Bisphenol C Induces Cardiac Developmental Defects by Disrupting m6A Homeostasis
Kunhui Su,
Jinfeng Liu,
Jiafeng Chen
et al.
Abstract:Bisphenol A (BPA) is a commonly used plastic additive. Since BPA has been banned in maternal and infant food containers in many countries, BPA substitutes have been widely introduced to replace it. By systematically assessing the potential developmental toxicity of BPA substitutes, we observed that the 41−150 nM in vivo BPC exposure (around the reported concentration detected in infant urine: 6−186 nM) induced cardiac defects in zebrafish. Mechanistically, BPC disrupted m 6 A homeostasis by downregulation of t… Show more
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