Bisphosphonates Incorporated on a Ca-P Biomimetic Coating Produced by a Sodium Silicate Based Methodology Stimulate Osteoblastic Activity

Abstract

In the present study sodium clodronate, a well known therapeutic agent from the family of bisphosphonates (BP) was incorporated in an apatite coating, previously formed on the surface of a starch based biomaterial by a sodium silicate methodology, as a strategy to develop a site-specific drug delivery system for bone tissue regeneration. The effects on the resulting apatite coatings were evaluated in terms of morphology, chemistry and structure. As a preliminary approach, this first study aimed at evaluating also the effects of this BP on the viability, growth and function of a human osteoblast cell line, since there is still little information available on the interaction between BPs and this type of cells.

Influence of chemical compositions on the properties of random and multiblock sulfonated poly(arylene ether sulfone)‐based proton‐exchange membranes

“…Aliquots of 50 μL of each solution were added to the coated disks left for 3 h, followed by drying at 60°C. This procedure has been previously reported elsewhere 49. The effective concentration of the BP in the coated samples is approximately as follows: 0.004, 0.02, 0.5, and 1 mg/cm 2 .…”