2020. This is because behaviors serve as a guide to understanding the mechanisms behind the results found (Belovicova et al 2017, Hånell & Marklund 2014.…”

Section: Discussionmentioning

confidence: 99%

“…The open field test was performed as described by Connolly (1966), with modifications by Musachio et al (2020). Six flies from each repetition (18 flies per treatment) were randomly selected among the live flies, and after being immobilized on ice, each one was placed on a Petri dish divided into squares measuring 1 cm 2 .…”

Section: Open Field Testmentioning

confidence: 99%

Insecticidal activity of the organotellurium 2-Phenylethynyl-Butyltellurium on the Drosophila melanogaster model

Bittencourt

Souza

2023

An. Acad. Bras. Ciênc.

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2-Phenylethynyl-Butyltellurium (PEBT) is a synthetic organotellurium compound that has shown various pharmacological properties on mammals without any signs of toxicity, but its effects on insects have not been reported before. Therefore, the aim of this study was to assess whether acute exposure to PEBT would promote an insecticidal effect against Drosophila melanogaster. The flies were exposed to three concentrations of PEBT (0.325 µmol L -1 , 1.300 µmol L -1 , and 5.200 µmol L -1 ) and a control solution (vehicle), using 450 flies per treatment (three repetitions of 150 flies), for 48 hours. Negative geotaxis and open field tests were performed (in vivo) after 24 and 48h, and acetylcholinesterase (AChE) activity was assessed (ex vivo) after 48h. Also, the mortality rate, 50% Lethal Concentration (LC 50 ), 80% Lethal Concentration (LC 80 ), and 95% Lethal Concentration (LC 95 ) were calculated. Our results show that PEBT presented insecticidal activity against Drosophila melanogaster at all tested concentrations, which caused locomotor impairment and increased acetylcholinesterase activity in the flies' heads.

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“…BPA is excreted from the urine in this form [34] . Drosophila melanogaster exposed to 1 mmol/L BPA showed PD-like hypokinesia and decreased acetylcholinesterase (AChE) activity and dopamine secretion [35] . Dopaminergic neurons decreased in the ventral midbrains of Rhesus monkeys exposed to BPA at the same concentration in the human body in the last 2 months of pregnancy, suggesting that fetal exposure to low concentrations of BPA affected the development of dopaminergic neurons in the midbrain.…”

Section: Possible Effects Of Bpa On Neurodegenerative Diseasesmentioning

confidence: 99%

“…In rats with prenatal exposure to BPA, beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), nuclear factor kappa B (NF-kB), and tumor necrosis factor-a (TNF-a) messenger RNA (mRNA) were up-regulated, and increased BACE1 and NF-kB protein were also detected at the same time. BACE1 is a key Both sexes [30,31] : BACE1 ↑, NF-kB ↑, TNF-a ↑ Male [32] : APP ↑, p-tau ↑ Male [33] : p-JNK ↑, p-ERK ↑, PP2A ↓ PD Tremor Rigidity Bradykinesia Postural instability Decreased dopamine secretion Human [34] : Glucuronide-acidified BPA ↓ Drosophila melanogaster [35] : AChE activity ↓, dopamine secretion ↓ Rhesus monkeys [17] : Dopaminergic neurons ↓ enzyme involved in the proteolysis of amyloid precursor protein (APP) and is closely related to AD. [30,31] NF-kB and TNF-a play important roles in the inflammation, implying that prenatal BPA exposure may increase AD risk.…”

Section: Possible Effects Of Bpa On Neurodegenerative Diseasesmentioning

confidence: 99%

Effects of bisphenol A and bisphenol analogs on the nervous system

Sang

Zhang

et al. 2023

Chinese Medical Journal

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Estrogen impacts neural development; meanwhile, it has a protective effect on the brain. Bisphenols, primarily bisphenol A (BPA), can exert estrogen-like or estrogen-interfering effects by binding with estrogen receptors. Extensive studies have suggested that neurobehavioral problems, such as anxiety and depression, can be caused by exposure to BPA during neural development.Increasing attention has been paid to the effects on learning and memory of BPA exposure at different developmental stages and in adulthood. Further research is required to elucidate whether BPA increases the risk of neurodegenerative diseases and the underlying mechanisms, as well as to assess whether BPA analogs, such as bisphenol S and bisphenol F, influence the nervous system.

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Bisphenol A exposure is involved in the development of Parkinson like disease in Drosophila melanogaster

Cited by 42 publications

References 46 publications

Bisphenol A (BPA) Affects the Enteric Nervous System in the Porcine Stomach

Bisphenol A (BPA) Affects the Enteric Nervous System in the Porcine Stomach

Insecticidal activity of the organotellurium 2-Phenylethynyl-Butyltellurium on the Drosophila melanogaster model

Effects of bisphenol A and bisphenol analogs on the nervous system

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