Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells

Okazaki, Hiroyuki; Takeda, Shuso; Kakizoe, Kazuhiro; Taniguchi, Aya; Tokuyasu, Miki; Himeno, Taichi; Ishii, Hiroyuki; Kohro-Ikeda, Eriko; Haraguchi, Koichi; Watanabe, Kazuhito; Aramaki, Hironori

doi:10.1248/bpb.b17-00427

Cited by 22 publications

(17 citation statements)

References 30 publications

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“…As the number of chemicals classified as EDCs is increasing, EDCs are being linked with long-term health consequences. Animal models and human cohorts have associated increasing exposure to EDCs with decreased fertility, altered thyroid hormone levels, and increased risk of cancer in people directly exposed, as well as increased risk of adverse health outcomes in the children of those that were directly exposed [5][6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Exposure to polybrominated biphenyl (PBB) associates with genome-wide DNA methylation differences in peripheral blood

et al. 2019

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In 1973, Michigan residents were exposed to polybrominated biphenyl (PBB) when it was accidentally added to farm animal feed. Highly exposed individuals and their children have experienced endocrine-related health problems, though the underlying mechanism behind these remains unknown. We investigated whether PBB exposure is associated with variation in DNA methylation in peripheral blood samples from 658 participants of the Michigan PBB registry using the MethylationEPIC BeadChip, as well as investigated what the potential function of the affected regions are and whether these epigenetic marks are known to associate with endocrine system pathways. After multiple test correction (FDR <0.05), 1890 CpG sites associated with total PBB levels. These CpGs were not enriched in any particular biological pathway, but were enriched in enhancer and insulator regions, and depleted in regions near the transcription start site or in CpG islands (p < 0.05). They were also more likely to be in ARNT and ESR2 transcription factor binding sites (p = 3.27e-23 and p = 1.62e-6, respectively), and there was significant overlap between CpGs associated with PBB and CpGs associated with estrogen (p < 2.2e-16). PBBassociated CpGs were also enriched for CpGs known to be associated with gene expression in blood (eQTMs) (p < 0.05). These eQTMs were enriched for pathways related to immune function and endocrine-related autoimmune disease (FDR <0.05). These results indicate that exposure to PBB is associated with differences in epigenetic marks that suggest that it is acting similarly to estrogen and is associated with dysregulated immune system pathways. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Exposure to polybrominated biphenyl (PBB) associates with genome-wide DNA methylation differences in peripheral blood

et al. 2019

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“…Many studies, however, also found their potential negative effects on human health. They have been detected in human biological samples and it has been demonstrated that Bisphenols (BPA, BPB, BPS and BPAF) have exerted a positive effect on estrogen receptor a-mediated transcriptional ac-tivation in vitro studies [3]. Using the MCF-7 breast cancer cell line, the influence of four bisphenols on estrogen signaling was studied.…”

Section: Bisphenol a And Carcinogenesismentioning

confidence: 99%

“…The main sources of exposure to BPA are food packaging, dust, dental materials, medical equipment, thermal paper, toys and articles for children and babies. Small amounts of BPA can be released from artificial materials, polycarbonate or coatings made of resin that form part of food packaging (plastic bottles, reusable food containers, baby bottles, water pipes) and get into food and drink [1][2][3]. This may occur as a result of damage to the plastic or coating made of resin, as well as during the decomposition of the product containing BPA under the influence of high temperature.…”

Section: Introductionmentioning

confidence: 99%

“…As a result, the washed out BPA is found in streams, rivers and drinking water, so the main source of its exposure is food and drink. One of the most important sources of dietary exposure to BPA is food in cans, but it can also be present in fresh food, such as meat, milk or eggs, when animals are bred in contaminated areas, and plants watered with contaminated water [1][2][3]. Biomonitoring studies have shown that the urine of most people living in industrialized countries contains measurable BPA and its metabolites: glucuronide and BPA sulfate [1].…”

Section: Introductionmentioning

confidence: 99%

“…More and more evidence indicates that substances disrupting endocrine function, including BPA, can act as carcinogens and increase susceptibility to neoplasms. So far, however, the role of BPA has not been established, and its influence on the occurrence and development of tumors remains unknown [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

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The role of bisphenol A in the carcinogenesis process

Chludzińska¹,

Modzelewska²,

Koda³

et al. 2018

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Bisphenol A (BPA), one of the most common endocrine disrupting chemicals, is a carbon-based synthetic compound used in the production of water bottles, cans, food packaging, dental materials, medical equipment, thermal paper, toys and articles for children. Bisphenol A has been associated with serious health effects in humans. It elicits several disorders and plays a role in the pathogenesis of several tumors such as breast, ovarian, prostate and colorectal cancer. The aim of the research is to review the latest literature assessing participation of BPA in the process of neoplasia. There is not much research on this subject and the role of BPA in the carcinogenesis is still not understood. The present review summarizes the current knowledge of the role of BPA in carcinogenesis. Streszczenie Bisfenol A (BPA) jest jednym z najczęściej występujących organicznych związków chemicznych, które zaburzają gospodarkę hormonalną. Stosowany jest w produkcji tworzyw sztucznych, plastikowych butelek, puszek, opakowań do żywności, materiałów dentystycznych, sprzętu medycznego, papieru termicznego, zabawek i artykułów dla dzieci. Bisfenol A powoduje poważne skutki dla zdrowia ludzi. Wywołuje zaburzenia zdrowotne i odgrywa ważną rolę w patogenezie wielu nowotworów, takich jak rak sutka, jajnika, gruczołu krokowego, jelita grubego. Celem badań jest przegląd najnowszego piśmiennictwa dotyczącego udziału bisfenolu A w procesie nowotworzenia. Do tej pory nie przeprowadzono wystarczającej liczby takich badań, a rola bisfenolu A w procesie kancerogenezy wciąż nie została zrozumiana. W niniejszym przeglądzie podsumowano aktualną wiedzę na temat roli bisfenolu A w kancerogenezie.

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Fluorene-9-bisphenol inhibits epithelial-mesenchymal transition of human endometrial cancer Ishikawa cells by repressing TGF-β signaling pathway

Wang

Zhuang

et al. 2019

Environ Sci Pollut Res

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Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells

Cited by 22 publications

References 30 publications

Exposure to polybrominated biphenyl (PBB) associates with genome-wide DNA methylation differences in peripheral blood

Exposure to polybrominated biphenyl (PBB) associates with genome-wide DNA methylation differences in peripheral blood

The role of bisphenol A in the carcinogenesis process

Fluorene-9-bisphenol inhibits epithelial-mesenchymal transition of human endometrial cancer Ishikawa cells by repressing TGF-β signaling pathway

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