Bivariate and Multivariate Spectrophotometric Methods for Determination of Ezetimibe with Kinetic Study of Its Alkaline Degradation

Abstract

The first study concerned with the determination of ezetimibe EZE in presence of its alkaline degradation product were developed and validated using different chemometric techniques [bivariate, classical least square (CLS), and principle component regression (PCR), partial least square (PLS)], with kinetic study and calculation of half-life time and activation energy which essential for quality control of its product. Application of the suggested techniques were successfully applied in synthetic mixture and in pharmaceutical preparations, the results obtained by the proposed techniques were statistically comparable with those obtained by the reported method. All the proposed techniques were validated according to international conference on harmonization (ICH) guidelines.

Development of core-shell magnetic molecularly imprinted polymer-based electrochemical sensor for sensitive and selective detection of ezetimibe

“…Quality control of the drug has become a rigorous tool in pharmacy to ensure product accurate implementation. Analytical techniques that are mainly used for Eze analysis included UV–Vis spectroscopy, liquid chromatography-mass spectrometry (LCMS), ultra performance liquid chromatography (UPLC), densitometry, electrokinetic chromatography, LC/MS-MS, electrophoresis, and voltammetry [ [6] , [7] , [8] , [9] ]. Some of these techniques do not show sufficient detection limits or selectivity in diagnosis, are very time consuming due to complex sample preparation and pre-concentration, and require expensive tools of considerable size [ 10 ].…”