Bisphenol Compounds on Human Reproduction Health

Abstract

Bisphenol-A (BPA) is widely used in the plastic industry, and it is one of the well-studied endocrine disrupting chemicals (EDCs). Growing evidence raised the concern of BPA having weak estrogenic activity on human health including female reproductive functions and diseases. Serum BPA level is also associated with pregnancy loss, reproductive tract diseases and infertility. In fact, several countries restricted the use of BPA, and therefore substitutes which share similar chemical and physical properties with BPA were used. However, the effects of these bisphenols (e.g. bisphenol-F (BPF) and bisphenol-S (BPS)) on human reproductive health have not been fully investigated, and this mini-review summarized the recent data of these bisphenols on human reproductive health, and raise the concern on the safety and transgenerational effect of these bisphenols in humans.