Bisphenol A vascular toxicity: Protective effect of Vitis vinifera (grape) seed extract and resveratrol

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The mechanisms of bisphenol‐A (BPA)‐induced metabolic syndrome as well as the protective role of grape seed extract (GSE) and resveratrol were investigated. Rats were treated with BPA (0 and 35 mg·kg−1·day−1, gavage) plus resveratrol (25, 50, and 100 mg·kg−1·day−1, i.p.) or GSE (3, 6, 12 mg·kg−1·day−1, i.p.) or vitamin E (200 IU/kg/every other day, i.p.). After 2 months, mean systolic blood pressure, serum lipid profile, glycaemia, and fat index were examined. By enzyme‐linked immunosorbent assay, the serum concentrations of insulin, leptin, adiponectin, and paraoxonase 1, and by real‐time polymerase chain reaction as well as western blotting, key liver elements in cholesterol hemostasis (LDLR, CYP7A1, ABCG5 and 8) and insulin signaling (p‐Akt/Akt and p‐PI3K/PI3K) were measured. BPA increased mean systolic blood pressure, total cholesterol, and low‐density lipoprotein cholesterol and reduced paraoxonase1 and the hepatic expression of both ABCG5 and ABCG8. It increased the body fat index, leptin, adiponectin, insulin, and glycaemia level and decreased the hepatic protein expression of p‐Akt/Akt and p‐PI3K/PI3k. GSE, resveratrol, or vitamin E coadministration along with BPA restored the detrimental effects of BPA in some levels. Herein, the predisposing effects of BPA‐induced metabolic syndrome were restored by GSE and resveratrol, linked to the regulation of insulin signaling, ABCG8 expression, and their antioxidant properties.

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Grape Seed Extract Preparationmentioning

confidence: 99%

Section: The Effects On the Mean Systolic Blood Pressurementioning

confidence: 99%

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Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol‐A‐induced metabolic syndrome: Biochemical and molecular evidences

Rameshrad

Razavi

Imenshahidi

et al. 2019

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Evaluation of green tea extract and epigallocatechin gallate effects on bisphenol A‐induced vascular toxicity in isolated rat aorta and cytotoxicity in human umbilical vein endothelial cells

Mohsenzadeh

Razavi

Imenshahidi

et al. 2020

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This study was designed to assess bisphenol A (BPA)‐induced vascular toxicity, the effectiveness of green tea extract and epigallocatechin gallate (EGCG) against BPA toxicity, and possible underlying mechanisms. In isolated rat aorta, contractile and relaxant responses as well as malondialdehyde levels were evaluated. Cell viability and effects on the protein levels of apoptotic (bax, bcl2, and caspase‐3), autophagic (LC3), and cell adhesion molecules were calculated using the MTT method and western blotting in human umbilical vein endothelial cells (HUVECs). BPA increased aorta MDA levels (p < .0001) and decreased vascular responses to KCl [20 and 40 mM (p < .0001), 80 mM (p < .001)], phenylephrine [10−8, 10−6, and 10−5 M (p < .001), 10−7 and 10−4 M (p < .0001)], and acetylcholine [10−6 M (p < .01), 10−5 and 10−4 M (p < .0001)]. In HUVECs, BPA enhanced the levels of LC3A/B, bax/bcl2 ratio, cleaved caspase‐3, and vascular cell adhesion molecule‐1. Green tea extract, EGCG, and vitamin E co‐treatment with BPA diminished the toxic effects of BPA. These findings provide evidence that green tea extract and EGCG possess beneficial effects in preventing BPA‐induced vascular toxicity through increasing the antioxidant activities and the regulation of signaling pathways.

Preventing contrast‐induced nephropathy (CIN) with herbal medicines: A review

Boozari

Hosseinzadeh

2020

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Objectives: Currently, the use of iodinated contrast media in diagnostic imaging has been increased in clinical medicine. Contrast-induced nephropathy (CIN) is an important adverse effect of contrast media injection. According to the significant role of oxidative stress in the pathophysiology of CIN, different herbal antioxidants have been used for the prevention of nephropathy in different studies. In this review, we discussed the preventive effects of herbal medicine and natural products against CIN. Methods: We searched the electronic databases or search engines including PubMed, Scopus, ISI, Google Scholar with search terms such as "Contrast-induced nephropathy" and "Herbal medicine," "Contrast acute kidney injury" AND "natural products" and similar headings such as plant and extract. Results: Known medicinal plants and active ingredients such as green tea, ginger, garlic, silymarin, curcumin, resveratrol, and thymoquinone have been examined for prophylactic effects or treatment of contrast media nephropathy. Conclusion: Herbal medicines have promising effects in the laboratory-based studies for the prevention and/or treatment of CIN. However, more practical and completed clinical trials are needed to investigate the clinical benefits of natural products against CIN.